BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

330 related articles for article (PubMed ID: 11224569)

  • 1. Predicting the emergence of antibiotic resistance by directed evolution and structural analysis.
    Orencia MC; Yoon JS; Ness JE; Stemmer WP; Stevens RC
    Nat Struct Biol; 2001 Mar; 8(3):238-42. PubMed ID: 11224569
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Increased folding stability of TEM-1 beta-lactamase by in vitro selection.
    Kather I; Jakob RP; Dobbek H; Schmid FX
    J Mol Biol; 2008 Oct; 383(1):238-51. PubMed ID: 18706424
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The effect of high-frequency random mutagenesis on in vitro protein evolution: a study on TEM-1 beta-lactamase.
    Zaccolo M; Gherardi E
    J Mol Biol; 1999 Jan; 285(2):775-83. PubMed ID: 9878443
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Design and evolution of new catalytic activity with an existing protein scaffold.
    Park HS; Nam SH; Lee JK; Yoon CN; Mannervik B; Benkovic SJ; Kim HS
    Science; 2006 Jan; 311(5760):535-8. PubMed ID: 16439663
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Atomic resolution structures of CTX-M beta-lactamases: extended spectrum activities from increased mobility and decreased stability.
    Chen Y; Delmas J; Sirot J; Shoichet B; Bonnet R
    J Mol Biol; 2005 Apr; 348(2):349-62. PubMed ID: 15811373
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Evolution of an antibiotic resistance enzyme constrained by stability and activity trade-offs.
    Wang X; Minasov G; Shoichet BK
    J Mol Biol; 2002 Jun; 320(1):85-95. PubMed ID: 12079336
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The evolution of cefotaximase activity in the TEM β-lactamase.
    Singh MK; Dominy BN
    J Mol Biol; 2012 Jan; 415(1):205-20. PubMed ID: 22075446
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Structural perturbation and compensation by directed evolution at physiological temperature leads to thermostabilization of beta-lactamase.
    Hecky J; Müller KM
    Biochemistry; 2005 Sep; 44(38):12640-54. PubMed ID: 16171379
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Investigation of the mechanism of resistance to third-generation cephalosporins by class C beta-lactamases by using chemical complementation.
    Carter BT; Lin H; Goldberg SD; Althoff EA; Raushel J; Cornish VW
    Chembiochem; 2005 Nov; 6(11):2055-67. PubMed ID: 16250067
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Darwinian evolution can follow only very few mutational paths to fitter proteins.
    Weinreich DM; Delaney NF; Depristo MA; Hartl DL
    Science; 2006 Apr; 312(5770):111-4. PubMed ID: 16601193
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Amino acid sequence determinants of beta-lactamase structure and activity.
    Huang W; Petrosino J; Hirsch M; Shenkin PS; Palzkill T
    J Mol Biol; 1996 May; 258(4):688-703. PubMed ID: 8637002
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structure-function studies of arginine at position 276 in CTX-M beta-lactamases.
    Pérez-Llarena FJ; Cartelle M; Mallo S; Beceiro A; Pérez A; Villanueva R; Romero A; Bonnet R; Bou G
    J Antimicrob Chemother; 2008 Apr; 61(4):792-7. PubMed ID: 18281307
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Intense neutral drifts yield robust and evolvable consensus proteins.
    Bershtein S; Goldin K; Tawfik DS
    J Mol Biol; 2008 Jun; 379(5):1029-44. PubMed ID: 18495157
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Unexpected enzyme TEM-126: role of mutation Asp179Glu.
    Delmas J; Robin F; Bittar F; Chanal C; Bonnet R
    Antimicrob Agents Chemother; 2005 Oct; 49(10):4280-7. PubMed ID: 16189109
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Probing beta-lactamase structure and function using random replacement mutagenesis.
    Palzkill T; Botstein D
    Proteins; 1992 Sep; 14(1):29-44. PubMed ID: 1329081
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Rapid evolution of a protein in vitro by DNA shuffling.
    Stemmer WP
    Nature; 1994 Aug; 370(6488):389-91. PubMed ID: 8047147
    [TBL] [Abstract][Full Text] [Related]  

  • 17. An engineered disulfide bond between residues 69 and 238 in extended-spectrum beta-lactamase Toho-1 reduces its activity toward third-generation cephalosporins.
    Shimizu-Ibuka A; Matsuzawa H; Sakai H
    Biochemistry; 2004 Dec; 43(50):15737-45. PubMed ID: 15595829
    [TBL] [Abstract][Full Text] [Related]  

  • 18. SHV-129: A Gateway to Global Suppressors in the SHV β-Lactamase Family?
    Winkler ML; Bonomo RA
    Mol Biol Evol; 2016 Feb; 33(2):429-41. PubMed ID: 26531195
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The importance of hinge sequence for loop function and catalytic activity in the reaction catalyzed by triosephosphate isomerase.
    Xiang J; Sun J; Sampson NS
    J Mol Biol; 2001 Apr; 307(4):1103-12. PubMed ID: 11286559
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Stability of TEM beta-lactamase mutants hydrolyzing third generation cephalosporins.
    Raquet X; Vanhove M; Lamotte-Brasseur J; Goussard S; Courvalin P; Frère JM
    Proteins; 1995 Sep; 23(1):63-72. PubMed ID: 8539251
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 17.