These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

134 related articles for article (PubMed ID: 11448221)

  • 41. Synthesis of 2,4-diamino-6-[2'-O-(omega-carboxyalkyl)oxydibenz[b,f]azepin-5-yl]methylpteridines as potent and selective inhibitors of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium dihydrofolate reductase.
    Rosowsky A; Fu H; Chan DC; Queener SF
    J Med Chem; 2004 May; 47(10):2475-85. PubMed ID: 15115391
    [TBL] [Abstract][Full Text] [Related]  

  • 42. Inhibition of dihydrofolate reductases from Toxoplasma gondii, Pneumocystis carinii, and rat liver by rotationally restricted analogues of pyrimethamine and metoprine.
    Rosowsky A; Queener SF; Cody V
    Drug Des Discov; 1999 Jul; 16(1):25-40. PubMed ID: 10466054
    [TBL] [Abstract][Full Text] [Related]  

  • 43. Design, synthesis, biological evaluation and computational investigation of novel inhibitors of dihydrofolate reductase of opportunistic pathogens.
    Bag S; Tawari NR; Degani MS; Queener SF
    Bioorg Med Chem; 2010 May; 18(9):3187-97. PubMed ID: 20363634
    [TBL] [Abstract][Full Text] [Related]  

  • 44. Structure-activity correlations for three pyrido[2,3-d]pyrimidine antifolates binding to human and Pneumocystis carinii dihydrofolate reductase.
    Cody V; Pace J; Namjoshi OA; Gangjee A
    Acta Crystallogr F Struct Biol Commun; 2015 Jun; 71(Pt 6):799-803. PubMed ID: 26057816
    [TBL] [Abstract][Full Text] [Related]  

  • 45. Activity of antifolates against Pneumocystis carinii dihydrofolate reductase and identification of a potent new agent.
    Allegra CJ; Kovacs JA; Drake JC; Swan JC; Chabner BA; Masur H
    J Exp Med; 1987 Mar; 165(3):926-31. PubMed ID: 2950200
    [TBL] [Abstract][Full Text] [Related]  

  • 46. Inhibition of Pneumocystis dihydrofolate reductase by analogs of pyrimethamine, methotrexate and trimetrexate.
    Queener SF
    J Protozool; 1991; 38(6):154S-157S. PubMed ID: 1840146
    [TBL] [Abstract][Full Text] [Related]  

  • 47. Structure-activity and structure-selectivity studies on diaminoquinazolines and other inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase.
    Rosowsky A; Hynes JB; Queener SF
    Antimicrob Agents Chemother; 1995 Jan; 39(1):79-86. PubMed ID: 7695334
    [TBL] [Abstract][Full Text] [Related]  

  • 48. Synthesis and dihydrofolate reductase inhibitory activities of 2,4-diamino-5-deaza and 2,4-diamino-5,10-dideaza lipophilic antifolates.
    Gangjee A; Devraj R; Queener SF
    J Med Chem; 1997 Feb; 40(4):470-8. PubMed ID: 9046337
    [TBL] [Abstract][Full Text] [Related]  

  • 49. CoMFA/CoMSIA 3D-QSAR of pyrimidine inhibitors of Pneumocystis carinii dihydrofolate reductase.
    Santos-Filho OA; Forge D; Hoelz LV; de Freitas GB; Marinho TO; Araújo JQ; Albuquerque MG; de Alencastro RB; Boechat N
    J Mol Model; 2012 Sep; 18(9):4061-72. PubMed ID: 22527273
    [TBL] [Abstract][Full Text] [Related]  

  • 50. Synthesis and biological evaluation of biguanide and dihydrotriazine derivatives as potential inhibitors of dihydrofolate reductase of opportunistic microorganisms.
    Bag S; Tawari NR; Queener SF; Degani MS
    J Enzyme Inhib Med Chem; 2010 Jun; 25(3):331-9. PubMed ID: 19874136
    [TBL] [Abstract][Full Text] [Related]  

  • 51. Analysis of quinazoline and pyrido[2,3-d]pyrimidine N9-C10 reversed-bridge antifolates in complex with NADP+ and Pneumocystis carinii dihydrofolate reductase.
    Cody V; Galitsky N; Luft JR; Pangborn W; Queener SF; Gangjee A
    Acta Crystallogr D Biol Crystallogr; 2002 Sep; 58(Pt 9):1393-9. PubMed ID: 12198294
    [TBL] [Abstract][Full Text] [Related]  

  • 52. Development of substituted pyrido[3,2-d]pyrimidines as potent and selective dihydrofolate reductase inhibitors for pneumocystis pneumonia infection.
    Shah K; Queener S; Cody V; Pace J; Gangjee A
    Bioorg Med Chem Lett; 2019 Aug; 29(15):1874-1880. PubMed ID: 31176699
    [TBL] [Abstract][Full Text] [Related]  

  • 53. Purification and properties of recombinant Pneumocystis carinii dihydrofolate reductase.
    Sirawaraporn W; Edman JC; Santi DV
    Protein Expr Purif; 1991; 2(5-6):313-6. PubMed ID: 1821803
    [TBL] [Abstract][Full Text] [Related]  

  • 54. Structural studies on bioactive compounds. Part 36: design, synthesis and biological evaluation of pyrimethamine-based antifolates against Pneumocystis carinii.
    Chan DC; Laughton CA; Queener SF; Stevens MF
    Bioorg Med Chem; 2002 Sep; 10(9):3001-10. PubMed ID: 12110323
    [TBL] [Abstract][Full Text] [Related]  

  • 55. Structural studies on bioactive compounds. 28. Selective activity of triazenyl-substituted pyrimethamine derivatives against Pneumocystis carinii dihydrofolate reductase.
    Stevens MF; Phillip KS; Rathbone DL; O'Shea DM; Queener SF; Schwalbe CH; Lambert PA
    J Med Chem; 1997 Jun; 40(12):1886-93. PubMed ID: 9191966
    [TBL] [Abstract][Full Text] [Related]  

  • 56. Prediction of dihydrofolate reductase inhibition and selectivity using computational neural networks and linear discriminant analysis.
    Mattioni BE; Jurs PC
    J Mol Graph Model; 2003 Mar; 21(5):391-419. PubMed ID: 12543137
    [TBL] [Abstract][Full Text] [Related]  

  • 57. 6-substituted 2,4-diamino-5-methylpyrido[2,3-d]pyrimidines as inhibitors of dihydrofolate reductases from Pneumocystis carinii and Toxoplasma gondii and as antitumor agents.
    Gangjee A; Vasudevan A; Queener SF; Kisliuk RL
    J Med Chem; 1995 May; 38(10):1778-85. PubMed ID: 7752201
    [TBL] [Abstract][Full Text] [Related]  

  • 58. Activity of lipid-soluble inhibitors of dihydrofolate reductase against Pneumocystis carinii in culture and in a rat model of infection.
    Queener SF; Bartlett MS; Jay MA; Durkin MM; Smith JW
    Antimicrob Agents Chemother; 1987 Sep; 31(9):1323-7. PubMed ID: 2445281
    [TBL] [Abstract][Full Text] [Related]  

  • 59. The structure of Pneumocystis carinii dihydrofolate reductase to 1.9 A resolution.
    Champness JN; Achari A; Ballantine SP; Bryant PK; Delves CJ; Stammers DK
    Structure; 1994 Oct; 2(10):915-24. PubMed ID: 7866743
    [TBL] [Abstract][Full Text] [Related]  

  • 60. Pneumocystis carinii dihydrofolate reductase used to screen potential antipneumocystis drugs.
    Broughton MC; Queener SF
    Antimicrob Agents Chemother; 1991 Jul; 35(7):1348-55. PubMed ID: 1929292
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 7.