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6. Small molecules that mimic the thiol-triggered alkylating properties seen in the natural product leinamycin. Chatterji T; Kizil M; Keerthi K; Chowdhury G; PospĂsil T; Gates KS J Am Chem Soc; 2003 Apr; 125(17):4996-7. PubMed ID: 12708847 [TBL] [Abstract][Full Text] [Related]
7. Thiol-dependent DNA cleavage by 3H-1,2-benzodithiol-3-one 1,1-dioxide. Breydo L; Gates KS Bioorg Med Chem Lett; 2000 May; 10(9):885-9. PubMed ID: 10853652 [TBL] [Abstract][Full Text] [Related]
8. Activation of leinamycin by thiols: a theoretical study. Breydo L; Gates KS J Org Chem; 2002 Dec; 67(25):9054-60. PubMed ID: 12467428 [TBL] [Abstract][Full Text] [Related]
9. DNA strand scission by the novel antitumor antibiotic leinamycin. Hara M; Saitoh Y; Nakano H Biochemistry; 1990 Jun; 29(24):5676-81. PubMed ID: 2383554 [TBL] [Abstract][Full Text] [Related]
10. Mechanisms of DNA damage by leinamycin. Gates KS Chem Res Toxicol; 2000 Oct; 13(10):953-6. PubMed ID: 11080040 [No Abstract] [Full Text] [Related]
11. Cellular response and molecular mechanism of antitumor activity by leinamycin in MiaPaCa human pancreatic cancer cells. Bassett S; Urrabaz R; Sun D Anticancer Drugs; 2004 Aug; 15(7):689-96. PubMed ID: 15269600 [TBL] [Abstract][Full Text] [Related]
12. Synthesis and characterization of a small analogue of the anticancer natural product leinamycin. Keerthi K; Rajapakse A; Sun D; Gates KS Bioorg Med Chem; 2013 Jan; 21(1):235-41. PubMed ID: 23168080 [TBL] [Abstract][Full Text] [Related]
13. Chemical properties of the leinamycin-guanine adduct in DNA. Nooner T; Dutta S; Gates KS Chem Res Toxicol; 2004 Jul; 17(7):942-9. PubMed ID: 15257620 [TBL] [Abstract][Full Text] [Related]
14. Attractive through-space S-O interaction in the DNA-cleaving antitumor antibiotic leinamycin. Wu S; Greer A J Org Chem; 2000 Aug; 65(16):4883-7. PubMed ID: 10956467 [TBL] [Abstract][Full Text] [Related]
15. Noncovalent DNA binding drives DNA alkylation by leinamycin: evidence that the Z,E-5-(thiazol-4-yl)-penta-2,4-dienone moiety of the natural product serves as an atypical DNA intercalator. Fekry MI; Szekely J; Dutta S; Breydo L; Zang H; Gates KS J Am Chem Soc; 2011 Nov; 133(44):17641-51. PubMed ID: 21954957 [TBL] [Abstract][Full Text] [Related]
17. Leinamycin, a new antitumor antibiotic from Streptomyces: producing organism, fermentation and isolation. Hara M; Asano K; Kawamoto I; Takiguchi T; Katsumata S; Takahashi K; Nakano H J Antibiot (Tokyo); 1989 Dec; 42(12):1768-74. PubMed ID: 2621160 [TBL] [Abstract][Full Text] [Related]
18. Characterization of DNA damage induced by a natural product antitumor antibiotic leinamycin in human cancer cells. Viswesh V; Gates K; Sun D Chem Res Toxicol; 2010 Jan; 23(1):99-107. PubMed ID: 20017514 [TBL] [Abstract][Full Text] [Related]
19. 1,2-Dithiolan-3-one 1-oxides: a class of thiol-activated DNA-cleaving agents that are structurally related to the natural product leinamycin. Behroozi SJ; Kim W; Dannaldson J; Gates KS Biochemistry; 1996 Feb; 35(6):1768-74. PubMed ID: 8639657 [TBL] [Abstract][Full Text] [Related]
20. DNA cleavage induced by antitumor antibiotic leinamycin and its biological consequences. Viswesh V; Hays AM; Gates K; Sun D Bioorg Med Chem; 2012 Jul; 20(14):4413-21. PubMed ID: 22682923 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]