266 related articles for article (PubMed ID: 11368333)
1. Characterization of cytochrome P450 2A4 and 2A5-catalyzed 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism.
Felicia ND; Rekha GK; Murphy SE
Arch Biochem Biophys; 2000 Dec; 384(2):418-24. PubMed ID: 11368333
[TBL] [Abstract][Full Text] [Related]
2. Comparative metabolism of the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol by rat cytochrome P450 2A3 and human cytochrome P450 2A13.
Jalas JR; Ding X; Murphy SE
Drug Metab Dispos; 2003 Oct; 31(10):1199-202. PubMed ID: 12975327
[TBL] [Abstract][Full Text] [Related]
3. Synthesis of stereospecifically deuterated 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) iastereomers and metabolism by A/J mouse lung microsomes and cytochrome p450 2A5.
Jalas JR; Hecht SS
Chem Res Toxicol; 2003 Jun; 16(6):782-93. PubMed ID: 12807362
[TBL] [Abstract][Full Text] [Related]
4. Stereospecific deuterium substitution attenuates the tumorigenicity and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
Jalas JR; McIntee EJ; Kenney PM; Upadhyaya P; Peterson LA; Hecht SS
Chem Res Toxicol; 2003 Jun; 16(6):794-806. PubMed ID: 12807363
[TBL] [Abstract][Full Text] [Related]
5. Kinetic analysis of the activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by heterologously expressed human P450 enzymes and the effect of P450-specific chemical inhibitors on this activation in human liver microsomes.
Patten CJ; Smith TJ; Murphy SE; Wang MH; Lee J; Tynes RE; Koch P; Yang CS
Arch Biochem Biophys; 1996 Sep; 333(1):127-38. PubMed ID: 8806763
[TBL] [Abstract][Full Text] [Related]
6. Evidence for cytochrome P450 2A6 and 3A4 as major catalysts for N'-nitrosonornicotine alpha-hydroxylation by human liver microsomes.
Patten CJ; Smith TJ; Friesen MJ; Tynes RE; Yang CS; Murphy SE
Carcinogenesis; 1997 Aug; 18(8):1623-30. PubMed ID: 9276639
[TBL] [Abstract][Full Text] [Related]
7. Evidence for metabolic activation of N'-nitrosonornicotine and N-nitrosobenzylmethylamine by a rat nasal coumarin hydroxylase.
Patten CJ; Peterson LA; Murphy SE
Drug Metab Dispos; 1998 Feb; 26(2):177-80. PubMed ID: 9456305
[TBL] [Abstract][Full Text] [Related]
8. Cytochrome P450 2A-catalyzed metabolic activation of structurally similar carcinogenic nitrosamines: N'-nitrosonornicotine enantiomers, N-nitrosopiperidine, and N-nitrosopyrrolidine.
Wong HL; Murphy SE; Hecht SS
Chem Res Toxicol; 2005 Jan; 18(1):61-9. PubMed ID: 15651850
[TBL] [Abstract][Full Text] [Related]
9. N-Nitrosobenzylmethylamine hydroxylation and coumarin 7-hydroxylation: catalysis by rat esophageal microsomes and cytochrome P450 2A3 and 2A6 enzymes.
von Weymarn LB; Felicia ND; Ding X; Murphy SE
Chem Res Toxicol; 1999 Dec; 12(12):1254-61. PubMed ID: 10604876
[TBL] [Abstract][Full Text] [Related]
10. Specificity of cytochrome P450 2A3-catalyzed alpha-hydroxylation of N'-nitrosonornicotine enantiomers.
Murphy SE; Isaac IS; Ding X; McIntee EJ
Drug Metab Dispos; 2000 Nov; 28(11):1263-6. PubMed ID: 11038149
[TBL] [Abstract][Full Text] [Related]
11. Metabolic activation of the tobacco carcinogen 4-(methylnitrosamino)-(3-pyridyl)-1-butanone by cytochrome P450 2A13 in human fetal nasal microsomes.
Wong HL; Zhang X; Zhang QY; Gu J; Ding X; Hecht SS; Murphy SE
Chem Res Toxicol; 2005 Jun; 18(6):913-8. PubMed ID: 15962925
[TBL] [Abstract][Full Text] [Related]
12. Activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in human lung microsomes by cytochromes P450, lipoxygenase, and hydroperoxides.
Smith TJ; Stoner GD; Yang CS
Cancer Res; 1995 Dec; 55(23):5566-73. PubMed ID: 7585636
[TBL] [Abstract][Full Text] [Related]
13. Analysis of CYP2A contributions to metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human peripheral lung microsomes.
Brown PJ; Bedard LL; Reid KR; Petsikas D; Massey TE
Drug Metab Dispos; 2007 Nov; 35(11):2086-94. PubMed ID: 17717079
[TBL] [Abstract][Full Text] [Related]
14. Mechanisms of chemopreventive effects of 8-methoxypsoralen against 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung adenomas.
Miyazaki M; Yamazaki H; Takeuchi H; Saoo K; Yokohira M; Masumura K; Nohmi T; Funae Y; Imaida K; Kamataki T
Carcinogenesis; 2005 Nov; 26(11):1947-55. PubMed ID: 15958517
[TBL] [Abstract][Full Text] [Related]
15. Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-butanone metabolism by cytochrome P450 2B6.
Dicke KE; Skrlin SM; Murphy SE
Drug Metab Dispos; 2005 Dec; 33(12):1760-4. PubMed ID: 16174803
[TBL] [Abstract][Full Text] [Related]
16. Human CYP2A6 activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK): mutational specificity in the gpt gene of AS52 cells.
Tiano HF; Wang RL; Hosokawa M; Crespi C; Tindall KR; Langenbach R
Carcinogenesis; 1994 Dec; 15(12):2859-66. PubMed ID: 8001247
[TBL] [Abstract][Full Text] [Related]
17. Enzymes involved in the bioactivation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in patas monkey lung and liver microsomes.
Smith TJ; Liao AM; Liu Y; Jones AB; Anderson LM; Yang CS
Carcinogenesis; 1997 Aug; 18(8):1577-84. PubMed ID: 9276633
[TBL] [Abstract][Full Text] [Related]
18. Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human lung and liver microsomes and cytochromes P-450 expressed in hepatoma cells.
Smith TJ; Guo Z; Gonzalez FJ; Guengerich FP; Stoner GD; Yang CS
Cancer Res; 1992 Apr; 52(7):1757-63. PubMed ID: 1312898
[TBL] [Abstract][Full Text] [Related]
19. Identification of critical amino acid residues of human CYP2A13 for the metabolic activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco-specific carcinogen.
He XY; Shen J; Ding X; Lu AY; Hong JY
Drug Metab Dispos; 2004 Dec; 32(12):1516-21. PubMed ID: 15333516
[TBL] [Abstract][Full Text] [Related]
20. Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) by human cytochrome P450 1A2 and its inhibition by phenethyl isothiocyanate.
Smith TJ; Guo Z; Guengerich FP; Yang CS
Carcinogenesis; 1996 Apr; 17(4):809-13. PubMed ID: 8625495
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]