These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

284 related articles for article (PubMed ID: 11305921)

  • 1. Biochemical characterization of the gamma-secretase activity that produces beta-amyloid peptides.
    Zhang L; Song L; Terracina G; Liu Y; Pramanik B; Parker E
    Biochemistry; 2001 Apr; 40(16):5049-55. PubMed ID: 11305921
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Calpain inhibitor I increases beta-amyloid peptide production by inhibiting the degradation of the substrate of gamma-secretase. Evidence that substrate availability limits beta-amyloid peptide production.
    Zhang L; Song L; Parker EM
    J Biol Chem; 1999 Mar; 274(13):8966-72. PubMed ID: 10085142
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Purification and characterization of the human gamma-secretase complex.
    Fraering PC; Ye W; Strub JM; Dolios G; LaVoie MJ; Ostaszewski BL; van Dorsselaer A; Wang R; Selkoe DJ; Wolfe MS
    Biochemistry; 2004 Aug; 43(30):9774-89. PubMed ID: 15274632
    [TBL] [Abstract][Full Text] [Related]  

  • 4. APH1, PEN2, and Nicastrin increase Abeta levels and gamma-secretase activity.
    Marlow L; Canet RM; Haugabook SJ; Hardy JA; Lahiri DK; Sambamurti K
    Biochem Biophys Res Commun; 2003 Jun; 305(3):502-9. PubMed ID: 12763021
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Generation of C-terminally truncated amyloid-beta peptides is dependent on gamma-secretase activity.
    Beher D; Wrigley JD; Owens AP; Shearman MS
    J Neurochem; 2002 Aug; 82(3):563-75. PubMed ID: 12153480
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Effect of protein kinase A inhibitors on the production of Abeta40 and Abeta42 by human cells expressing normal and Alzheimer's disease-linked mutated betaAPP and presenilin 1.
    Marambaud P; Ancolio K; Alves da Costa C; Checler F
    Br J Pharmacol; 1999 Mar; 126(5):1186-90. PubMed ID: 10205007
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Auraptene increases the production of amyloid-β via c-Jun N-terminal kinase-dependent activation of γ-secretase.
    Jung CG; Uhm KO; Horike H; Kim MJ; Misumi S; Ishida A; Ueda Y; Choi EK; Kim YS; Michikawa M; Hida H
    J Alzheimers Dis; 2015; 43(4):1215-28. PubMed ID: 25147119
    [TBL] [Abstract][Full Text] [Related]  

  • 8. A novel gamma -secretase assay based on detection of the putative C-terminal fragment-gamma of amyloid beta protein precursor.
    Pinnix I; Musunuru U; Tun H; Sridharan A; Golde T; Eckman C; Ziani-Cherif C; Onstead L; Sambamurti K
    J Biol Chem; 2001 Jan; 276(1):481-7. PubMed ID: 11035007
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Rank-order of potencies for inhibition of the secretion of abeta40 and abeta42 suggests that both are generated by a single gamma-secretase.
    Durkin JT; Murthy S; Husten EJ; Trusko SP; Savage MJ; Rotella DP; Greenberg BD; Siman R
    J Biol Chem; 1999 Jul; 274(29):20499-504. PubMed ID: 10400678
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Characterization of the reconstituted gamma-secretase complex from Sf9 cells co-expressing presenilin 1, nicastrin [correction of nacastrin], aph-1a, and pen-2.
    Zhang L; Lee J; Song L; Sun X; Shen J; Terracina G; Parker EM
    Biochemistry; 2005 Mar; 44(11):4450-7. PubMed ID: 15766275
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Intracellular site of gamma-secretase cleavage for Abeta42 generation in neuro 2a cells harbouring a presenilin 1 mutation.
    Sudoh S; Hua G; Kawamura Y; Maruyama K; Komano H; Yanagisawa K
    Eur J Biochem; 2000 Apr; 267(7):2036-45. PubMed ID: 10727943
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Modulation of γ-secretase activity by multiple enzyme-substrate interactions: implications in pathogenesis of Alzheimer's disease.
    Svedružić ZM; Popović K; Smoljan I; Sendula-Jengić V
    PLoS One; 2012; 7(3):e32293. PubMed ID: 22479317
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Amyloid precursor protein compartmentalization restricts beta-amyloid production: therapeutic targets based on BACE compartmentalization.
    Gandhi S; Refolo LM; Sambamurti K
    J Mol Neurosci; 2004; 24(1):137-43. PubMed ID: 15314262
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.
    Wolfe MS; Xia W; Ostaszewski BL; Diehl TS; Kimberly WT; Selkoe DJ
    Nature; 1999 Apr; 398(6727):513-7. PubMed ID: 10206644
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Familial Alzheimer disease-linked presenilin 1 variants enhance production of both Abeta 1-40 and Abeta 1-42 peptides that are only partially sensitive to a potent aspartyl protease transition state inhibitor of "gamma-secretase".
    Ikeuchi T; Dolios G; Kim SH; Wang R; Sisodia SS
    J Biol Chem; 2003 Feb; 278(9):7010-8. PubMed ID: 12493731
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Presenilin endoproteolysis mediated by an aspartyl protease activity pharmacologically distinct from gamma-secretase.
    Campbell WA; Reed ML; Strahle J; Wolfe MS; Xia W
    J Neurochem; 2003 Jun; 85(6):1563-74. PubMed ID: 12787075
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase.
    Jankowsky JL; Fadale DJ; Anderson J; Xu GM; Gonzales V; Jenkins NA; Copeland NG; Lee MK; Younkin LH; Wagner SL; Younkin SG; Borchelt DR
    Hum Mol Genet; 2004 Jan; 13(2):159-70. PubMed ID: 14645205
    [TBL] [Abstract][Full Text] [Related]  

  • 18. New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage.
    Petit A; Bihel F; Alvès da Costa C; Pourquié O; Checler F; Kraus JL
    Nat Cell Biol; 2001 May; 3(5):507-11. PubMed ID: 11331880
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state.
    Li YM; Lai MT; Xu M; Huang Q; DiMuzio-Mower J; Sardana MK; Shi XP; Yin KC; Shafer JA; Gardell SJ
    Proc Natl Acad Sci U S A; 2000 May; 97(11):6138-43. PubMed ID: 10801983
    [TBL] [Abstract][Full Text] [Related]  

  • 20. {gamma}-Secretase Substrate Concentration Modulates the Abeta42/Abeta40 Ratio: IMPLICATIONS FOR ALZHEIMER DISEASE.
    Yin YI; Bassit B; Zhu L; Yang X; Wang C; Li YM
    J Biol Chem; 2007 Aug; 282(32):23639-44. PubMed ID: 17556361
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.