BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

1006 related articles for article (PubMed ID: 11406613)

  • 1. BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics.
    Roberds SL; Anderson J; Basi G; Bienkowski MJ; Branstetter DG; Chen KS; Freedman SB; Frigon NL; Games D; Hu K; Johnson-Wood K; Kappenman KE; Kawabe TT; Kola I; Kuehn R; Lee M; Liu W; Motter R; Nichols NF; Power M; Robertson DW; Schenk D; Schoor M; Shopp GM; Shuck ME; Sinha S; Svensson KA; Tatsuno G; Tintrup H; Wijsman J; Wright S; McConlogue L
    Hum Mol Genet; 2001 Jun; 10(12):1317-24. PubMed ID: 11406613
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE.
    Vassar R; Bennett BD; Babu-Khan S; Kahn S; Mendiaz EA; Denis P; Teplow DB; Ross S; Amarante P; Loeloff R; Luo Y; Fisher S; Fuller J; Edenson S; Lile J; Jarosinski MA; Biere AL; Curran E; Burgess T; Louis JC; Collins F; Treanor J; Rogers G; Citron M
    Science; 1999 Oct; 286(5440):735-41. PubMed ID: 10531052
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Amyloid precursor protein compartmentalization restricts beta-amyloid production: therapeutic targets based on BACE compartmentalization.
    Gandhi S; Refolo LM; Sambamurti K
    J Mol Neurosci; 2004; 24(1):137-43. PubMed ID: 15314262
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The beta-secretase, BACE: a prime drug target for Alzheimer's disease.
    Vassar R
    J Mol Neurosci; 2001 Oct; 17(2):157-70. PubMed ID: 11816789
    [TBL] [Abstract][Full Text] [Related]  

  • 5. BACE1: the beta-secretase enzyme in Alzheimer's disease.
    Vassar R
    J Mol Neurosci; 2004; 23(1-2):105-14. PubMed ID: 15126696
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Gleevec shifts APP processing from a β-cleavage to a nonamyloidogenic cleavage.
    Netzer WJ; Bettayeb K; Sinha SC; Flajolet M; Greengard P; Bustos V
    Proc Natl Acad Sci U S A; 2017 Feb; 114(6):1389-1394. PubMed ID: 28115709
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Beta-secretase processing of the Alzheimer's amyloid protein precursor (APP).
    Marlow L; Cain M; Pappolla MA; Sambamurti K
    J Mol Neurosci; 2003; 20(3):233-9. PubMed ID: 14501002
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo.
    Hussain I; Hawkins J; Harrison D; Hille C; Wayne G; Cutler L; Buck T; Walter D; Demont E; Howes C; Naylor A; Jeffrey P; Gonzalez MI; Dingwall C; Michel A; Redshaw S; Davis JB
    J Neurochem; 2007 Feb; 100(3):802-9. PubMed ID: 17156133
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Age-dependent differential expression of BACE splice variants in brain regions of tg2576 mice.
    Zohar O; Pick CG; Cavallaro S; Chapman J; Katzav A; Milman A; Alkon DL
    Neurobiol Aging; 2005; 26(8):1167-75. PubMed ID: 15917100
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Beta-amyloid peptide in regulated secretory vesicles of chromaffin cells: evidence for multiple cysteine proteolytic activities in distinct pathways for beta-secretase activity in chromaffin vesicles.
    Hook VY; Toneff T; Aaron W; Yasothornsrikul S; Bundey R; Reisine T
    J Neurochem; 2002 Apr; 81(2):237-56. PubMed ID: 12064471
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Expression and activity of beta-site amyloid precursor protein cleaving enzyme in Alzheimer's disease.
    Johnston JA; Liu WW; Todd SA; Coulson DT; Murphy S; Irvine GB; Passmore AP
    Biochem Soc Trans; 2005 Nov; 33(Pt 5):1096-100. PubMed ID: 16246054
    [TBL] [Abstract][Full Text] [Related]  

  • 12. BACE (beta-secretase) modulates the processing of APLP2 in vivo.
    Pastorino L; Ikin AF; Lamprianou S; Vacaresse N; Revelli JP; Platt K; Paganetti P; Mathews PM; Harroch S; Buxbaum JD
    Mol Cell Neurosci; 2004 Apr; 25(4):642-9. PubMed ID: 15080893
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Combining an amyloid-beta (Aβ) cleaving enzyme inhibitor with a γ-secretase modulator results in an additive reduction of Aβ production.
    Strömberg K; Eketjäll S; Georgievska B; Tunblad K; Eliason K; Olsson F; Radesäter AC; Klintenberg R; Arvidsson PI; von Berg S; Fälting J; Cowburn RF; Dabrowski M
    FEBS J; 2015 Jan; 282(1):65-73. PubMed ID: 25303711
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Inhibiting β-secretase activity in Alzheimer's disease cell models with single-chain antibodies specifically targeting APP.
    Boddapati S; Levites Y; Sierks MR
    J Mol Biol; 2011 Jan; 405(2):436-47. PubMed ID: 21073877
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients.
    Li R; Lindholm K; Yang LB; Yue X; Citron M; Yan R; Beach T; Sue L; Sabbagh M; Cai H; Wong P; Price D; Shen Y
    Proc Natl Acad Sci U S A; 2004 Mar; 101(10):3632-7. PubMed ID: 14978286
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis.
    Deng Y; Wang Z; Wang R; Zhang X; Zhang S; Wu Y; Staufenbiel M; Cai F; Song W
    Eur J Neurosci; 2013 Jun; 37(12):1962-9. PubMed ID: 23773065
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease.
    Fukumoto H; Cheung BS; Hyman BT; Irizarry MC
    Arch Neurol; 2002 Sep; 59(9):1381-9. PubMed ID: 12223024
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Beta-secretase (BACE) as a drug target for Alzheimer's disease.
    Vassar R
    Adv Drug Deliv Rev; 2002 Dec; 54(12):1589-602. PubMed ID: 12453676
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Effects of TNFalpha-converting enzyme inhibition on amyloid beta production and APP processing in vitro and in vivo.
    Kim ML; Zhang B; Mills IP; Milla ME; Brunden KR; Lee VM
    J Neurosci; 2008 Nov; 28(46):12052-61. PubMed ID: 19005070
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Neuronal and glial beta-secretase (BACE) protein expression in transgenic Tg2576 mice with amyloid plaque pathology.
    Rossner S; Apelt J; Schliebs R; Perez-Polo JR; Bigl V
    J Neurosci Res; 2001 Jun; 64(5):437-46. PubMed ID: 11391698
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 51.