146 related articles for article (PubMed ID: 11297454)
1. Flexible estrogen receptor modulators: design, synthesis, and antagonistic effects in human MCF-7 breast cancer cells.
Meegan MJ; Hughes RB; Lloyd DG; Williams DC; Zisterer DM
J Med Chem; 2001 Mar; 44(7):1072-84. PubMed ID: 11297454
[TBL] [Abstract][Full Text] [Related]
2. Ethyl side-chain modifications in novel flexible antiestrogens--design, synthesis and biological efficacy in assay against the MCF-7 breast tumor cell line.
Meegan MJ; Hughes RB; Lloyd DG; Williams DC; Zisterer DM
Anticancer Drug Des; 2001 Feb; 16(1):57-69. PubMed ID: 11762645
[TBL] [Abstract][Full Text] [Related]
3. Antiestrogenically active 2-benzyl-1,1-diarylbut-2-enes: synthesis, structure-activity relationships and molecular modeling study for flexible estrogen receptor antagonists.
Lloyd DG; Smith HM; O'Sullivan T; Knox AS; Zisterer DM; Meegan MJ
Med Chem; 2006 Mar; 2(2):147-68. PubMed ID: 16787364
[TBL] [Abstract][Full Text] [Related]
4. Synthesis, structure-activity relationships and antagonistic effects in human MCF-7 breast cancer cells of flexible estrogen receptor modulators.
Lloyd DG; Smith HM; O'Sullivan T; Zisterer DM; Meegan MJ
Med Chem; 2005 Jul; 1(4):335-53. PubMed ID: 16789891
[TBL] [Abstract][Full Text] [Related]
5. Carboxylic acid analogues of tamoxifen: (Z)-2-[p-(1, 2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine. Estrogen receptor affinity and estrogen antagonist effects in MCF-7 cells.
Kraft KS; Ruenitz PC; Bartlett MG
J Med Chem; 1999 Aug; 42(16):3126-33. PubMed ID: 10447957
[TBL] [Abstract][Full Text] [Related]
6. Flexible estrogen receptor modulators: synthesis, biochemistry and molecular modeling studies for 3-benzyl-4,6-diarylhex-3-ene and 3,4,6-triarylhex-3-ene derivatives.
Smith HM; Knox AJ; Zisterer DM; Lloyd DG; Meegan MJ
Med Chem; 2007 Mar; 3(2):135-55. PubMed ID: 17348852
[TBL] [Abstract][Full Text] [Related]
7. Synthesis and pharmacology of conformationally restricted raloxifene analogues: highly potent selective estrogen receptor modulators.
Grese TA; Pennington LD; Sluka JP; Adrian MD; Cole HW; Fuson TR; Magee DE; Phillips DL; Rowley ER; Shetler PK; Short LL; Venugopalan M; Yang NN; Sato M; Glasebrook AL; Bryant HU
J Med Chem; 1998 Apr; 41(8):1272-83. PubMed ID: 9548817
[TBL] [Abstract][Full Text] [Related]
8. Structure-based design and synthesis of conformationally constrained derivatives of methyl-piperidinopyrazole (MPP) with estrogen receptor (ER) antagonist activity.
Ragab MA; Elagawany M; Daabees H; Ahmed AF; Awad EM; Billon C; Elgendy B; Abouzid KAM; Kassab SE
Bioorg Chem; 2022 Feb; 119():105554. PubMed ID: 34923243
[TBL] [Abstract][Full Text] [Related]
9. Structure-activity relationships of nonisomerizable derivatives of tamoxifen: importance of hydroxyl group and side chain positioning for biological activity.
Murphy CS; Parker CJ; McCague R; Jordan VC
Mol Pharmacol; 1991 Mar; 39(3):421-8. PubMed ID: 2005879
[TBL] [Abstract][Full Text] [Related]
10. Benzothiepin-derived molecular scaffolds for estrogen receptor modulators: synthesis and antagonistic effects in breast cancer cells.
Meegan MJ; Barrett I; Zimmermann J; Knox AJ; Zisterer DM; Lloyd DG
J Enzyme Inhib Med Chem; 2007 Oct; 22(5):655-66. PubMed ID: 18035834
[TBL] [Abstract][Full Text] [Related]
11. Investigations on estrogen receptor binding. The estrogenic, antiestrogenic, and cytotoxic properties of C2-alkyl-substituted 1,1-bis(4-hydroxyphenyl)-2-phenylethenes.
Lubczyk V; Bachmann H; Gust R
J Med Chem; 2002 Nov; 45(24):5358-64. PubMed ID: 12431063
[TBL] [Abstract][Full Text] [Related]
12. Antiestrogens. 3. Estrogen receptor affinities and antiproliferative effects in MCF-7 cells of phenolic analogues of trioxifene, [3,4-dihydro-2-(4- methoxyphenyl)-1-naphthalenyl][4-[2-(1-pyrrolidinyl)ethoxy]- phenyl]methanone.
Jones CD; Blaszczak LC; Goettel ME; Suarez T; Crowell TA; Mabry TE; Ruenitz PC; Srivatsan V
J Med Chem; 1992 Mar; 35(5):931-8. PubMed ID: 1548683
[TBL] [Abstract][Full Text] [Related]
13. A new antiestrogen, 2-(4-hydroxy-phenyl)-3-methyl-1-[4-(2-piperidin-1-yl-ethoxy)-benzyl]-1H-indol-5-ol hydrochloride (ERA-923), inhibits the growth of tamoxifen-sensitive and -resistant tumors and is devoid of uterotropic effects in mice and rats.
Greenberger LM; Annable T; Collins KI; Komm BS; Lyttle CR; Miller CP; Satyaswaroop PG; Zhang Y; Frost P
Clin Cancer Res; 2001 Oct; 7(10):3166-77. PubMed ID: 11595711
[TBL] [Abstract][Full Text] [Related]
14. Photochemical synthesis of N-arylbenzophenanthridine selective estrogen receptor modulators (serms).
Grese TA; Adrian MD; Phillips DL; Shetler PK; Short LL; Glasebrook AL; Bryant HU
J Med Chem; 2001 Aug; 44(17):2857-60. PubMed ID: 11495597
[TBL] [Abstract][Full Text] [Related]
15. Synthesis and evaluation of novel N-substituted N'-(3-hydroxy-17-oxoestra-1,3,5(10)-trien-2- and -4-yl)thiourea derivatives for binding to the estrogen receptor and cytotoxic activity on MCF-7 cells.
Omar AM; Aboulwafa OM; Leclercq G
J Pharm Sci; 1984 Dec; 73(12):1871-3. PubMed ID: 6441843
[TBL] [Abstract][Full Text] [Related]
16. Discovery and synthesis of [6-hydroxy-3-[4-[2-(1-piperidinyl)ethoxy]phenoxy]-2-(4-hydroxyphenyl)]b enzo[b]thiophene: a novel, highly potent, selective estrogen receptor modulator.
Palkowitz AD; Glasebrook AL; Thrasher KJ; Hauser KL; Short LL; Phillips DL; Muehl BS; Sato M; Shetler PK; Cullinan GJ; Pell TR; Bryant HU
J Med Chem; 1997 May; 40(10):1407-16. PubMed ID: 9154963
[TBL] [Abstract][Full Text] [Related]
17. 3,3'4,4'-Tetrachlorobiphenyl exhibits antiestrogenic and antitumorigenic activity in the rodent uterus and mammary cells and in human breast cancer cells.
Ramamoorthy K; Gupta MS; Sun G; McDougal A; Safe SH
Carcinogenesis; 1999 Jan; 20(1):115-23. PubMed ID: 9934858
[TBL] [Abstract][Full Text] [Related]
18. Molecular determinants of tissue selectivity in estrogen receptor modulators.
Grese TA; Sluka JP; Bryant HU; Cullinan GJ; Glasebrook AL; Jones CD; Matsumoto K; Palkowitz AD; Sato M; Termine JD; Winter MA; Yang NN; Dodge JA
Proc Natl Acad Sci U S A; 1997 Dec; 94(25):14105-10. PubMed ID: 9391160
[TBL] [Abstract][Full Text] [Related]
19. The Structure-Function Relationship of Angular Estrogens and Estrogen Receptor Alpha to Initiate Estrogen-Induced Apoptosis in Breast Cancer Cells.
Maximov PY; Abderrahman B; Hawsawi YM; Chen Y; Foulds CE; Jain A; Malovannaya A; Fan P; Curpan RF; Han R; Fanning SW; Broom BM; Quintana Rincon DM; Greenland JA; Greene GL; Jordan VC
Mol Pharmacol; 2020 Jul; 98(1):24-37. PubMed ID: 32362585
[TBL] [Abstract][Full Text] [Related]
20. Bioactivities, estrogen receptor interactions, and plasminogen activator-inducing activities of tamoxifen and hydroxy-tamoxifen isomers in MCF-7 human breast cancer cells.
Katzenellenbogen BS; Norman MJ; Eckert RL; Peltz SW; Mangel WF
Cancer Res; 1984 Jan; 44(1):112-9. PubMed ID: 6537799
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
