163 related articles for article (PubMed ID: 11311068)
1. Antitumor benzothiazoles. 14. Synthesis and in vitro biological properties of fluorinated 2-(4-aminophenyl)benzothiazoles.
Hutchinson I; Chua MS; Browne HL; Trapani V; Bradshaw TD; Westwell AD; Stevens MF
J Med Chem; 2001 Apr; 44(9):1446-55. PubMed ID: 11311068
[TBL] [Abstract][Full Text] [Related]
2. Antitumor benzothiazoles. 8. Synthesis, metabolic formation, and biological properties of the C- and N-oxidation products of antitumor 2-(4-aminophenyl)benzothiazoles.
Kashiyama E; Hutchinson I; Chua MS; Stinson SF; Phillips LR; Kaur G; Sausville EA; Bradshaw TD; Westwell AD; Stevens MF
J Med Chem; 1999 Oct; 42(20):4172-84. PubMed ID: 10514287
[TBL] [Abstract][Full Text] [Related]
3. Fluorinated 2-(4-amino-3-methylphenyl)benzothiazoles induce CYP1A1 expression, become metabolized, and bind to macromolecules in sensitive human cancer cells.
Brantley E; Trapani V; Alley MC; Hose CD; Bradshaw TD; Stevens MF; Sausville EA; Stinson SF
Drug Metab Dispos; 2004 Dec; 32(12):1392-401. PubMed ID: 15355884
[TBL] [Abstract][Full Text] [Related]
4. Role of Cyp1A1 in modulation of antitumor properties of the novel agent 2-(4-amino-3-methylphenyl)benzothiazole (DF 203, NSC 674495) in human breast cancer cells.
Chua MS; Kashiyama E; Bradshaw TD; Stinson SF; Brantley E; Sausville EA; Stevens MF
Cancer Res; 2000 Sep; 60(18):5196-203. PubMed ID: 11016648
[TBL] [Abstract][Full Text] [Related]
5. Antitumour benzothiazoles. Part 20: 3'-cyano and 3'-alkynyl-substituted 2-(4'-aminophenyl)benzothiazoles as new potent and selective analogues.
Hutchinson I; Bradshaw TD; Matthews CS; Stevens MF; Westwell AD
Bioorg Med Chem Lett; 2003 Feb; 13(3):471-4. PubMed ID: 12565953
[TBL] [Abstract][Full Text] [Related]
6. Antitumor benzothiazoles. 26.(1) 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (GW 610, NSC 721648), a simple fluorinated 2-arylbenzothiazole, shows potent and selective inhibitory activity against lung, colon, and breast cancer cell lines.
Mortimer CG; Wells G; Crochard JP; Stone EL; Bradshaw TD; Stevens MF; Westwell AD
J Med Chem; 2006 Jan; 49(1):179-85. PubMed ID: 16392802
[TBL] [Abstract][Full Text] [Related]
7. 2-(4-Aminophenyl)benzothiazoles: novel agents with selective profiles of in vitro anti-tumour activity.
Bradshaw TD; Wrigley S; Shi DF; Schultz RJ; Paull KD; Stevens MF
Br J Cancer; 1998 Mar; 77(5):745-52. PubMed ID: 9514053
[TBL] [Abstract][Full Text] [Related]
8. 2-(4-aminophenyl) benzothiazole: a potent and selective pharmacophore with novel mechanistic action towards various tumour cell lines.
Dubey R; Shrivastava PK; Basniwal PK; Bhattacharya S; Moorthy NS
Mini Rev Med Chem; 2006 Jun; 6(6):633-7. PubMed ID: 16787373
[TBL] [Abstract][Full Text] [Related]
9. Antitumor benzothiazoles. 3. Synthesis of 2-(4-aminophenyl)benzothiazoles and evaluation of their activities against breast cancer cell lines in vitro and in vivo.
Shi DF; Bradshaw TD; Wrigley S; McCall CJ; Lelieveld P; Fichtner I; Stevens MF
J Med Chem; 1996 Aug; 39(17):3375-84. PubMed ID: 8765521
[TBL] [Abstract][Full Text] [Related]
10. Preclinical evaluation of amino acid prodrugs of novel antitumor 2-(4-amino-3-methylphenyl)benzothiazoles.
Bradshaw TD; Bibby MC; Double JA; Fichtner I; Cooper PA; Alley MC; Donohue S; Stinson SF; Tomaszewjski JE; Sausville EA; Stevens MF
Mol Cancer Ther; 2002 Feb; 1(4):239-46. PubMed ID: 12467219
[TBL] [Abstract][Full Text] [Related]
11. The discovery of the potent and selective antitumour agent 2-(4-amino-3-methylphenyl)benzothiazole (DF 203) and related compounds.
Bradshaw TD; Stevens MF; Westwell AD
Curr Med Chem; 2001 Feb; 8(2):203-10. PubMed ID: 11172675
[TBL] [Abstract][Full Text] [Related]
12. Bioactivation of fluorinated 2-aryl-benzothiazole antitumor molecules by human cytochrome P450s 1A1 and 2W1 and deactivation by cytochrome P450 2S1.
Wang K; Guengerich FP
Chem Res Toxicol; 2012 Aug; 25(8):1740-51. PubMed ID: 22734839
[TBL] [Abstract][Full Text] [Related]
13. Aryl hydrocarbon receptor mediates sensitivity of MCF-7 breast cancer cells to antitumor agent 2-(4-amino-3-methylphenyl) benzothiazole.
Loaiza-Pérez AI; Trapani V; Hose C; Singh SS; Trepel JB; Stevens MF; Bradshaw TD; Sausville EA
Mol Pharmacol; 2002 Jan; 61(1):13-9. PubMed ID: 11752201
[TBL] [Abstract][Full Text] [Related]
14. Mechanisms of acquired resistance to 2-(4-aminophenyl)benzothiazole (CJM 126, NSC 34445).
Bradshaw TD; Chua MS; Orr S; Matthews CS; Stevens MF
Br J Cancer; 2000 Jul; 83(2):270-7. PubMed ID: 10901382
[TBL] [Abstract][Full Text] [Related]
15. Structural studies on bioactive compounds. 40.(1) Synthesis and biological properties of fluoro-, methoxyl-, and amino-substituted 3-phenyl-4H-1-benzopyran-4-ones and a comparison of their antitumor activities with the activities of related 2-phenylbenzothiazoles.
Vasselin DA; Westwell AD; Matthews CS; Bradshaw TD; Stevens MF
J Med Chem; 2006 Jun; 49(13):3973-81. PubMed ID: 16789754
[TBL] [Abstract][Full Text] [Related]
16. 4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
Wells G; Berry JM; Bradshaw TD; Burger AM; Seaton A; Wang B; Westwell AD; Stevens MF
J Med Chem; 2003 Feb; 46(4):532-41. PubMed ID: 12570375
[TBL] [Abstract][Full Text] [Related]
17. CYP2S1 and CYP2W1 mediate 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (GW-610, NSC 721648) sensitivity in breast and colorectal cancer cells.
Tan BS; Tiong KH; Muruhadas A; Randhawa N; Choo HL; Bradshaw TD; Stevens MF; Leong CO
Mol Cancer Ther; 2011 Oct; 10(10):1982-92. PubMed ID: 21831963
[TBL] [Abstract][Full Text] [Related]
18. The development of the antitumour benzothiazole prodrug, Phortress, as a clinical candidate.
Bradshaw TD; Westwell AD
Curr Med Chem; 2004 Apr; 11(8):1009-21. PubMed ID: 15078163
[TBL] [Abstract][Full Text] [Related]
19. Antitumour 2-(4-aminophenyl)benzothiazoles generate DNA adducts in sensitive tumour cells in vitro and in vivo.
Leong CO; Gaskell M; Martin EA; Heydon RT; Farmer PB; Bibby MC; Cooper PA; Double JA; Bradshaw TD; Stevens MF
Br J Cancer; 2003 Feb; 88(3):470-7. PubMed ID: 12569393
[TBL] [Abstract][Full Text] [Related]
20. Antitumor benzothiazoles. 16. Synthesis and pharmaceutical properties of antitumor 2-(4-aminophenyl)benzothiazole amino acid prodrugs.
Hutchinson I; Jennings SA; Vishnuvajjala BR; Westwell AD; Stevens MF
J Med Chem; 2002 Jan; 45(3):744-7. PubMed ID: 11806726
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
