136 related articles for article (PubMed ID: 11485982)
1. CREating a SCAP-less liver keeps SREBPs pinned in the ER membrane and prevents increased lipid synthesis in response to low cholesterol and high insulin.
Osborne TF
Genes Dev; 2001 Aug; 15(15):1873-8. PubMed ID: 11485982
[No Abstract] [Full Text] [Related]
2. Molecular regulation of SREBP function: the Insig-SCAP connection and isoform-specific modulation of lipid synthesis.
McPherson R; Gauthier A
Biochem Cell Biol; 2004 Feb; 82(1):201-11. PubMed ID: 15052338
[TBL] [Abstract][Full Text] [Related]
3. SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation.
Matsuda M; Korn BS; Hammer RE; Moon YA; Komuro R; Horton JD; Goldstein JL; Brown MS; Shimomura I
Genes Dev; 2001 May; 15(10):1206-16. PubMed ID: 11358865
[TBL] [Abstract][Full Text] [Related]
4. Role for sterol regulatory element-binding protein in activation of endothelial cells by phospholipid oxidation products.
Yeh M; Cole AL; Choi J; Liu Y; Tulchinsky D; Qiao JH; Fishbein MC; Dooley AN; Hovnanian T; Mouilleseaux K; Vora DK; Yang WP; Gargalovic P; Kirchgessner T; Shyy JY; Berliner JA
Circ Res; 2004 Oct; 95(8):780-8. PubMed ID: 15388640
[TBL] [Abstract][Full Text] [Related]
5. SREBP transcription factors: master regulators of lipid homeostasis.
Eberlé D; Hegarty B; Bossard P; Ferré P; Foufelle F
Biochimie; 2004 Nov; 86(11):839-48. PubMed ID: 15589694
[TBL] [Abstract][Full Text] [Related]
6. [SCAP: a polytopic membrane protein that modulates the sterol regulated cleavage of SREBPs].
Sakai J
Nihon Rinsho; 2001 Feb; 59 Suppl 2():270-6. PubMed ID: 11351587
[No Abstract] [Full Text] [Related]
7. [Mechanism of action of sterol regulatory element binding proteins (SREBPs) in cholesterol and fatty-acid biosynthesis].
Manzano León N; Torres N; Tovar AR
Rev Invest Clin; 2002; 54(2):145-53. PubMed ID: 12053813
[TBL] [Abstract][Full Text] [Related]
8. Cell biology. Fats, flies, and palmitate.
Nohturfft A; Losick R
Science; 2002 May; 296(5569):857-8. PubMed ID: 11988558
[No Abstract] [Full Text] [Related]
9. SREBPs suppress IRS-2-mediated insulin signalling in the liver.
Ide T; Shimano H; Yahagi N; Matsuzaka T; Nakakuki M; Yamamoto T; Nakagawa Y; Takahashi A; Suzuki H; Sone H; Toyoshima H; Fukamizu A; Yamada N
Nat Cell Biol; 2004 Apr; 6(4):351-7. PubMed ID: 15048126
[TBL] [Abstract][Full Text] [Related]
10. Rho-ROCK-LIMK-cofilin pathway regulates shear stress activation of sterol regulatory element binding proteins.
Lin T; Zeng L; Liu Y; DeFea K; Schwartz MA; Chien S; Shyy JY
Circ Res; 2003 Jun; 92(12):1296-304. PubMed ID: 12775580
[TBL] [Abstract][Full Text] [Related]
11. Insig: a significant integrator of nutrient and hormonal signals.
Attie AD
J Clin Invest; 2004 Apr; 113(8):1112-4. PubMed ID: 15085189
[TBL] [Abstract][Full Text] [Related]
12. Overexpression of membrane domain of SCAP prevents sterols from inhibiting SCAP.SREBP exit from endoplasmic reticulum.
Yang T; Goldstein JL; Brown MS
J Biol Chem; 2000 Sep; 275(38):29881-6. PubMed ID: 10896675
[TBL] [Abstract][Full Text] [Related]
13. Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis.
Engelking LJ; Kuriyama H; Hammer RE; Horton JD; Brown MS; Goldstein JL; Liang G
J Clin Invest; 2004 Apr; 113(8):1168-75. PubMed ID: 15085196
[TBL] [Abstract][Full Text] [Related]
14. The SREBP pathway--insights from Insigs and insects.
Rawson RB
Nat Rev Mol Cell Biol; 2003 Aug; 4(8):631-40. PubMed ID: 12923525
[TBL] [Abstract][Full Text] [Related]
15. [Depletion of cholesterol for signal transduction from endoplasmic reticulum to the cell nucleus--the proteolytic cleavage of transcription factors from the ER membranes].
Wieczorek B; Gniot-Szulzycka J
Postepy Biochem; 2002; 48(3):200-7. PubMed ID: 12625248
[No Abstract] [Full Text] [Related]
16. SCAP ligands are potent new lipid-lowering drugs.
Grand-Perret T; Bouillot A; Perrot A; Commans S; Walker M; Issandou M
Nat Med; 2001 Dec; 7(12):1332-8. PubMed ID: 11726974
[TBL] [Abstract][Full Text] [Related]
17. Isolation and radiation hybrid mapping of a highly polymorphic CA repeat sequence at the SREBP cleavage-activating protein (SCAP) locus.
Nakajima T; Ota N; Kodama T; Emi M
J Hum Genet; 1999; 44(5):350-1. PubMed ID: 10496082
[TBL] [Abstract][Full Text] [Related]
18. Cell biology: sterol sensor comes up for air.
Garza RM; Hampton RY
Nature; 2005 May; 435(7038):37-8. PubMed ID: 15875007
[No Abstract] [Full Text] [Related]
19. Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER.
Yang T; Espenshade PJ; Wright ME; Yabe D; Gong Y; Aebersold R; Goldstein JL; Brown MS
Cell; 2002 Aug; 110(4):489-500. PubMed ID: 12202038
[TBL] [Abstract][Full Text] [Related]
20. Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and Insigs.
Adams CM; Reitz J; De Brabander JK; Feramisco JD; Li L; Brown MS; Goldstein JL
J Biol Chem; 2004 Dec; 279(50):52772-80. PubMed ID: 15452130
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]