BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

302 related articles for article (PubMed ID: 11483961)

  • 1. Nicastrin binds to membrane-tethered Notch.
    Chen F; Yu G; Arawaka S; Nishimura M; Kawarai T; Yu H; Tandon A; Supala A; Song YQ; Rogaeva E; Milman P; Sato C; Yu C; Janus C; Lee J; Song L; Zhang L; Fraser PE; St George-Hyslop PH
    Nat Cell Biol; 2001 Aug; 3(8):751-4. PubMed ID: 11483961
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane.
    Kaether C; Lammich S; Edbauer D; Ertl M; Rietdorf J; Capell A; Steiner H; Haass C
    J Cell Biol; 2002 Aug; 158(3):551-61. PubMed ID: 12147673
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing.
    Yu G; Nishimura M; Arawaka S; Levitan D; Zhang L; Tandon A; Song YQ; Rogaeva E; Chen F; Kawarai T; Supala A; Levesque L; Yu H; Yang DS; Holmes E; Milman P; Liang Y; Zhang DM; Xu DH; Sato C; Rogaev E; Smith M; Janus C; Zhang Y; Aebersold R; Farrer LS; Sorbi S; Bruni A; Fraser P; St George-Hyslop P
    Nature; 2000 Sep; 407(6800):48-54. PubMed ID: 10993067
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Gamma-secretase-like cleavages of Notch and beta APP are mutually exclusive in human cells.
    Petit A; St George-Hyslop P; Fraser P; Checler F
    Biochem Biophys Res Commun; 2002 Feb; 290(5):1408-10. PubMed ID: 11820778
    [TBL] [Abstract][Full Text] [Related]  

  • 5. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.
    De Strooper B; Annaert W; Cupers P; Saftig P; Craessaerts K; Mumm JS; Schroeter EH; Schrijvers V; Wolfe MS; Ray WJ; Goate A; Kopan R
    Nature; 1999 Apr; 398(6727):518-22. PubMed ID: 10206645
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Beta-amyloid secretases and beta-amloid degrading enzyme expression in lens.
    Li G; Percontino L; Sun Q; Qazi AS; Frederikse PH
    Mol Vis; 2003 May; 9():179-83. PubMed ID: 12740567
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Excess of nicastrin in brain results in heterozygosity having no effect on endogenous APP processing and amyloid peptide levels in vivo.
    Brijbassi S; Amtul Z; Newbigging S; Westaway D; St George-Hyslop P; Rozmahel RF
    Neurobiol Dis; 2007 Feb; 25(2):291-6. PubMed ID: 17071095
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Nicastrin functions as a gamma-secretase-substrate receptor.
    Shah S; Lee SF; Tabuchi K; Hao YH; Yu C; LaPlant Q; Ball H; Dann CE; Südhof T; Yu G
    Cell; 2005 Aug; 122(3):435-47. PubMed ID: 16096062
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Catalytic site-directed gamma-secretase complex inhibitors do not discriminate pharmacologically between Notch S3 and beta-APP cleavages.
    Lewis HD; Pérez Revuelta BI; Nadin A; Neduvelil JG; Harrison T; Pollack SJ; Shearman MS
    Biochemistry; 2003 Jun; 42(24):7580-6. PubMed ID: 12809514
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.
    Bentahir M; Nyabi O; Verhamme J; Tolia A; Horré K; Wiltfang J; Esselmann H; De Strooper B
    J Neurochem; 2006 Feb; 96(3):732-42. PubMed ID: 16405513
    [TBL] [Abstract][Full Text] [Related]  

  • 11. APPepsilon, the epsilon-secretase-derived N-terminal product of the beta-amyloid precursor protein, behaves as a type I protein and undergoes alpha-, beta-, and gamma-secretase cleavages.
    Lefranc-Jullien S; Sunyach C; Checler F
    J Neurochem; 2006 May; 97(3):807-17. PubMed ID: 16524370
    [TBL] [Abstract][Full Text] [Related]  

  • 12. CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production.
    Zhou S; Zhou H; Walian PJ; Jap BK
    Proc Natl Acad Sci U S A; 2005 May; 102(21):7499-504. PubMed ID: 15890777
    [TBL] [Abstract][Full Text] [Related]  

  • 13. New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage.
    Petit A; Bihel F; Alvès da Costa C; Pourquié O; Checler F; Kraus JL
    Nat Cell Biol; 2001 May; 3(5):507-11. PubMed ID: 11331880
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Aph-1 interacts at the cell surface with proteins in the active gamma-secretase complex and membrane-tethered Notch.
    Hansson EM; Strömberg K; Bergstedt S; Yu G; Näslund J; Lundkvist J; Lendahl U
    J Neurochem; 2005 Mar; 92(5):1010-20. PubMed ID: 15715652
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Processes of beta-amyloid and intracellular cytoplasmic domain generation by presenilin/gamma-secretase.
    Tagami S; Okochi M; Fukumori A; Jiang J; Yanagida K; Nakayama T; Morihara T; Tanaka T; Kudo T; Takeda M
    Neurodegener Dis; 2008; 5(3-4):160-2. PubMed ID: 18322378
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface.
    Kaether C; Schmitt S; Willem M; Haass C
    Traffic; 2006 Apr; 7(4):408-15. PubMed ID: 16536739
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The intramembrane cleavage site of the amyloid precursor protein depends on the length of its transmembrane domain.
    Lichtenthaler SF; Beher D; Grimm HS; Wang R; Shearman MS; Masters CL; Beyreuther K
    Proc Natl Acad Sci U S A; 2002 Feb; 99(3):1365-70. PubMed ID: 11805291
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s).
    Kimberly WT; Esler WP; Ye W; Ostaszewski BL; Gao J; Diehl T; Selkoe DJ; Wolfe MS
    Biochemistry; 2003 Jan; 42(1):137-44. PubMed ID: 12515548
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.
    Esler WP; Kimberly WT; Ostaszewski BL; Diehl TS; Moore CL; Tsai JY; Rahmati T; Xia W; Selkoe DJ; Wolfe MS
    Nat Cell Biol; 2000 Jul; 2(7):428-34. PubMed ID: 10878808
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment.
    Wiley JC; Hudson M; Kanning KC; Schecterson LC; Bothwell M
    J Neurochem; 2005 Sep; 94(5):1189-201. PubMed ID: 15992373
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.