These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

292 related articles for article (PubMed ID: 11353759)

  • 1. Bioactivation of tamoxifen to metabolite E quinone methide: reaction with glutathione and DNA.
    Fan PW; Bolton JL
    Drug Metab Dispos; 2001 Jun; 29(6):891-6. PubMed ID: 11353759
    [TBL] [Abstract][Full Text] [Related]  

  • 2. 4-Hydroxylated metabolites of the antiestrogens tamoxifen and toremifene are metabolized to unusually stable quinone methides.
    Fan PW; Zhang F; Bolton JL
    Chem Res Toxicol; 2000 Jan; 13(1):45-52. PubMed ID: 10649966
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Bioactivation of the selective estrogen receptor modulator acolbifene to quinone methides.
    Liu J; Liu H; van Breemen RB; Thatcher GR; Bolton JL
    Chem Res Toxicol; 2005 Feb; 18(2):174-82. PubMed ID: 15720121
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Bioactivation of estrone and its catechol metabolites to quinoid-glutathione conjugates in rat liver microsomes.
    Iverson SL; Shen L; Anlar N; Bolton JL
    Chem Res Toxicol; 1996 Mar; 9(2):492-9. PubMed ID: 8839054
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Identification of tamoxifen-DNA adducts formed by 4-hydroxytamoxifen quinone methide.
    Marques MM; Beland FA
    Carcinogenesis; 1997 Oct; 18(10):1949-54. PubMed ID: 9364005
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis and reactivity of a potential carcinogenic metabolite of tamoxifen: 3,4-dihydroxytamoxifen-o-quinone.
    Zhang F; Fan PW; Liu X; Shen L; van Breemen RB; Bolton JL
    Chem Res Toxicol; 2000 Jan; 13(1):53-62. PubMed ID: 10649967
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Bioactivation of phencyclidine in rat and human liver microsomes and recombinant P450 2B enzymes: evidence for the formation of a novel quinone methide intermediate.
    Driscoll JP; Kornecki K; Wolkowski JP; Chupak L; Kalgutkar AS; O'Donnell JP
    Chem Res Toxicol; 2007 Oct; 20(10):1488-97. PubMed ID: 17892269
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis and reactivity of potential toxic metabolites of tamoxifen analogues: droloxifene and toremifene o-quinones.
    Yao D; Zhang F; Yu L; Yang Y; van Breemen RB; Bolton JL
    Chem Res Toxicol; 2001 Dec; 14(12):1643-53. PubMed ID: 11743747
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Oxo substituents markedly alter the phase II metabolism of alpha-hydroxybutenylbenzenes: models probing the bioactivation mechanisms of tamoxifen.
    Ramakrishna KV; Fan PW; Boyer CS; Dalvie D; Bolton JL
    Chem Res Toxicol; 1997 Aug; 10(8):887-94. PubMed ID: 9282838
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The major metabolite of equilin, 4-hydroxyequilin, autoxidizes to an o-quinone which isomerizes to the potent cytotoxin 4-hydroxyequilenin-o-quinone.
    Zhang F; Chen Y; Pisha E; Shen L; Xiong Y; van Breemen RB; Bolton JL
    Chem Res Toxicol; 1999 Feb; 12(2):204-13. PubMed ID: 10027800
    [TBL] [Abstract][Full Text] [Related]  

  • 11. NADPH-dependent covalent binding of [3H]paroxetine to human liver microsomes and S-9 fractions: identification of an electrophilic quinone metabolite of paroxetine.
    Zhao SX; Dalvie DK; Kelly JM; Soglia JR; Frederick KS; Smith EB; Obach RS; Kalgutkar AS
    Chem Res Toxicol; 2007 Nov; 20(11):1649-57. PubMed ID: 17907785
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Activation of the tamoxifen derivative metabolite E to form DNA adducts: comparison with the adducts formed by microsomal activation of tamoxifen.
    Pongracz K; Pathak DN; Nakamura T; Burlingame AL; Bodell WJ
    Cancer Res; 1995 Jul; 55(14):3012-5. PubMed ID: 7606720
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Bioactivation of the selective estrogen receptor modulator desmethylated arzoxifene to quinoids: 4'-fluoro substitution prevents quinoid formation.
    Liu H; Liu J; van Breemen RB; Thatcher GR; Bolton JL
    Chem Res Toxicol; 2005 Feb; 18(2):162-73. PubMed ID: 15720120
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Antiestrogenic and DNA damaging effects induced by tamoxifen and toremifene metabolites.
    Liu X; Pisha E; Tonetti DA; Yao D; Li Y; Yao J; Burdette JE; Bolton JL
    Chem Res Toxicol; 2003 Jul; 16(7):832-7. PubMed ID: 12870885
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Bioactivation of the cancer chemopreventive agent tamoxifen to quinone methides by cytochrome P4502B6 and identification of the modified residue on the apoprotein.
    Sridar C; D'Agostino J; Hollenberg PF
    Drug Metab Dispos; 2012 Dec; 40(12):2280-8. PubMed ID: 22942317
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Identification and characterization of novel stable deoxyguanosine and deoxyadenosine adducts of benzo[a]pyrene-7,8-quinone from reactions at physiological pH.
    Balu N; Padgett WT; Lambert GR; Swank AE; Richard AM; Nesnow S
    Chem Res Toxicol; 2004 Jun; 17(6):827-38. PubMed ID: 15206904
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Regioselectivity and reversibility of the glutathione conjugation of quercetin quinone methide.
    Boersma MG; Vervoort J; Szymusiak H; Lemanska K; Tyrakowska B; Cenas N; Segura-Aguilar J; Rietjens IM
    Chem Res Toxicol; 2000 Mar; 13(3):185-91. PubMed ID: 10725115
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Quantification of tamoxifen DNA adducts using on-line sample preparation and HPLC-electrospray ionization tandem mass spectrometry.
    Gamboa da Costa G; Marques MM; Beland FA; Freeman JP; Churchwell MI; Doerge DR
    Chem Res Toxicol; 2003 Mar; 16(3):357-66. PubMed ID: 12641436
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Inhibition of mitochondrial respiration by a para-quinone methide.
    Thompson DC; Perera K
    Biochem Biophys Res Commun; 1995 Apr; 209(1):6-11. PubMed ID: 7726864
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The influence of the p-alkyl substituent on the isomerization of o-quinones to p-quinone methides: potential bioactivation mechanism for catechols.
    Iverson SL; Hu LQ; Vukomanovic V; Bolton JL
    Chem Res Toxicol; 1995 Jun; 8(4):537-44. PubMed ID: 7548733
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.