140 related articles for article (PubMed ID: 11249134)
1. Synthesis and biological evaluation of prodrug-type anti-HIV agents: ester conjugates of carboxylic acid-containing dipeptide HIV protease inhibitors and a reverse transcriptase inhibitor.
Matsumoto H; Matsuda T; Nakata S; Mitoguchi T; Kimura T; Hayashi Y; Kiso Y
Bioorg Med Chem; 2001 Feb; 9(2):417-30. PubMed ID: 11249134
[TBL] [Abstract][Full Text] [Related]
2. Design, synthesis, and biological evaluation of anti-HIV double-drugs. conjugates of HIV protease inhibitors with a reverse transcriptase inhibitor through spontaneously cleavable linkers.
Matsumoto H; Kimura T; Hamawaki T; Kumagai A; Goto T; Sano K; Hayashi Y; Kiso Y
Bioorg Med Chem; 2001 Jun; 9(6):1589-600. PubMed ID: 11408178
[TBL] [Abstract][Full Text] [Related]
3. Synthesis of prodrug-type anti-HIV agents conjugating a REVERSE transcriptase inhibitor to a HIV-1 integrase inhibitor by a spontaneously cleavable linker.
Fossey C; Vu AH; Vidu A; Zarafu I; Laduree D; Schmidt S; Laumond G; Aubertin AM
J Enzyme Inhib Med Chem; 2007 Oct; 22(5):591-607. PubMed ID: 18035828
[TBL] [Abstract][Full Text] [Related]
4. Prodrugs of HIV protease inhibitors-saquinavir, indinavir and nelfinavir-derived from diglycerides or amino acids: synthesis, stability and anti-HIV activity.
Gaucher B; Rouquayrol M; Roche D; Greiner J; Aubertin AM; Vierling P
Org Biomol Chem; 2004 Feb; 2(3):345-57. PubMed ID: 14747863
[TBL] [Abstract][Full Text] [Related]
5. A new class of anti-HIV agents: synthesis and activity of conjugates of HIV protease inhibitors with a reverse transcriptase inhibitor.
Kimura T; Matsumoto H; Matsuda T; Hamawaki T; Akaji K; Kiso Y
Bioorg Med Chem Lett; 1999 Mar; 9(6):803-6. PubMed ID: 10206539
[TBL] [Abstract][Full Text] [Related]
6. Synthesis of poly(ethylene glycol)-based saquinavir prodrug conjugates and assessment of release and anti-HIV-1 bioactivity using a novel protease inhibition assay.
Gunaseelan S; Debrah O; Wan L; Leibowitz MJ; Rabson AB; Stein S; Sinko PJ
Bioconjug Chem; 2004; 15(6):1322-33. PubMed ID: 15546199
[TBL] [Abstract][Full Text] [Related]
7. Strategies in the design of prodrugs of anti-HIV agents.
Calogeropoulou T; Detsi A; Lekkas E; Koufaki M
Curr Top Med Chem; 2003; 3(13):1467-95. PubMed ID: 14529522
[TBL] [Abstract][Full Text] [Related]
8. 'Double-Drugs'--a new class of prodrug form of an HIV protease inhibitor conjugated with a reverse transcriptase inhibitor by a spontaneously cleavable linker.
Matsumoto H; Hamawaki T; Ota H; Kimura T; Goto T; Sano K; Hayashi Y; Kiso Y
Bioorg Med Chem Lett; 2000 Jun; 10(11):1227-31. PubMed ID: 10866387
[TBL] [Abstract][Full Text] [Related]
9. Potent HIV-1 Protease Inhibitors Containing Carboxylic and Boronic Acids: Effect on Enzyme Inhibition and Antiviral Activity and Protein-Ligand X-ray Structural Studies.
Ghosh AK; Xia Z; Kovela S; Robinson WL; Johnson ME; Kneller DW; Wang YF; Aoki M; Takamatsu Y; Weber IT; Mitsuya H
ChemMedChem; 2019 Nov; 14(21):1863-1872. PubMed ID: 31549492
[TBL] [Abstract][Full Text] [Related]
10. AZT and AZT-monophosphate prodrugs incorporating HIV-protease substrate fragment: synthesis and evaluation as specific drug delivery systems.
Liotard JF; Mehiri M; Di Giorgio A; Boggetto N; Reboud-Ravaux M; Aubertin AM; Condom R; Patino N
Antivir Chem Chemother; 2006; 17(4):193-213. PubMed ID: 17066898
[TBL] [Abstract][Full Text] [Related]
11. Synthesis, anti-human immunodeficiency virus activity and esterase lability of some novel carboxylic ester-modified phosphoramidate derivatives of stavudine (d4T).
McGuigan C; Sutton PW; Cahard D; Turner K; O'Leary G; Wang Y; Gumbleton M; De Clercq E; Balzarini J
Antivir Chem Chemother; 1998 Nov; 9(6):473-9. PubMed ID: 9865385
[TBL] [Abstract][Full Text] [Related]
12. Synthesis and anti-HIV activities of glutamate and peptide conjugates of nucleoside reverse transcriptase inhibitors.
Agarwal HK; Chhikara BS; Quiterio M; Doncel GF; Parang K
J Med Chem; 2012 Mar; 55(6):2672-87. PubMed ID: 22352809
[TBL] [Abstract][Full Text] [Related]
13. Synthesis and anti-HIV activity of glucose-containing prodrugs derived from saquinavir, indinavir and nelfinavir.
Rouquayrol M; Gaucher B; Greiner J; Aubertin AM; Vierling P; Guedj R
Carbohydr Res; 2001 Nov; 336(3):161-80. PubMed ID: 11705466
[TBL] [Abstract][Full Text] [Related]
14. Tri-N-Boc-tetraazamacrocycle-nucleoside conjugates: synthesis and anti-HIV activities.
Dessolin J; Vlieghe P; Bouygues M; Medou M; Quéléver G; Camplo M; Chermann JC; Kraus JL
Nucleosides Nucleotides; 1998 May; 17(5):957-68. PubMed ID: 9708333
[TBL] [Abstract][Full Text] [Related]
15. Novel pyridinium-type fullerene derivatives as multitargeting inhibitors of HIV-1 reverse transcriptase, HIV-1 protease, and HCV NS5B polymerase.
Kobayashi T; Yasuno T; Takahashi K; Nakamura S; Mashino T; Ohe T
Bioorg Med Chem Lett; 2021 Oct; 49():128267. PubMed ID: 34271071
[TBL] [Abstract][Full Text] [Related]
16. Water-soluble prodrugs of dipeptide HIV protease inhibitors based on O-->N intramolecular acyl migration: Design, synthesis and kinetic study.
Hamada Y; Matsumoto H; Yamaguchi S; Kimura T; Hayashi Y; Kiso Y
Bioorg Med Chem; 2004 Jan; 12(1):159-70. PubMed ID: 14697781
[TBL] [Abstract][Full Text] [Related]
17. Design, synthesis, and anti-HIV activity of 4'-modified carbocyclic nucleoside phosphonate reverse transcriptase inhibitors.
Boojamra CG; Parrish JP; Sperandio D; Gao Y; Petrakovsky OV; Lee SK; Markevitch DY; Vela JE; Laflamme G; Chen JM; Ray AS; Barron AC; Sparacino ML; Desai MC; Kim CU; Cihlar T; Mackman RL
Bioorg Med Chem; 2009 Feb; 17(4):1739-46. PubMed ID: 19179082
[TBL] [Abstract][Full Text] [Related]
18. Synthesis, anti-HIV activity, and metabolic stability of new alkenyldiarylmethane HIV-1 non-nucleoside reverse transcriptase inhibitors.
Deng BL; Hartman TL; Buckheit RW; Pannecouque C; De Clercq E; Fanwick PE; Cushman M
J Med Chem; 2005 Sep; 48(19):6140-55. PubMed ID: 16162014
[TBL] [Abstract][Full Text] [Related]
19. Design and discovery of a novel dipeptidyl-peptidase IV (CD26)-based prodrug approach.
García-Aparicio C; Bonache MC; De Meester I; San-Félix A; Balzarini J; Camarasa MJ; Velazquez S
J Med Chem; 2006 Aug; 49(17):5339-51. PubMed ID: 16913724
[TBL] [Abstract][Full Text] [Related]
20. Discovery of GS-9131: Design, synthesis and optimization of amidate prodrugs of the novel nucleoside phosphonate HIV reverse transcriptase (RT) inhibitor GS-9148.
Mackman RL; Ray AS; Hui HC; Zhang L; Birkus G; Boojamra CG; Desai MC; Douglas JL; Gao Y; Grant D; Laflamme G; Lin KY; Markevitch DY; Mishra R; McDermott M; Pakdaman R; Petrakovsky OV; Vela JE; Cihlar T
Bioorg Med Chem; 2010 May; 18(10):3606-17. PubMed ID: 20409721
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]