Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

488 related articles for article (PubMed ID: 11479224)

  • 1. Abrogation of the Chk1-mediated G(2) checkpoint pathway potentiates temozolomide-induced toxicity in a p53-independent manner in human glioblastoma cells.
    Hirose Y; Berger MS; Pieper RO
    Cancer Res; 2001 Aug; 61(15):5843-9. PubMed ID: 11479224
    [TBL] [Abstract][Full Text] [Related]  

  • 2. p53 effects both the duration of G2/M arrest and the fate of temozolomide-treated human glioblastoma cells.
    Hirose Y; Berger MS; Pieper RO
    Cancer Res; 2001 Mar; 61(5):1957-63. PubMed ID: 11280752
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Cooperative function of Chk1 and p38 pathways in activating G2 arrest following exposure to temozolomide.
    Hirose Y; Katayama M; Berger MS; Pieper RO
    J Neurosurg; 2004 Jun; 100(6):1060-5. PubMed ID: 15200121
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Delayed repletion of O6-methylguanine-DNA methyltransferase resulting in failure to protect the human glioblastoma cell line SF767 from temozolomide-induced cytotoxicity.
    Hirose Y; Kreklau EL; Erickson LC; Berger MS; Pieper RO
    J Neurosurg; 2003 Mar; 98(3):591-8. PubMed ID: 12650433
    [TBL] [Abstract][Full Text] [Related]  

  • 5. DNA damage induced by temozolomide signals to both ATM and ATR: role of the mismatch repair system.
    Caporali S; Falcinelli S; Starace G; Russo MT; Bonmassar E; Jiricny J; D'Atri S
    Mol Pharmacol; 2004 Sep; 66(3):478-91. PubMed ID: 15322239
    [TBL] [Abstract][Full Text] [Related]  

  • 6. UCN-01 inhibits p53 up-regulation and abrogates gamma-radiation-induced G(2)-M checkpoint independently of p53 by targeting both of the checkpoint kinases, Chk2 and Chk1.
    Yu Q; La Rose J; Zhang H; Takemura H; Kohn KW; Pommier Y
    Cancer Res; 2002 Oct; 62(20):5743-8. PubMed ID: 12384533
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Poly(ADP-ribose) polymerase inhibitor increases growth inhibition and reduces G(2)/M cell accumulation induced by temozolomide in malignant glioma cells.
    Tentori L; Portarena I; Torino F; Scerrati M; Navarra P; Graziani G
    Glia; 2002 Oct; 40(1):44-54. PubMed ID: 12237842
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Akt activation suppresses Chk2-mediated, methylating agent-induced G2 arrest and protects from temozolomide-induced mitotic catastrophe and cellular senescence.
    Hirose Y; Katayama M; Mirzoeva OK; Berger MS; Pieper RO
    Cancer Res; 2005 Jun; 65(11):4861-9. PubMed ID: 15930307
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Potentiation of cytotoxicity of topoisomerase i poison by concurrent and sequential treatment with the checkpoint inhibitor UCN-01 involves disparate mechanisms resulting in either p53-independent clonogenic suppression or p53-dependent mitotic catastrophe.
    Tse AN; Schwartz GK
    Cancer Res; 2004 Sep; 64(18):6635-44. PubMed ID: 15374978
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Inhibition of c-Jun N-terminal kinase enhances temozolomide-induced cytotoxicity in human glioma cells.
    Ohba S; Hirose Y; Kawase T; Sano H
    J Neurooncol; 2009 Dec; 95(3):307-316. PubMed ID: 19517066
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Resveratrol abrogates the temozolomide-induced G2 arrest leading to mitotic catastrophe and reinforces the temozolomide-induced senescence in glioma cells.
    Filippi-Chiela EC; Thomé MP; Bueno e Silva MM; Pelegrini AL; Ledur PF; Garicochea B; Zamin LL; Lenz G
    BMC Cancer; 2013 Mar; 13():147. PubMed ID: 23522185
    [TBL] [Abstract][Full Text] [Related]  

  • 12. UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53.
    Wang Q; Fan S; Eastman A; Worland PJ; Sausville EA; O'Connor PM
    J Natl Cancer Inst; 1996 Jul; 88(14):956-65. PubMed ID: 8667426
    [TBL] [Abstract][Full Text] [Related]  

  • 13. p53-dependent Chk1 phosphorylation is required for maintenance of prolonged G2 Arrest.
    Wang XQ; Stanbridge EJ; Lao X; Cai Q; Fan ST; Redpath JL
    Radiat Res; 2007 Dec; 168(6):706-15. PubMed ID: 18088187
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Cadmium-induced DNA damage triggers G(2)/M arrest via chk1/2 and cdc2 in p53-deficient kidney proximal tubule cells.
    Bork U; Lee WK; Kuchler A; Dittmar T; Thévenod F
    Am J Physiol Renal Physiol; 2010 Feb; 298(2):F255-65. PubMed ID: 19923412
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The Cdk inhibitor flavopiridol enhances temozolomide-induced cytotoxicity in human glioma cells.
    Hayashi T; Adachi K; Ohba S; Hirose Y
    J Neurooncol; 2013 Nov; 115(2):169-78. PubMed ID: 23943501
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Cytotoxic effects of temozolomide and radiation are additive- and schedule-dependent.
    Chalmers AJ; Ruff EM; Martindale C; Lovegrove N; Short SC
    Int J Radiat Oncol Biol Phys; 2009 Dec; 75(5):1511-9. PubMed ID: 19931733
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Mechanisms of mitotic cell death induced by chemotherapy-mediated G2 checkpoint abrogation.
    Vogel C; Hager C; Bastians H
    Cancer Res; 2007 Jan; 67(1):339-45. PubMed ID: 17210716
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Abrogation of Chk1-mediated S/G2 checkpoint by UCN-01 enhances ara-C-induced cytotoxicity in human colon cancer cells.
    Shao RG; Cao CX; Pommier Y
    Acta Pharmacol Sin; 2004 Jun; 25(6):756-62. PubMed ID: 15169628
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Knockdown of Chk1 sensitizes human colon carcinoma HCT116 cells in a p53-dependent manner to lidamycin through abrogation of a G2/M checkpoint and induction of apoptosis.
    Pan Y; Ren KH; He HW; Shao RG
    Cancer Biol Ther; 2009 Aug; 8(16):1559-66. PubMed ID: 19502782
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01.
    Graves PR; Yu L; Schwarz JK; Gales J; Sausville EA; O'Connor PM; Piwnica-Worms H
    J Biol Chem; 2000 Feb; 275(8):5600-5. PubMed ID: 10681541
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 25.