These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

154 related articles for article (PubMed ID: 11463854)

  • 1. A free carboxylate oxygen in the side chain of position 674 in transmembrane domain 7 is necessary for TSH receptor activation.
    Neumann S; Krause G; Chey S; Paschke R
    Mol Endocrinol; 2001 Aug; 15(8):1294-305. PubMed ID: 11463854
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Interactions between the extracellular domain and the extracellular loops as well as the 6th transmembrane domain are necessary for TSH receptor activation.
    Neumann S; Claus M; Paschke R
    Eur J Endocrinol; 2005 Apr; 152(4):625-34. PubMed ID: 15817920
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The hinge region of the TSH receptor stabilizes ligand binding and determines different signaling profiles of human and bovine TSH.
    Jaeschke H; Schaarschmidt J; Günther R; Mueller S
    Endocrinology; 2011 Oct; 152(10):3986-96. PubMed ID: 21846801
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Somatic mutations causing constitutive activity of the thyrotropin receptor are the major cause of hyperfunctioning thyroid adenomas: identification of additional mutations activating both the cyclic adenosine 3',5'-monophosphate and inositol phosphate-Ca2+ cascades.
    Parma J; Van Sande J; Swillens S; Tonacchera M; Dumont J; Vassart G
    Mol Endocrinol; 1995 Jun; 9(6):725-33. PubMed ID: 8592518
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Substitutions of different regions of the third cytoplasmic loop of the thyrotropin (TSH) receptor have selective effects on constitutive, TSH-, and TSH receptor autoantibody-stimulated phosphoinositide and 3',5'-cyclic adenosine monophosphate signal generation.
    Kosugi S; Okajima F; Ban T; Hidaka A; Shenker A; Kohn LD
    Mol Endocrinol; 1993 Aug; 7(8):1009-20. PubMed ID: 7901757
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Constitutive activation of cyclic AMP but not phosphatidylinositol signaling caused by four mutations in the 6th transmembrane helix of the human thyrotropin receptor.
    Kosugi S; Shenker A; Mori T
    FEBS Lett; 1994 Dec; 356(2-3):291-4. PubMed ID: 7805857
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Identification and functional characterization of two new somatic mutations causing constitutive activation of the thyrotropin receptor in hyperfunctioning autonomous adenomas of the thyroid.
    Paschke R; Tonacchera M; Van Sande J; Parma J; Vassart G
    J Clin Endocrinol Metab; 1994 Dec; 79(6):1785-9. PubMed ID: 7989485
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Characterization of a region of the lutropin receptor extracellular domain near transmembrane helix 1 that is important in ligand-mediated signaling.
    Alvarez CA; Narayan P; Huang J; Puett D
    Endocrinology; 1999 Apr; 140(4):1775-82. PubMed ID: 10098515
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Diversity and prevalence of somatic mutations in the thyrotropin receptor and Gs alpha genes as a cause of toxic thyroid adenomas.
    Parma J; Duprez L; Van Sande J; Hermans J; Rocmans P; Van Vliet G; Costagliola S; Rodien P; Dumont JE; Vassart G
    J Clin Endocrinol Metab; 1997 Aug; 82(8):2695-701. PubMed ID: 9253356
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The first activating TSH receptor mutation in transmembrane domain 1 identified in a family with nonautoimmune hyperthyroidism.
    Biebermann H; Schöneberg T; Hess C; Germak J; Gudermann T; Grüters A
    J Clin Endocrinol Metab; 2001 Sep; 86(9):4429-33. PubMed ID: 11549687
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Mutation of alanine 623 in the third cytoplasmic loop of the rat thyrotropin (TSH) receptor results in a loss in the phosphoinositide but not cAMP signal induced by TSH and receptor autoantibodies.
    Kosugi S; Okajima F; Ban T; Hidaka A; Shenker A; Kohn LD
    J Biol Chem; 1992 Dec; 267(34):24153-6. PubMed ID: 1332945
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Specific activation of the thyrotropin receptor by trypsin.
    Van Sande J; Massart C; Costagliola S; Allgeier A; Cetani F; Vassart G; Dumont JE
    Mol Cell Endocrinol; 1996 May; 119(2):161-8. PubMed ID: 8807635
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Functional role of transmembrane helix 7 in the activation of the heptahelical lutropin receptor.
    Angelova K; Narayan P; Simon JP; Puett D
    Mol Endocrinol; 2000 Apr; 14(4):459-71. PubMed ID: 10770485
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Proper targeting and activity of a nonfunctioning thyroid-stimulating hormone receptor (TSHr) combining an inactivating and activating TSHr mutation in one receptor.
    Agretti P; De Marco G; Collecchi P; Chiovato L; Vitti P; Pinchera A; Tonacchera M
    Eur J Biochem; 2003 Sep; 270(18):3839-47. PubMed ID: 12950268
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Structure-function relationships of two loss-of-function mutations of the thyrotropin receptor gene.
    Costagliola S; Sunthorntepvarakul T; Migeotte I; Van Sande J; Kajava AM; Refetoff S; Vassart G
    Thyroid; 1999 Oct; 9(10):995-1000. PubMed ID: 10560953
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Activation of the cAMP pathway by the TSH receptor involves switching of the ectodomain from a tethered inverse agonist to an agonist.
    Vlaeminck-Guillem V; Ho SC; Rodien P; Vassart G; Costagliola S
    Mol Endocrinol; 2002 Apr; 16(4):736-46. PubMed ID: 11923470
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The thyrotropin (TSH) receptor transmembrane domain mutation (Pro556-Leu) in the hypothyroid hyt/hyt mouse results in plasma membrane targeting but defective TSH binding.
    Gu WX; Du GG; Kopp P; Rentoumis A; Albanese C; Kohn LD; Madison LD; Jameson JL
    Endocrinology; 1995 Jul; 136(7):3146-53. PubMed ID: 7789342
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Phe576 plays an important role in the secondary structure and intracellular signaling of the human luteinizing hormone/chorionic gonadotropin receptor.
    Yano K; Kohn LD; Saji M; Okuno A; Cutler GB
    J Clin Endocrinol Metab; 1997 Aug; 82(8):2586-91. PubMed ID: 9253338
    [TBL] [Abstract][Full Text] [Related]  

  • 19. An activation switch in the rhodopsin family of G protein-coupled receptors: the thyrotropin receptor.
    Urizar E; Claeysen S; Deupí X; Govaerts C; Costagliola S; Vassart G; Pardo L
    J Biol Chem; 2005 Apr; 280(17):17135-41. PubMed ID: 15722344
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The middle portion in the second cytoplasmic loop of the thyrotropin receptor plays a crucial role in adenylate cyclase activation.
    Kosugi S; Kohn LD; Akamizu T; Mori T
    Mol Endocrinol; 1994 Apr; 8(4):498-509. PubMed ID: 7914349
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.