221 related articles for article (PubMed ID: 11472257)
1. Trypanothione as a target in the design of antitrypanosomal and antileishmanial agents.
Augustyns K; Amssoms K; Yamani A; Rajan PK; Haemers A
Curr Pharm Des; 2001 Aug; 7(12):1117-41. PubMed ID: 11472257
[TBL] [Abstract][Full Text] [Related]
2. Enzymes of the trypanothione metabolism as targets for antitrypanosomal drug development.
Schmidt A; Krauth-Siegel RL
Curr Top Med Chem; 2002 Nov; 2(11):1239-59. PubMed ID: 12171583
[TBL] [Abstract][Full Text] [Related]
3. Gamma-glutamylcysteine synthetase and tryparedoxin 1 exert high control on the antioxidant system in Trypanosoma cruzi contributing to drug resistance and infectivity.
González-Chávez Z; Vázquez C; Mejia-Tlachi M; Márquez-Dueñas C; Manning-Cela R; Encalada R; Rodríguez-Enríquez S; Michels PAM; Moreno-Sánchez R; Saavedra E
Redox Biol; 2019 Sep; 26():101231. PubMed ID: 31203195
[TBL] [Abstract][Full Text] [Related]
4. Targeting trypanothione metabolism in trypanosomatid human parasites.
Olin-Sandoval V; Moreno-Sánchez R; Saavedra E
Curr Drug Targets; 2010 Dec; 11(12):1614-30. PubMed ID: 20735352
[TBL] [Abstract][Full Text] [Related]
5. Phenotypic analysis of trypanothione synthetase knockdown in the African trypanosome.
Ariyanayagam MR; Oza SL; Guther ML; Fairlamb AH
Biochem J; 2005 Oct; 391(Pt 2):425-32. PubMed ID: 16008527
[TBL] [Abstract][Full Text] [Related]
6. Design, synthesis and biological evaluation of new potent 5-nitrofuryl derivatives as anti-Trypanosoma cruzi agents. Studies of trypanothione binding site of trypanothione reductase as target for rational design.
Aguirre G; Cabrera E; Cerecetto H; Di Maio R; González M; Seoane G; Duffaut A; Denicola A; Gil MJ; Martínez-Merino V
Eur J Med Chem; 2004 May; 39(5):421-31. PubMed ID: 15110968
[TBL] [Abstract][Full Text] [Related]
7. Drug target validation of the trypanothione pathway enzymes through metabolic modelling.
Olin-Sandoval V; González-Chávez Z; Berzunza-Cruz M; Martínez I; Jasso-Chávez R; Becker I; Espinoza B; Moreno-Sánchez R; Saavedra E
FEBS J; 2012 May; 279(10):1811-33. PubMed ID: 22394478
[TBL] [Abstract][Full Text] [Related]
8. Key proteins in the polyamine-trypanothione pathway as drug targets against Trypanosoma cruzi.
Maya JD; Salas CO; Aguilera-Venegas B; Diaz MV; López-Muñoz R
Curr Med Chem; 2014; 21(15):1757-71. PubMed ID: 24251576
[TBL] [Abstract][Full Text] [Related]
9. Effects of nifurtimox and benznidazole upon glutathione and trypanothione content in epimastigote, trypomastigote and amastigote forms of Trypanosoma cruzi.
Maya JD; Repetto Y; Agosín M; Ojeda JM; Tellez R; Gaule C; Morello A
Mol Biochem Parasitol; 1997 May; 86(1):101-6. PubMed ID: 9178272
[No Abstract] [Full Text] [Related]
10. Targeting the polyamine biosynthetic enzymes: a promising approach to therapy of African sleeping sickness, Chagas' disease, and leishmaniasis.
Heby O; Persson L; Rentala M
Amino Acids; 2007 Aug; 33(2):359-66. PubMed ID: 17610127
[TBL] [Abstract][Full Text] [Related]
11. Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors.
Bond CS; Zhang Y; Berriman M; Cunningham ML; Fairlamb AH; Hunter WN
Structure; 1999 Jan; 7(1):81-9. PubMed ID: 10368274
[TBL] [Abstract][Full Text] [Related]
12. New trypanocidal hybrid compounds from the association of hydrazone moieties and benzofuroxan heterocycle.
Porcal W; Hernández P; Boiani L; Boiani M; Ferreira A; Chidichimo A; Cazzulo JJ; Olea-Azar C; González M; Cerecetto H
Bioorg Med Chem; 2008 Jul; 16(14):6995-7004. PubMed ID: 18547811
[TBL] [Abstract][Full Text] [Related]
13. Metabolism and functions of trypanothione in the Kinetoplastida.
Fairlamb AH; Cerami A
Annu Rev Microbiol; 1992; 46():695-729. PubMed ID: 1444271
[TBL] [Abstract][Full Text] [Related]
14. Glutathione and trypanothione in several strains of Trypanosoma cruzi: effect of drugs.
Repetto Y; Opazo E; Maya JD; Agosin M; Morello A
Comp Biochem Physiol B Biochem Mol Biol; 1996 Oct; 115(2):281-5. PubMed ID: 8939007
[TBL] [Abstract][Full Text] [Related]
15. A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
Oza SL; Tetaud E; Ariyanayagam MR; Warnon SS; Fairlamb AH
J Biol Chem; 2002 Sep; 277(39):35853-61. PubMed ID: 12121990
[TBL] [Abstract][Full Text] [Related]
16. The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
Krauth-Siegel RL; Meiering SK; Schmidt H
Biol Chem; 2003 Apr; 384(4):539-49. PubMed ID: 12751784
[TBL] [Abstract][Full Text] [Related]
17. Targeting Trypanothione Metabolism in Trypanosomatids.
González-Montero MC; Andrés-Rodríguez J; García-Fernández N; Pérez-Pertejo Y; Reguera RM; Balaña-Fouce R; García-Estrada C
Molecules; 2024 May; 29(10):. PubMed ID: 38792079
[TBL] [Abstract][Full Text] [Related]
18. Buthionine sulfoximine is a multitarget inhibitor of trypanothione synthesis in Trypanosoma cruzi.
Vázquez C; Mejia-Tlachi M; González-Chávez Z; Silva A; Rodríguez-Zavala JS; Moreno-Sánchez R; Saavedra E
FEBS Lett; 2017 Dec; 591(23):3881-3894. PubMed ID: 29127710
[TBL] [Abstract][Full Text] [Related]
19. Phenothiazine inhibitors of trypanothione reductase as potential antitrypanosomal and antileishmanial drugs.
Chan C; Yin H; Garforth J; McKie JH; Jaouhari R; Speers P; Douglas KT; Rock PJ; Yardley V; Croft SL; Fairlamb AH
J Med Chem; 1998 Jan; 41(2):148-56. PubMed ID: 9457238
[TBL] [Abstract][Full Text] [Related]
20. Synthesis and evaluation of substrate analogue inhibitors of trypanothione reductase.
Duyzend MH; Clark CT; Simmons SL; Johnson WB; Larson AM; Leconte AM; Wills AW; Ginder-Vogel M; Wilhelm AK; Czechowicz JA; Alberg DG
J Enzyme Inhib Med Chem; 2012 Dec; 27(6):784-94. PubMed ID: 22085139
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
