These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
2. Identification of basic residues in the heparin-binding exosite of factor Xa critical for heparin and factor Va binding. Rezaie AR J Biol Chem; 2000 Feb; 275(5):3320-7. PubMed ID: 10652320 [TBL] [Abstract][Full Text] [Related]
3. Calcium enhances heparin catalysis of the antithrombin-factor Xa reaction by promoting the assembly of an intermediate heparin-antithrombin-factor Xa bridging complex. Demonstration by rapid kinetics studies. Rezaie AR; Olson ST Biochemistry; 2000 Oct; 39(39):12083-90. PubMed ID: 11009624 [TBL] [Abstract][Full Text] [Related]
4. Conformational activation of antithrombin by heparin involves an altered exosite interaction with protease. Izaguirre G; Aguila S; Qi L; Swanson R; Roth R; Rezaie AR; Gettins PG; Olson ST J Biol Chem; 2014 Dec; 289(49):34049-64. PubMed ID: 25331949 [TBL] [Abstract][Full Text] [Related]
5. Probing the molecular basis of factor Xa specificity by mutagenesis of the serpin, antithrombin. Rezaie AR; Yang L Biochim Biophys Acta; 2001 Oct; 1528(2-3):167-76. PubMed ID: 11687304 [TBL] [Abstract][Full Text] [Related]
6. Heparin enhances the specificity of antithrombin for thrombin and factor Xa independent of the reactive center loop sequence. Evidence for an exosite determinant of factor Xa specificity in heparin-activated antithrombin. Chuang YJ; Swanson R; Raja SM; Olson ST J Biol Chem; 2001 May; 276(18):14961-71. PubMed ID: 11278930 [TBL] [Abstract][Full Text] [Related]
7. Exosite binding tethers the macromolecular substrate to the prothrombinase complex and directs cleavage at two spatially distinct sites. Boskovic DS; Krishnaswamy S J Biol Chem; 2000 Dec; 275(49):38561-70. PubMed ID: 10984491 [TBL] [Abstract][Full Text] [Related]
8. Functional mapping of charged residues of the 82-116 sequence in factor Xa: evidence that lysine 96 is a factor Va independent recognition site for prothrombin in the prothrombinase complex. Manithody C; Rezaie AR Biochemistry; 2005 Aug; 44(30):10063-70. PubMed ID: 16042383 [TBL] [Abstract][Full Text] [Related]
9. Role of basic residues of the autolysis loop in the catalytic function of factor Xa. Manithody C; Yang L; Rezaie AR Biochemistry; 2002 May; 41(21):6780-8. PubMed ID: 12022882 [TBL] [Abstract][Full Text] [Related]
10. Conformational equilibrium of the reactive center loop of antithrombin examined by steady state and time-resolved fluorescence measurements: consequences for the mechanism of factor Xa inhibition by antithrombin-heparin complexes. Futamura A; Beechem JM; Gettins PG Biochemistry; 2001 Jun; 40(22):6680-7. PubMed ID: 11380263 [TBL] [Abstract][Full Text] [Related]
11. Prothrombin protects factor Xa in the prothrombinase complex from inhibition by the heparin-antithrombin complex. Rezaie AR Blood; 2001 Apr; 97(8):2308-13. PubMed ID: 11290592 [TBL] [Abstract][Full Text] [Related]
12. Ixolaris: a factor Xa heparin-binding exosite inhibitor. Monteiro RQ; Rezaie AR; Ribeiro JM; Francischetti IM Biochem J; 2005 May; 387(Pt 3):871-7. PubMed ID: 15617517 [TBL] [Abstract][Full Text] [Related]
13. Effects of Ca2+ binding on the protease module of factor Xa and its interaction with factor Va. Evidence for two Gla-independent Ca(2+)-binding sites in factor Xa. Persson E; Hogg PJ; Stenflo J J Biol Chem; 1993 Oct; 268(30):22531-9. PubMed ID: 8226763 [TBL] [Abstract][Full Text] [Related]
14. The contribution of factor Xa to exosite-dependent substrate recognition by prothrombinase. Wilkens M; Krishnaswamy S J Biol Chem; 2002 Mar; 277(11):9366-74. PubMed ID: 11782479 [TBL] [Abstract][Full Text] [Related]
15. Mechanism by which exosites promote the inhibition of blood coagulation proteases by heparin-activated antithrombin. Izaguirre G; Swanson R; Raja SM; Rezaie AR; Olson ST J Biol Chem; 2007 Nov; 282(46):33609-33622. PubMed ID: 17875649 [TBL] [Abstract][Full Text] [Related]
16. Mechanism of inhibition of the prothrombinase complex by a covalent antithrombin-heparin complex. Stevic I; Berry LR; Chan AK J Biochem; 2012 Aug; 152(2):139-48. PubMed ID: 22518847 [TBL] [Abstract][Full Text] [Related]
18. The critical role of the 185-189-loop in the factor Xa interaction with Na+ and factor Va in the prothrombinase complex. Rezaie AR; Kittur FS J Biol Chem; 2004 Nov; 279(46):48262-9. PubMed ID: 15347660 [TBL] [Abstract][Full Text] [Related]
19. Identification of a binding site for blood coagulation factor Xa on the heavy chain of factor Va. Amino acid residues 323-331 of factor V represent an interactive site for activated factor X. Kalafatis M; Beck DO Biochemistry; 2002 Oct; 41(42):12715-28. PubMed ID: 12379114 [TBL] [Abstract][Full Text] [Related]
20. Engineering functional antithrombin exosites in alpha1-proteinase inhibitor that specifically promote the inhibition of factor Xa and factor IXa. Izaguirre G; Rezaie AR; Olson ST J Biol Chem; 2009 Jan; 284(3):1550-8. PubMed ID: 19010776 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]