137 related articles for article (PubMed ID: 11334562)
1. Design, synthesis, SAR, and biological evaluation of highly potent benzimidazole-spaced phosphono-alpha-amino acid competitive NMDA antagonists of the AP-6 type.
Baudy RB; Fletcher H; Yardley JP; Zaleska MM; Bramlett DR; Tasse RP; Kowal DM; Katz AH; Moyer JA; Abou-Gharbia M
J Med Chem; 2001 May; 44(10):1516-29. PubMed ID: 11334562
[TBL] [Abstract][Full Text] [Related]
2. Potent quinoxaline-spaced phosphono alpha-amino acids of the AP-6 type as competitive NMDA antagonists: synthesis and biological evaluation.
Baudy RB; Greenblatt LP; Jirkovsky IL; Conklin M; Russo RJ; Bramlett DR; Emrey TA; Simmonds JT; Kowal DM; Stein RP
J Med Chem; 1993 Feb; 36(3):331-42. PubMed ID: 8093907
[TBL] [Abstract][Full Text] [Related]
3. Characterization of two novel N-methyl-D-aspartate antagonists: EAA-090 (2-[8,9-dioxo-2,6-diazabicyclo [5.2.0]non-1(7)-en2-yl]ethylphosphonic acid) and EAB-318 (R-alpha-amino-5-chloro-1-(phosphonomethyl)-1H-benzimidazole-2-propanoic acid hydrochloride).
Sun L; Chiu D; Kowal D; Simon R; Smeyne M; Zukin RS; Olney J; Baudy R; Lin S
J Pharmacol Exp Ther; 2004 Aug; 310(2):563-70. PubMed ID: 15075380
[TBL] [Abstract][Full Text] [Related]
4. Chiral synthesis and pharmacological evaluation of NPS 1407: a potent, stereoselective NMDA receptor antagonist.
Moe ST; Smith DL; DelMar EG; Shimizu SM; Van Wagenen BC; Balandrin MF; Chien YE; Raszkiewicz JL; Artman LD; White HS; Mueller AL
Bioorg Med Chem Lett; 2000 Nov; 10(21):2411-5. PubMed ID: 11078190
[TBL] [Abstract][Full Text] [Related]
5. Synthesis and pharmacological evaluation of N-(2,5-disubstituted phenyl)-N'-(3-substituted phenyl)-N'-methylguanidines as N-methyl-D-aspartate receptor ion-channel blockers.
Hu LY; Guo J; Magar SS; Fischer JB; Burke-Howie KJ; Durant GJ
J Med Chem; 1997 Dec; 40(26):4281-9. PubMed ID: 9435897
[TBL] [Abstract][Full Text] [Related]
6. Design and synthesis of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)-ethyl]phosphonic acid (EAA-090), a potent N-methyl-D-aspartate antagonist, via the use of 3-cyclobutene-1,2-dione as an achiral alpha-amino acid bioisostere.
Kinney WA; Abou-Gharbia M; Garrison DT; Schmid J; Kowal DM; Bramlett DR; Miller TL; Tasse RP; Zaleska MM; Moyer JA
J Med Chem; 1998 Jan; 41(2):236-46. PubMed ID: 9457246
[TBL] [Abstract][Full Text] [Related]
7. Novel class of amino acid antagonists at non-N-methyl-D-aspartic acid excitatory amino acid receptors. Synthesis, in vitro and in vivo pharmacology, and neuroprotection.
Krogsgaard-Larsen P; Ferkany JW; Nielsen EO; Madsen U; Ebert B; Johansen JS; Diemer NH; Bruhn T; Beattie DT; Curtis DR
J Med Chem; 1991 Jan; 34(1):123-30. PubMed ID: 1825114
[TBL] [Abstract][Full Text] [Related]
8. Biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitive N-methyl-D-aspartate receptor antagonists--II. Pharmacological characterization in vivo.
Urwyler S; Campbell E; Fricker G; Jenner P; Lemaire M; McAllister KH; Neijt HC; Park CK; Perkins M; Rudin M; Sauter A; Smith L; Wiederhold KH; Müller W
Neuropharmacology; 1996 Jun; 35(6):655-69. PubMed ID: 8887975
[TBL] [Abstract][Full Text] [Related]
9. Potent, orally active, competitive N-methyl-D-aspartate (NMDA) receptor antagonists are substrates for a neutral amino acid uptake system in Chinese hamster ovary cells.
Li JH; Bigge CF; Williamson RM; Borosky SA; Vartanian MG; Ortwine DF
J Med Chem; 1995 May; 38(11):1955-65. PubMed ID: 7783127
[TBL] [Abstract][Full Text] [Related]
10. Tricyclic indole-2-carboxylic acids: highly in vivo active and selective antagonists for the glycine binding site of the NMDA receptor.
Katayama S; Ae N; Kodo T; Masumoto S; Hourai S; Tamamura C; Tanaka H; Nagata R
J Med Chem; 2003 Feb; 46(5):691-701. PubMed ID: 12593650
[TBL] [Abstract][Full Text] [Related]
11. Regionally different N-methyl-D-aspartate receptors distinguished by ligand binding and quantitative autoradiography of [3H]-CGP 39653 in rat brain.
Mugnaini M; van Amsterdam FT; Ratti E; Trist DG; Bowery NG
Br J Pharmacol; 1996 Nov; 119(5):819-28. PubMed ID: 8922727
[TBL] [Abstract][Full Text] [Related]
12. Blockade of NMDA receptors in the nucleus accumbens elicits spontaneous tail-flicks in rats.
Millan MJ; Audinot V; Honoré P; Bervoets K; Veiga S; Brocco M
Eur J Pharmacol; 2000 Jan; 388(1):37-47. PubMed ID: 10657545
[TBL] [Abstract][Full Text] [Related]
13. Structure-activity relationships in a series of 2(1H)-quinolones bearing different acidic function in the 3-position: 6,7-dichloro-2(1H)-oxoquinoline-3-phosphonic acid, a new potent and selective AMPA/kainate antagonist with neuroprotective properties.
Desos P; Lepagnol JM; Morain P; Lestage P; Cordi AA
J Med Chem; 1996 Jan; 39(1):197-206. PubMed ID: 8568808
[TBL] [Abstract][Full Text] [Related]
14. Synthesis of 1,4,7,8,9,10-hexahydro-9-methyl-6-nitropyrido[3,4-f]- quinoxaline-2,3-dione and related quinoxalinediones: characterization of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (and N-methyl-D-aspartate) receptor and anticonvulsant activity.
Bigge CF; Malone TC; Boxer PA; Nelson CB; Ortwine DF; Schelkun RM; Retz DM; Lescosky LJ; Borosky SA; Vartanian MG
J Med Chem; 1995 Sep; 38(19):3720-40. PubMed ID: 7562904
[TBL] [Abstract][Full Text] [Related]
15. Subtype-selective N-methyl-D-aspartate receptor antagonists: synthesis and biological evaluation of 1-(heteroarylalkynyl)-4-benzylpiperidines.
Wright JL; Gregory TF; Kesten SR; Boxer PA; Serpa KA; Meltzer LT; Wise LD; Espitia SA; Konkoy CS; Whittemore ER; Woodward RM
J Med Chem; 2000 Sep; 43(18):3408-19. PubMed ID: 10978188
[TBL] [Abstract][Full Text] [Related]
16. Subtype-selective N-methyl-D-aspartate receptor antagonists: benzimidazalone and hydantoin as phenol replacements.
Schelkun RM; Yuen PW; Serpa K; Meltzer LT; Wise LD; Whittemore ER; Woodward RM
J Med Chem; 2000 May; 43(9):1892-7. PubMed ID: 10794706
[TBL] [Abstract][Full Text] [Related]
17. Pharmacological characterization of Ro 63-1908 (1-[2-(4-hydroxy-phenoxy)-ethyl]-4-(4-methyl-benzyl)-piperidin-4-ol), a novel subtype-selective N-methyl-D-aspartate antagonist.
Gill R; Alanine A; Bourson A; Buttelmann B; Fischer G; Heitz MP; Kew JN; Levet-Trafit B; Lorez HP; Malherbe P; Miss MT; Mutel V; Pinard E; Roever S; Schmitt M; Trube G; Wybrecht R; Wyler R; Kemp JA
J Pharmacol Exp Ther; 2002 Sep; 302(3):940-8. PubMed ID: 12183650
[TBL] [Abstract][Full Text] [Related]
18. The competitive NMDA receptor antagonist SDZ 220-581 reverses haloperidol-induced catalepsy in rats.
McAllister KH
Eur J Pharmacol; 1996 Oct; 314(3):307-11. PubMed ID: 8957251
[TBL] [Abstract][Full Text] [Related]
19. Synthesis of a series of γ-amino alcohols comprising an N-methyl isoindoline moiety and their evaluation as NMDA receptor antagonists.
Müller A; Höfner G; Renukappa-Gutke T; Parsons CG; Wanner KT
Bioorg Med Chem Lett; 2011 Oct; 21(19):5795-9. PubMed ID: 21875803
[TBL] [Abstract][Full Text] [Related]
20. Evaluation of glycine site antagonists of the NMDA receptor in global cerebral ischaemia.
Hicks CA; Ward MA; Ragumoorthy N; Ambler SJ; Dell CP; Dobson D; O'Neill MJ
Brain Res; 1999 Feb; 819(1-2):65-74. PubMed ID: 10082862
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]