These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

147 related articles for article (PubMed ID: 11356825)

  • 1. Cysteines 431 and 1074 are responsible for inhibitory disulfide cross-linking between the two nucleotide-binding sites in human P-glycoprotein.
    Urbatsch IL; Gimi K; Wilke-Mounts S; Lerner-Marmarosh N; Rousseau ME; Gros P; Senior AE
    J Biol Chem; 2001 Jul; 276(29):26980-7. PubMed ID: 11356825
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Drug-stimulated ATPase activity of human P-glycoprotein is blocked by disulfide cross-linking between the nucleotide-binding sites.
    Loo TW; Clarke DM
    J Biol Chem; 2000 Jun; 275(26):19435-8. PubMed ID: 10806188
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Covalent modification of human P-glycoprotein mutants containing a single cysteine in either nucleotide-binding fold abolishes drug-stimulated ATPase activity.
    Loo TW; Clarke DM
    J Biol Chem; 1995 Sep; 270(39):22957-61. PubMed ID: 7559432
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Inhibition of oxidative cross-linking between engineered cysteine residues at positions 332 in predicted transmembrane segments (TM) 6 and 975 in predicted TM12 of human P-glycoprotein by drug substrates.
    Loo TW; Clarke DM
    J Biol Chem; 1996 Nov; 271(44):27482-7. PubMed ID: 8910331
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Disulfide cross-linking analysis shows that transmembrane segments 5 and 8 of human P-glycoprotein are close together on the cytoplasmic side of the membrane.
    Loo TW; Bartlett MC; Clarke DM
    J Biol Chem; 2004 Feb; 279(9):7692-7. PubMed ID: 14670948
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The "LSGGQ" motif in each nucleotide-binding domain of human P-glycoprotein is adjacent to the opposing walker A sequence.
    Loo TW; Bartlett MC; Clarke DM
    J Biol Chem; 2002 Nov; 277(44):41303-6. PubMed ID: 12226074
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Cysteines introduced into extracellular loops 1 and 4 of human P-glycoprotein that are close only in the open conformation spontaneously form a disulfide bond that inhibits drug efflux and ATPase activity.
    Loo TW; Clarke DM
    J Biol Chem; 2014 Sep; 289(36):24749-58. PubMed ID: 25053414
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Nucleotide-induced conformational changes in P-glycoprotein and in nucleotide binding site mutants monitored by trypsin sensitivity.
    Julien M; Gros P
    Biochemistry; 2000 Apr; 39(15):4559-68. PubMed ID: 10758006
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Rapid purification of human P-glycoprotein mutants expressed transiently in HEK 293 cells by nickel-chelate chromatography and characterization of their drug-stimulated ATPase activities.
    Loo TW; Clarke DM
    J Biol Chem; 1995 Sep; 270(37):21449-52. PubMed ID: 7665554
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Cloning, overexpression, purification, and characterization of the carboxyl-terminal nucleotide binding domain of P-glycoprotein.
    Sharma S; Rose DR
    J Biol Chem; 1995 Jun; 270(23):14085-93. PubMed ID: 7775470
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Permanent activation of the human P-glycoprotein by covalent modification of a residue in the drug-binding site.
    Loo TW; Bartlett MC; Clarke DM
    J Biol Chem; 2003 Jun; 278(23):20449-52. PubMed ID: 12711602
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Mechanism of action of human P-glycoprotein ATPase activity. Photochemical cleavage during a catalytic transition state using orthovanadate reveals cross-talk between the two ATP sites.
    Hrycyna CA; Ramachandra M; Ambudkar SV; Ko YH; Pedersen PL; Pastan I; Gottesman MM
    J Biol Chem; 1998 Jul; 273(27):16631-4. PubMed ID: 9642211
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Conserved Walker A cysteines 431 and 1074 in human P-glycoprotein are accessible to thiol-specific agents in the apo and ADP-vanadate trapped conformations.
    Sim HM; Bhatnagar J; Chufan EE; Kapoor K; Ambudkar SV
    Biochemistry; 2013 Oct; 52(41):7327-38. PubMed ID: 24053441
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Importance of cysteine residues for the stability and catalytic activity of human pancreatic beta cell glucokinase.
    Tiedge M; Richter T; Lenzen S
    Arch Biochem Biophys; 2000 Mar; 375(2):251-60. PubMed ID: 10700381
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Importance of the Cys
    Samainukul N; Linn AK; Javadi MB; Sakdee S; Angsuthanasombat C; Katzenmeier G
    Biochem Biophys Res Commun; 2019 Jun; 514(2):365-371. PubMed ID: 31040022
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Mutational analysis of conserved carboxylate residues in the nucleotide binding sites of P-glycoprotein.
    Urbatsch IL; Julien M; Carrier I; Rousseau ME; Cayrol R; Gros P
    Biochemistry; 2000 Nov; 39(46):14138-49. PubMed ID: 11087362
    [TBL] [Abstract][Full Text] [Related]  

  • 17. FRET analysis indicates that the two ATPase active sites of the P-glycoprotein multidrug transporter are closely associated.
    Qu Q; Sharom FJ
    Biochemistry; 2001 Feb; 40(5):1413-22. PubMed ID: 11170469
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Simple purification of highly active biotinylated P-glycoprotein: enantiomer-specific modulation of drug-stimulated ATPase activity.
    Julien M; Kajiji S; Kaback RH; Gros P
    Biochemistry; 2000 Jan; 39(1):75-85. PubMed ID: 10625481
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Recombinant N-terminal nucleotide-binding domain from mouse P-glycoprotein. Overexpression, purification, and role of cysteine 430.
    Dayan G; Baubichon-Cortay H; Jault JM; Cortay JC; Deléage G; Di Pietro A
    J Biol Chem; 1996 May; 271(20):11652-8. PubMed ID: 8662620
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Mutations in either nucleotide-binding site of P-glycoprotein (Mdr3) prevent vanadate trapping of nucleotide at both sites.
    Urbatsch IL; Beaudet L; Carrier I; Gros P
    Biochemistry; 1998 Mar; 37(13):4592-602. PubMed ID: 9521779
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.