These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

107 related articles for article (PubMed ID: 11456831)

  • 1. Thiol-independent DNA alkylation by leinamycin.
    Breydo L; Zang H; Mitra K; Gates KS
    J Am Chem Soc; 2001 Mar; 123(9):2060-1. PubMed ID: 11456831
    [No Abstract]   [Full Text] [Related]  

  • 2. Thiol-independent DNA cleavage by a leinamycin degradation product.
    Asai A; Saito H; Saitoh Y
    Bioorg Med Chem; 1997 Apr; 5(4):723-9. PubMed ID: 9158871
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Mechanisms of DNA damage by leinamycin.
    Gates KS
    Chem Res Toxicol; 2000 Oct; 13(10):953-6. PubMed ID: 11080040
    [No Abstract]   [Full Text] [Related]  

  • 4. 1,2-Dithiolan-3-one 1-oxides: a class of thiol-activated DNA-cleaving agents that are structurally related to the natural product leinamycin.
    Behroozi SJ; Kim W; Dannaldson J; Gates KS
    Biochemistry; 1996 Feb; 35(6):1768-74. PubMed ID: 8639657
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Sequence specificity of DNA alkylation by the antitumor natural product leinamycin.
    Zang H; Gates KS
    Chem Res Toxicol; 2003 Dec; 16(12):1539-46. PubMed ID: 14680367
    [TBL] [Abstract][Full Text] [Related]  

  • 6. DNA alkylation by leinamycin can be triggered by cyanide and phosphines.
    Zang H; Breydo L; Mitra K; Dannaldson J; Gates KS
    Bioorg Med Chem Lett; 2001 Jun; 11(12):1511-5. PubMed ID: 11412971
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Small molecules that mimic the thiol-triggered alkylating properties seen in the natural product leinamycin.
    Chatterji T; Kizil M; Keerthi K; Chowdhury G; Pospísil T; Gates KS
    J Am Chem Soc; 2003 Apr; 125(17):4996-7. PubMed ID: 12708847
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Activation of leinamycin by thiols: a theoretical study.
    Breydo L; Gates KS
    J Org Chem; 2002 Dec; 67(25):9054-60. PubMed ID: 12467428
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Entering the leinamycin rearrangement via 2-(trimethylsilyl)ethyl sulfoxides.
    Keerthi K; Gates KS
    Org Biomol Chem; 2007 May; 5(10):1595-600. PubMed ID: 17571189
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Thiol-dependent DNA cleavage by 3H-1,2-benzodithiol-3-one 1,1-dioxide.
    Breydo L; Gates KS
    Bioorg Med Chem Lett; 2000 May; 10(9):885-9. PubMed ID: 10853652
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Chemical properties of the leinamycin-guanine adduct in DNA.
    Nooner T; Dutta S; Gates KS
    Chem Res Toxicol; 2004 Jul; 17(7):942-9. PubMed ID: 15257620
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Two (E,E)- and (Z,E)-thiazol-5-ylpenta-2,4-dienones.
    Breydo L; Barnes CL; Gates KS
    Acta Crystallogr C; 2002 Aug; 58(Pt 8):o447-9. PubMed ID: 12154296
    [TBL] [Abstract][Full Text] [Related]  

  • 13. DNA strand scission by the novel antitumor antibiotic leinamycin.
    Hara M; Saitoh Y; Nakano H
    Biochemistry; 1990 Jun; 29(24):5676-81. PubMed ID: 2383554
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The macrocycle of leinamycin imparts hydrolytic stability to the thiol-sensing 1,2-dithiolan-3-one 1-oxide unit of the natural product.
    Sivaramakrishnan S; Breydo L; Sun D; Gates KS
    Bioorg Med Chem Lett; 2012 Jun; 22(11):3791-4. PubMed ID: 22560586
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Attractive through-space S-O interaction in the DNA-cleaving antitumor antibiotic leinamycin.
    Wu S; Greer A
    J Org Chem; 2000 Aug; 65(16):4883-7. PubMed ID: 10956467
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synthesis and antitumor activity of novel thioester derivatives of leinamycin.
    Kanda Y; Ashizawa T; Kakita S; Takahashi Y; Kono M; Yoshida M; Saitoh Y; Okabe M
    J Med Chem; 1999 Apr; 42(8):1330-2. PubMed ID: 10212117
    [No Abstract]   [Full Text] [Related]  

  • 17. Synthesis and characterization of a small analogue of the anticancer natural product leinamycin.
    Keerthi K; Rajapakse A; Sun D; Gates KS
    Bioorg Med Chem; 2013 Jan; 21(1):235-41. PubMed ID: 23168080
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Cellular response and molecular mechanism of antitumor activity by leinamycin in MiaPaCa human pancreatic cancer cells.
    Bassett S; Urrabaz R; Sun D
    Anticancer Drugs; 2004 Aug; 15(7):689-96. PubMed ID: 15269600
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Noncovalent DNA binding drives DNA alkylation by leinamycin: evidence that the Z,E-5-(thiazol-4-yl)-penta-2,4-dienone moiety of the natural product serves as an atypical DNA intercalator.
    Fekry MI; Szekely J; Dutta S; Breydo L; Zang H; Gates KS
    J Am Chem Soc; 2011 Nov; 133(44):17641-51. PubMed ID: 21954957
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Synthesis and cytotoxicity of leinamycin antibiotic analogues.
    Szilagyi A; Fenyvesi F; Majercsik O; Pelyvas IF; Bacskay I; Fehér P; Varadi J; Vecsernyés M; Herczegh P
    J Med Chem; 2006 Sep; 49(18):5626-30. PubMed ID: 16942037
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.