BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

117 related articles for article (PubMed ID: 11453736)

  • 1. Resolution of alpha-hydroxytamoxifen; R-isomer forms more DNA adducts in rat liver cells.
    Osborne MR; Hewer A; Phillips DH
    Chem Res Toxicol; 2001 Jul; 14(7):888-93. PubMed ID: 11453736
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Stereoselective metabolic activation of alpha-hydroxy-N-desmethyltamoxifen: the R-isomer forms more DNA adducts in rat liver cells.
    Osborne MR; Hewer A; Phillips DH
    Chem Res Toxicol; 2004 May; 17(5):697-701. PubMed ID: 15144227
    [TBL] [Abstract][Full Text] [Related]  

  • 3. 4-Hydroxytamoxifen gives DNA adducts by chemical activation, but not in rat liver cells.
    Osborne MR; Davis W; Hewer AJ; Hardcastle IR; Phillips DH
    Chem Res Toxicol; 1999 Feb; 12(2):151-8. PubMed ID: 10027792
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Determination of DNA damage in F344 rats induced by geometric isomers of tamoxifen and analogues.
    Brown K; Brown JE; Martin EA; Smith LL; White IN
    Chem Res Toxicol; 1998 May; 11(5):527-34. PubMed ID: 9585484
    [TBL] [Abstract][Full Text] [Related]  

  • 5. DNA adduct formation and mutant induction in Sprague-Dawley rats treated with tamoxifen and its derivatives.
    Gamboa da Costa G; McDaniel-Hamilton LP; Heflich RH; Marques MM; Beland FA
    Carcinogenesis; 2001 Aug; 22(8):1307-15. PubMed ID: 11470763
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Major inter-species differences in the rates of O-sulphonation and O-glucuronylation of alpha-hydroxytamoxifen in vitro: a metabolic disparity protecting human liver from the formation of tamoxifen-DNA adducts.
    Boocock DJ; Maggs JL; Brown K; White IN; Park BK
    Carcinogenesis; 2000 Oct; 21(10):1851-8. PubMed ID: 11023543
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Activation of tamoxifen and its metabolite alpha-hydroxytamoxifen to DNA-binding products: comparisons between human, rat and mouse hepatocytes.
    Phillips DH; Carmichael PL; Hewer A; Cole KJ; Hardcastle IR; Poon GK; Keogh A; Strain AJ
    Carcinogenesis; 1996 Jan; 17(1):89-94. PubMed ID: 8565142
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Tamoxifen metabolism in rat liver microsomes: identification of a dimeric metabolite derived from free radical intermediates by liquid chromatography/mass spectrometry.
    Jones RM; Yuan ZX; Lim CK
    Rapid Commun Mass Spectrom; 1999; 13(4):211-5. PubMed ID: 10097399
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis and DNA reactivity of alpha-hydroxylated metabolites of nonsteroidal antiestrogens.
    Hardcastle IR; Horton MN; Osborne MR; Hewer A; Jarman M; Phillips DH
    Chem Res Toxicol; 1998 Apr; 11(4):369-74. PubMed ID: 9548808
    [TBL] [Abstract][Full Text] [Related]  

  • 10. alpha-Hydroxytamoxifen, a metabolite of tamoxifen with exceptionally high DNA-binding activity in rat hepatocytes.
    Phillips DH; Carmichael PL; Hewer A; Cole KJ; Poon GK
    Cancer Res; 1994 Nov; 54(21):5518-22. PubMed ID: 7923188
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Idoxifene derivatives are less reactive to DNA than tamoxifen derivatives, both chemically and in human and rat liver cells.
    Osborne MR; Hewer A; Davis W; Strain AJ; Keogh A; Hardcastle IR; Phillips DH
    Carcinogenesis; 1999 Feb; 20(2):293-7. PubMed ID: 10069467
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Tamoxifen metabolic activation: comparison of DNA adducts formed by microsomal and chemical activation of tamoxifen and 4-hydroxytamoxifen with DNA adducts formed in vivo.
    Moorthy B; Sriram P; Pathak DN; Bodell WJ; Randerath K
    Cancer Res; 1996 Jan; 56(1):53-7. PubMed ID: 8548775
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Preparation of oligodeoxynucleotides containing a diastereoisomer of alpha-(N(2)-2'-deoxyguanosinyl)tamoxifen by phosphoramidite chemical synthesis.
    Santosh Laxmi YR; Suzuki N; Dasaradhi L; Johnson F; Shibutani S
    Chem Res Toxicol; 2002 Feb; 15(2):218-25. PubMed ID: 11849048
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Organ specificity of DNA adduct formation by tamoxifen and alpha-hydroxytamoxifen in the rat: implications for understanding the mechanism(s) of tamoxifen carcinogenicity and for human risk assessment.
    Phillips DH; Hewer A; Osborne MR; Cole KJ; Churchill C; Arlt VM
    Mutagenesis; 2005 Jul; 20(4):297-303. PubMed ID: 15928012
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Studies on the stability of trans-alpha-acetoxytamoxifen in Sprague-Dawley female rat liver slices, homogenate and subcellular fractions including microsomes and mitochondria.
    Jordan CG; Brown K; Beedham C; Brown JE
    Int J Pharm; 1999 Jan; 177(2):259-70. PubMed ID: 10205619
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Comparison of the DNA adducts formed by tamoxifen and 4-hydroxytamoxifen in vivo.
    Beland FA; McDaniel LP; Marques MM
    Carcinogenesis; 1999 Mar; 20(3):471-7. PubMed ID: 10190564
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Evaluation of tamoxifen and alpha-hydroxytamoxifen 32P-post-labelled DNA adducts by the development of a novel automated on-line solid-phase extraction HPLC method.
    Martin EA; Heydon RT; Brown K; Brown JE; Lim CK; White IN; Smith LL
    Carcinogenesis; 1998 Jun; 19(6):1061-9. PubMed ID: 9667745
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Microsomal and peroxidase activation of 4-hydroxy-tamoxifen to form DNA adducts: comparison with DNA adducts formed in Sprague-Dawley rats treated with tamoxifen.
    Pathak DN; Pongracz K; Bodell WJ
    Carcinogenesis; 1995 Jan; 16(1):11-5. PubMed ID: 7834794
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Identification of the major tamoxifen-DNA adducts in rat liver by mass spectroscopy.
    Rajaniemi H; Rasanen I; Koivisto P; Peltonen K; Hemminki K
    Carcinogenesis; 1999 Feb; 20(2):305-9. PubMed ID: 10069469
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Alpha-hydroxytamoxifen is a substrate of hydroxysteroid (alcohol) sulfotransferase, resulting in tamoxifen DNA adducts.
    Shibutani S; Dasaradhi L; Terashima I; Banoglu E; Duffel MW
    Cancer Res; 1998 Feb; 58(4):647-53. PubMed ID: 9485016
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.