These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

105 related articles for article (PubMed ID: 11459639)

  • 1. Evaluation of amino acid-based linkers in potent macrocyclic inhibitors of farnesyl-protein transferase.
    Beshore DC; Bell IM; Dinsmore CJ; Homnick CF; Culberson JC; Robinson RG; Fernandes C; Walsh ES; Abrams MT; Bhimnathwala HG; Davide JP; Ellis-Hutchings MS; Huber HA; Koblan KS; Buser CA; Kohl NE; Lobell RB; Chen IW; McLoughlin DA; Olah TV; Graham SL; Hartman GD; Williams TM
    Bioorg Med Chem Lett; 2001 Jul; 11(14):1817-21. PubMed ID: 11459639
    [TBL] [Abstract][Full Text] [Related]  

  • 2. 3-Aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency.
    Bell IM; Gallicchio SN; Abrams M; Beese LS; Beshore DC; Bhimnathwala H; Bogusky MJ; Buser CA; Culberson JC; Davide J; Ellis-Hutchings M; Fernandes C; Gibbs JB; Graham SL; Hamilton KA; Hartman GD; Heimbrook DC; Homnick CF; Huber HE; Huff JR; Kassahun K; Koblan KS; Kohl NE; Lobell RB; Lynch JJ; Robinson R; Rodrigues AD; Taylor JS; Walsh ES; Williams TM; Zartman CB
    J Med Chem; 2002 Jun; 45(12):2388-409. PubMed ID: 12036349
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The synthesis and biological evaluation of a series of potent dual inhibitors of farnesyl and geranyl-Geranyl protein transferases.
    Tucker TJ; Abrams MT; Buser CA; Davide JP; Ellis-Hutchings M; Fernandes C; Gibbs JB; Graham SL; Hartman GD; Huber HE; Liu D; Lobell RB; Lumma WC; Robinson RG; Sisko JT; Smith AM
    Bioorg Med Chem Lett; 2002 Aug; 12(15):2027-30. PubMed ID: 12113834
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Potent and selective farnesyl transferase inhibitors.
    Millet R; Domarkas J; Houssin R; Gilleron P; Goossens JF; Chavatte P; Logé C; Pommery N; Pommery J; Hénichart JP
    J Med Chem; 2004 Dec; 47(27):6812-20. PubMed ID: 15615530
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Imidazole-containing diarylether and diarylsulfone inhibitors of farnesyl-protein transferase.
    Dinsmore CJ; Williams TM; O'Neill TJ; Liu D; Rands E; Culberson JC; Lobell RB; Koblan KS; Kohl NE; Gibbs JB; Oliff AI; Graham SL; Hartman GD
    Bioorg Med Chem Lett; 1999 Dec; 9(23):3301-6. PubMed ID: 10612589
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Design, synthesis, and pharmacological evaluation of new farnesyl protein transferase inhibitors.
    Houssin R; Pommery J; Salaün MC; Deweer S; Goossens JF; Chavatte P; Hénichart JP
    J Med Chem; 2002 Jan; 45(2):533-6. PubMed ID: 11784157
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Exploring the role of bromine at C(10) of (+)-4-[2-[4-(8-chloro-3,10-dibromo- 6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11(R)-yl)-1-piperidinyl]-2- oxoethyl]-1-piperidinecarboxamide (Sch-66336): the discovery of indolocycloheptapyridine inhibitors of farnesyl protein transferase.
    Taveras AG; Aki C; Chao J; Doll RJ; Lalwani T; Girijavallabhan V; Strickland CL; Windsor WT; Weber P; Hollinger F; Snow M; Patton R; Kirschmeier P; James L; Liu M; Nomeir A
    J Med Chem; 2002 Aug; 45(18):3854-64. PubMed ID: 12190309
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Diaryl ether inhibitors of farnesyl-protein transferase.
    Mactough SC; Desolms SJ; Shaw AW; Abrams MT; Ciccarone TM; Davide JP; Hamilton KA; Hutchinson JH; Koblan KS; Kohl NE; Lobell RB; Robinson RG; Graham SL
    Bioorg Med Chem Lett; 2001 May; 11(10):1257-60. PubMed ID: 11392531
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Non-thiol 3-aminomethylbenzamide inhibitors of farnesyl-protein transferase.
    Ciccarone TM; MacTough SC; Williams TM; Dinsmore CJ; O'Neill TJ; Shah D; Culberson JC; Koblan KS; Kohl NE; Gibbs JB; Oliff AI; Graham SL; Hartman GD
    Bioorg Med Chem Lett; 1999 Jul; 9(14):1991-6. PubMed ID: 10450968
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Bridgehead modification of trihalocycloheptabenzopyridine leads to a potent farnesyl protein transferase inhibitor with improved oral metabolic stability.
    Njoroge FG; Vibulbhan B; Shi X; Strickland C; Kirschmeier P; Bishop R; Nomeir A; Girijavallabhan V
    Bioorg Med Chem Lett; 2004 Dec; 14(23):5899-902. PubMed ID: 15501065
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Aryl tetrahydropyridine inhibitors of farnesyltransferase: bioavailable analogues with improved cellular potency.
    Gwaltney SL; O'Connor SJ; Nelson LT; Sullivan GM; Imade H; Wang W; Hasvold L; Li Q; Cohen J; Gu WZ; Tahir SK; Bauch J; Marsh K; Ng SC; Frost DJ; Zhang H; Muchmore S; Jakob CG; Stoll V; Hutchins C; Rosenberg SH; Sham HL
    Bioorg Med Chem Lett; 2003 Apr; 13(7):1363-6. PubMed ID: 12657283
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Substituted azoloquinolines and -quinazolines as new potent farnesyl protein transferase inhibitors.
    Angibaud P; Bourdrez X; End DW; Freyne E; Janicot M; Lezouret P; Ligny Y; Mannens G; Damsch S; Mevellec L; Meyer C; Muller P; Pilatte I; Poncelet V; Roux B; Smets G; Van Dun J; Van Remoortere P; Venet M; Wouters W
    Bioorg Med Chem Lett; 2003 Dec; 13(24):4365-9. PubMed ID: 14643327
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis of N,N'-disubstituted 3-aminobenzo[c] and [d]azepin-2-ones as potent and specific farnesyl transferase inhibitors.
    Le Diguarher T; Ortuno JC; Shanks D; Guilbaud N; Pierré A; Raimbaud E; Fauchère JL; Hickman JA; Tucker GC; Casara PJ
    Bioorg Med Chem Lett; 2004 Feb; 14(3):767-71. PubMed ID: 14741286
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Aromatic carboxylic acids as farnesyl surrogates in farnesylpyrophosphate-based farnesyltransferase inhibitors.
    Schlitzer M; Sattler I
    Bioorg Med Chem; 1999 Nov; 7(11):2391-5. PubMed ID: 10632048
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Prenyloxyphenylpropanoids as novel lead compounds for the selective inhibition of geranylgeranyl transferase I.
    Epifano F; Curini M; Genovese S; Blaskovich M; Hamilton A; Sebti SM
    Bioorg Med Chem Lett; 2007 May; 17(9):2639-42. PubMed ID: 17314046
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models.
    Lobell RB; Omer CA; Abrams MT; Bhimnathwala HG; Brucker MJ; Buser CA; Davide JP; deSolms SJ; Dinsmore CJ; Ellis-Hutchings MS; Kral AM; Liu D; Lumma WC; Machotka SV; Rands E; Williams TM; Graham SL; Hartman GD; Oliff AI; Heimbrook DC; Kohl NE
    Cancer Res; 2001 Dec; 61(24):8758-68. PubMed ID: 11751396
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Solid-phase synthesis of novel inhibitors of farnesyl transferase.
    Barber AM; Hardcastle IR; Rowlands MG; Nutley BP; Marriott JH; Jarman M
    Bioorg Med Chem Lett; 1999 Feb; 9(4):623-6. PubMed ID: 10098677
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Analogs of 4-(3-bromo-8-methyl-10-methoxy-6,11-dihydro-5H-benzo[5,6]-cyclo hepta[1,2-b]pyridin-11-yl)-1-(4-pyridinylacetyl)piperidine N-oxide as inhibitors of farnesyl protein transferase.
    Afonso A; Kelly J; Weinstein J; James L; Bishop WR
    Bioorg Med Chem Lett; 1999 Jul; 9(13):1875-80. PubMed ID: 10406658
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Potent, selective, and orally bioavailable tricyclic pyridyl acetamide N-oxide inhibitors of farnesyl protein transferase with enhanced in vivo antitumor activity.
    Njoroge FG; Vibulbhan B; Pinto P; Bishop WR; Bryant MS; Nomeir AA; Lin C; Liu M; Doll RJ; Girijavallabhan V; Ganguly AK
    J Med Chem; 1998 May; 41(10):1561-7. PubMed ID: 9572881
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Farnesyl-derived inhibitors of ras farnesyl transferase.
    Kang MS; Stemerick DM; Zwolshen JH; Harry BS; Sunkara PS; Harrison BL
    Biochem Biophys Res Commun; 1995 Dec; 217(1):245-9. PubMed ID: 8526918
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.