BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

152 related articles for article (PubMed ID: 11331880)

  • 1. New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage.
    Petit A; Bihel F; Alvès da Costa C; Pourquié O; Checler F; Kraus JL
    Nat Cell Biol; 2001 May; 3(5):507-11. PubMed ID: 11331880
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Gamma-secretase-like cleavages of Notch and beta APP are mutually exclusive in human cells.
    Petit A; St George-Hyslop P; Fraser P; Checler F
    Biochem Biophys Res Commun; 2002 Feb; 290(5):1408-10. PubMed ID: 11820778
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.
    Bentahir M; Nyabi O; Verhamme J; Tolia A; Horré K; Wiltfang J; Esselmann H; De Strooper B
    J Neurochem; 2006 Feb; 96(3):732-42. PubMed ID: 16405513
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Endoproteolysis of the ER stress transducer ATF6 in the presence of functionally inactive presenilins.
    Steiner H; Winkler E; Shearman MS; Prywes R; Haass C
    Neurobiol Dis; 2001 Aug; 8(4):717-22. PubMed ID: 11493036
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Nicastrin binds to membrane-tethered Notch.
    Chen F; Yu G; Arawaka S; Nishimura M; Kawarai T; Yu H; Tandon A; Supala A; Song YQ; Rogaeva E; Milman P; Sato C; Yu C; Janus C; Lee J; Song L; Zhang L; Fraser PE; St George-Hyslop PH
    Nat Cell Biol; 2001 Aug; 3(8):751-4. PubMed ID: 11483961
    [TBL] [Abstract][Full Text] [Related]  

  • 6. APPepsilon, the epsilon-secretase-derived N-terminal product of the beta-amyloid precursor protein, behaves as a type I protein and undergoes alpha-, beta-, and gamma-secretase cleavages.
    Lefranc-Jullien S; Sunyach C; Checler F
    J Neurochem; 2006 May; 97(3):807-17. PubMed ID: 16524370
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Proprotein convertase activity contributes to the processing of the Alzheimer's beta-amyloid precursor protein in human cells: evidence for a role of the prohormone convertase PC7 in the constitutive alpha-secretase pathway.
    Lopez-Perez E; Seidah NG; Checler F
    J Neurochem; 1999 Nov; 73(5):2056-62. PubMed ID: 10537065
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.
    Esler WP; Kimberly WT; Ostaszewski BL; Diehl TS; Moore CL; Tsai JY; Rahmati T; Xia W; Selkoe DJ; Wolfe MS
    Nat Cell Biol; 2000 Jul; 2(7):428-34. PubMed ID: 10878808
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Catalytic site-directed gamma-secretase complex inhibitors do not discriminate pharmacologically between Notch S3 and beta-APP cleavages.
    Lewis HD; Pérez Revuelta BI; Nadin A; Neduvelil JG; Harrison T; Pollack SJ; Shearman MS
    Biochemistry; 2003 Jun; 42(24):7580-6. PubMed ID: 12809514
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Conserved "PAL" sequence in presenilins is essential for gamma-secretase activity, but not required for formation or stabilization of gamma-secretase complexes.
    Wang J; Brunkan AL; Hecimovic S; Walker E; Goate A
    Neurobiol Dis; 2004 Apr; 15(3):654-66. PubMed ID: 15056474
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Presenilin-directed inhibitors of gamma-secretase trigger caspase 3 activation in presenilin-expressing and presenilin-deficient cells.
    Alves da Costa C; Ayral E; Hernandez JF; St George-Hyslop P; Checler F
    J Neurochem; 2004 Aug; 90(4):800-6. PubMed ID: 15287885
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Endogenous beta-amyloid production in presenilin-deficient embryonic mouse fibroblasts.
    Armogida M; Petit A; Vincent B; Scarzello S; da Costa CA; Checler F
    Nat Cell Biol; 2001 Nov; 3(11):1030-3. PubMed ID: 11715026
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Generation of amyloid beta protein from a presenilin-1 and betaAPP complex.
    Shizuka-Ikeda M; Matsubara E; Ikeda M; Kanai M; Tomidokoro Y; Ikeda Y; Watanabe M; Kawarabayashi T; Harigaya Y; Okamoto K; Maruyama K; Castaño EM; St George-Hyslop P; Shoji M
    Biochem Biophys Res Commun; 2002 Mar; 292(2):571-8. PubMed ID: 11906199
    [TBL] [Abstract][Full Text] [Related]  

  • 14. A presenilin-independent aspartyl protease prefers the gamma-42 site cleavage.
    Lai MT; Crouthamel MC; DiMuzio J; Pietrak BL; Donoviel DB; Bernstein A; Gardell SJ; Li YM; Hazuda D
    J Neurochem; 2006 Jan; 96(1):118-25. PubMed ID: 16300640
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Phosphorylation of amyloid precursor carboxy-terminal fragments enhances their processing by a gamma-secretase-dependent mechanism.
    Vingtdeux V; Hamdane M; Gompel M; Bégard S; Drobecq H; Ghestem A; Grosjean ME; Kostanjevecki V; Grognet P; Vanmechelen E; Buée L; Delacourte A; Sergeant N
    Neurobiol Dis; 2005 Nov; 20(2):625-37. PubMed ID: 15936948
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Distinct mechanisms by mutant presenilin 1 and 2 leading to increased intracellular levels of amyloid beta-protein 42 in Chinese hamster ovary cells.
    Qi Y; Morishima-Kawashima M; Sato T; Mitsumori R; Ihara Y
    Biochemistry; 2003 Feb; 42(4):1042-52. PubMed ID: 12549925
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane.
    Kaether C; Lammich S; Edbauer D; Ertl M; Rietdorf J; Capell A; Steiner H; Haass C
    J Cell Biol; 2002 Aug; 158(3):551-61. PubMed ID: 12147673
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Apolipoprotein E modulates gamma-secretase cleavage of the amyloid precursor protein.
    Irizarry MC; Deng A; Lleo A; Berezovska O; Von Arnim CA; Martin-Rehrmann M; Manelli A; LaDu MJ; Hyman BT; Rebeck GW
    J Neurochem; 2004 Sep; 90(5):1132-43. PubMed ID: 15312168
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1.
    Zhang Z; Nadeau P; Song W; Donoviel D; Yuan M; Bernstein A; Yankner BA
    Nat Cell Biol; 2000 Jul; 2(7):463-5. PubMed ID: 10878814
    [No Abstract]   [Full Text] [Related]  

  • 20. Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s).
    Kimberly WT; Esler WP; Ye W; Ostaszewski BL; Gao J; Diehl T; Selkoe DJ; Wolfe MS
    Biochemistry; 2003 Jan; 42(1):137-44. PubMed ID: 12515548
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.