140 related articles for article (PubMed ID: 11245918)
1. Effect of PS1 deficiency and an APP gamma-secretase inhibitor on Notch1 signaling in primary mammalian neurons.
Jack C; Berezovska O; Wolfe MS; Hyman BT
Brain Res Mol Brain Res; 2001 Mar; 87(2):166-74. PubMed ID: 11245918
[TBL] [Abstract][Full Text] [Related]
2. Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling.
Berezovska O; Jack C; McLean P; Aster JC; Hicks C; Xia W; Wolfe MS; Kimberly WT; Weinmaster G; Selkoe DJ; Hyman BT
J Neurochem; 2000 Aug; 75(2):583-93. PubMed ID: 10899933
[TBL] [Abstract][Full Text] [Related]
3. Rapid Notch1 nuclear translocation after ligand binding depends on presenilin-associated gamma-secretase activity.
Berezovska O; Jack C; McLean P; Aster JC; Hicks C; Xia W; Wolfe MS; Weinmaster G; Selkoe DJ; Hyman BT
Ann N Y Acad Sci; 2000; 920():223-6. PubMed ID: 11193154
[TBL] [Abstract][Full Text] [Related]
4. Notch1 and amyloid precursor protein are competitive substrates for presenilin1-dependent gamma-secretase cleavage.
Berezovska O; Jack C; Deng A; Gastineau N; Rebeck GW; Hyman BT
J Biol Chem; 2001 Aug; 276(32):30018-23. PubMed ID: 11408475
[TBL] [Abstract][Full Text] [Related]
5. Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression.
Lleó A; Berezovska O; Ramdya P; Fukumoto H; Raju S; Shah T; Hyman BT
J Biol Chem; 2003 Nov; 278(48):47370-5. PubMed ID: 12960155
[TBL] [Abstract][Full Text] [Related]
6. Requirement for presenilin 1 in facilitating lagged 2-mediated endoproteolysis and signaling of notch 1.
Martys-Zage JL; Kim SH; Berechid B; Bingham SJ; Chu S; Sklar J; Nye J; Sisodia SS
J Mol Neurosci; 2000 Dec; 15(3):189-204. PubMed ID: 11303783
[TBL] [Abstract][Full Text] [Related]
7. Cell-free generation of the notch1 intracellular domain (NICD) and APP-CTfgamma: evidence for distinct intramembranous "gamma-secretase" activities.
Ikeuchi T; Sisodia SS
Neuromolecular Med; 2002; 1(1):43-54. PubMed ID: 12025815
[TBL] [Abstract][Full Text] [Related]
8. Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and notch processing.
Soriano S; Kang DE; Fu M; Pestell R; Chevallier N; Zheng H; Koo EH
J Cell Biol; 2001 Feb; 152(4):785-94. PubMed ID: 11266469
[TBL] [Abstract][Full Text] [Related]
9. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.
De Strooper B; Annaert W; Cupers P; Saftig P; Craessaerts K; Mumm JS; Schroeter EH; Schrijvers V; Wolfe MS; Ray WJ; Goate A; Kopan R
Nature; 1999 Apr; 398(6727):518-22. PubMed ID: 10206645
[TBL] [Abstract][Full Text] [Related]
10. Activated Notch1 associates with a presenilin-1/gamma-secretase docking site.
Ramdya P; Skoch J; Bacskai BJ; Hyman BT; Berezovska O
J Neurochem; 2003 Nov; 87(4):843-50. PubMed ID: 14622115
[TBL] [Abstract][Full Text] [Related]
11. Neuronal deficiency of presenilin 1 inhibits amyloid plaque formation and corrects hippocampal long-term potentiation but not a cognitive defect of amyloid precursor protein [V717I] transgenic mice.
Dewachter I; Reversé D; Caluwaerts N; Ris L; Kuipéri C; Van den Haute C; Spittaels K; Umans L; Serneels L; Thiry E; Moechars D; Mercken M; Godaux E; Van Leuven F
J Neurosci; 2002 May; 22(9):3445-53. PubMed ID: 11978821
[TBL] [Abstract][Full Text] [Related]
12. Presenilin-dependent gamma-secretase activity modulates neurite outgrowth.
Figueroa DJ; Morris JA; Ma L; Kandpal G; Chen E; Li YM; Austin CP
Neurobiol Dis; 2002 Feb; 9(1):49-60. PubMed ID: 11848684
[TBL] [Abstract][Full Text] [Related]
13. Presenilin-1 deficiency leads to loss of Cajal-Retzius neurons and cortical dysplasia similar to human type 2 lissencephaly.
Hartmann D; De Strooper B; Saftig P
Curr Biol; 1999 Jul; 9(14):719-27. PubMed ID: 10421573
[TBL] [Abstract][Full Text] [Related]
14. FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex.
Xia W; Ostaszewski BL; Kimberly WT; Rahmati T; Moore CL; Wolfe MS; Selkoe DJ
Neurobiol Dis; 2000 Dec; 7(6 Pt B):673-81. PubMed ID: 11114265
[TBL] [Abstract][Full Text] [Related]
15. Failure of the interaction between presenilin 1 and the substrate of gamma-secretase to produce Abeta in insect cells.
Pitsi D; Kienlen-Campard P; Octave JN
J Neurochem; 2002 Oct; 83(2):390-9. PubMed ID: 12423249
[TBL] [Abstract][Full Text] [Related]
16. Notch oncoproteins depend on gamma-secretase/presenilin activity for processing and function.
Das I; Craig C; Funahashi Y; Jung KM; Kim TW; Byers R; Weng AP; Kutok JL; Aster JC; Kitajewski J
J Biol Chem; 2004 Jul; 279(29):30771-80. PubMed ID: 15123653
[TBL] [Abstract][Full Text] [Related]
17. Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology.
Beher D; Wrigley JD; Nadin A; Evin G; Masters CL; Harrison T; Castro JL; Shearman MS
J Biol Chem; 2001 Nov; 276(48):45394-402. PubMed ID: 11574530
[TBL] [Abstract][Full Text] [Related]
18. Implication of APP secretases in notch signaling.
Hartmann D; Tournoy J; Saftig P; Annaert W; De Strooper B
J Mol Neurosci; 2001 Oct; 17(2):171-81. PubMed ID: 11816790
[TBL] [Abstract][Full Text] [Related]
19. The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein.
Cupers P; Bentahir M; Craessaerts K; Orlans I; Vanderstichele H; Saftig P; De Strooper B; Annaert W
J Cell Biol; 2001 Aug; 154(4):731-40. PubMed ID: 11502763
[TBL] [Abstract][Full Text] [Related]
20. Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons.
Annaert WG; Levesque L; Craessaerts K; Dierinck I; Snellings G; Westaway D; George-Hyslop PS; Cordell B; Fraser P; De Strooper B
J Cell Biol; 1999 Oct; 147(2):277-94. PubMed ID: 10525535
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
