BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

289 related articles for article (PubMed ID: 11487279)

  • 1. The ability to accumulate deoxyuridine triphosphate and cellular response to thymidylate synthase (TS) inhibition.
    Webley SD; Welsh SJ; Jackman AL; Aherne GW
    Br J Cancer; 2001 Aug; 85(3):446-52. PubMed ID: 11487279
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Deoxyuridine triphosphatase (dUTPase) expression and sensitivity to the thymidylate synthase (TS) inhibitor ZD9331.
    Webley SD; Hardcastle A; Ladner RD; Jackman AL; Aherne GW
    Br J Cancer; 2000 Sep; 83(6):792-9. PubMed ID: 10952785
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Mechanism of cell death following thymidylate synthase inhibition: 2'-deoxyuridine-5'-triphosphate accumulation, DNA damage, and growth inhibition following exposure to CB3717 and dipyridamole.
    Curtin NJ; Harris AL; Aherne GW
    Cancer Res; 1991 May; 51(9):2346-52. PubMed ID: 2015598
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Small interfering RNA-mediated suppression of dUTPase sensitizes cancer cell lines to thymidylate synthase inhibition.
    Koehler SE; Ladner RD
    Mol Pharmacol; 2004 Sep; 66(3):620-6. PubMed ID: 15322254
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Determinants of cytotoxicity with prolonged exposure to fluorouracil in human colon cancer cells.
    Ren Q; Van Groeningen CJ; Hardcastle A; Aherne GW; Geoffroy F; Allegra CJ; Johnston PG; Grem JL
    Oncol Res; 1997; 9(2):77-88. PubMed ID: 9167189
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Expression of uracil DNA glycosylase (UDG) does not affect cellular sensitivity to thymidylate synthase (TS) inhibition.
    Welsh SJ; Hobbs S; Aherne GW
    Eur J Cancer; 2003 Feb; 39(3):378-87. PubMed ID: 12565992
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Resistance to fluorodeoxyuridine-induced DNA damage and cytotoxicity correlates with an elevation of deoxyuridine triphosphatase activity and failure to accumulate deoxyuridine triphosphate.
    Canman CE; Lawrence TS; Shewach DS; Tang HY; Maybaum J
    Cancer Res; 1993 Nov; 53(21):5219-24. PubMed ID: 8221659
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Structure/function analysis of a dUTPase: catalytic mechanism of a potential chemotherapeutic target.
    Harris JM; McIntosh EM; Muscat GE
    J Mol Biol; 1999 Apr; 288(2):275-87. PubMed ID: 10329142
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Serine/threonine protein phosphatase inhibition enhances the effect of thymidylate synthase inhibition.
    Sakoff JA; Howitt IJ; Ackland SP; McCluskey A
    Cancer Chemother Pharmacol; 2004 Mar; 53(3):225-32. PubMed ID: 14648018
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The role of dUTPase and uracil-DNA repair in cancer chemotherapy.
    Ladner RD
    Curr Protein Pept Sci; 2001 Dec; 2(4):361-70. PubMed ID: 12374095
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Inhibition of dUTPase induces synthetic lethality with thymidylate synthase-targeted therapies in non-small cell lung cancer.
    Wilson PM; LaBonte MJ; Lenz HJ; Mack PC; Ladner RD
    Mol Cancer Ther; 2012 Mar; 11(3):616-28. PubMed ID: 22172489
    [TBL] [Abstract][Full Text] [Related]  

  • 12. dUTPase and uracil-DNA glycosylase are central modulators of antifolate toxicity in Saccharomyces cerevisiae.
    Tinkelenberg BA; Hansbury MJ; Ladner RD
    Cancer Res; 2002 Sep; 62(17):4909-15. PubMed ID: 12208740
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Comparison of thymidylate synthase (TS) protein up-regulation after exposure to TS inhibitors in normal and tumor cell lines and tissues.
    Welsh SJ; Titley J; Brunton L; Valenti M; Monaghan P; Jackman AL; Aherne GW
    Clin Cancer Res; 2000 Jun; 6(6):2538-46. PubMed ID: 10873110
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Fluorodeoxyuridine modulates cellular expression of the DNA base excision repair enzyme uracil-DNA glycosylase.
    Fischer JA; Muller-Weeks S; Caradonna SJ
    Cancer Res; 2006 Sep; 66(17):8829-37. PubMed ID: 16951200
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Tumor growth inhibition in vivo and G2/M cell cycle arrest induced by antisense oligodeoxynucleotide targeting thymidylate synthase.
    Berg RW; Werner M; Ferguson PJ; Postenka C; Vincent M; Koropatnick DJ; Behrend E
    J Pharmacol Exp Ther; 2001 Aug; 298(2):477-84. PubMed ID: 11454908
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Cellular pharmacology and in vivo activity of a new anticancer agent, ZD9331: a water-soluble, nonpolyglutamatable, quinazoline-based inhibitor of thymidylate synthase.
    Jackman AL; Kimbell R; Aherne GW; Brunton L; Jansen G; Stephens TC; Smith MN; Wardleworth JM; Boyle FT
    Clin Cancer Res; 1997 Jun; 3(6):911-21. PubMed ID: 9815766
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Measurement of deoxyuridine triphosphate and thymidine triphosphate in the extracts of thymidylate synthase-inhibited cells using a modified DNA polymerase assay.
    Horowitz RW; Zhang H; Schwartz EL; Ladner RD; Wadler S
    Biochem Pharmacol; 1997 Sep; 54(5):635-8. PubMed ID: 9337081
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Mechanism and pharmacological specificity of dUTPase-mediated protection from DNA damage and cytotoxicity in human tumor cells.
    Parsels LA; Parsels JD; Wagner LM; Loney TL; Radany EH; Maybaum J
    Cancer Chemother Pharmacol; 1998; 42(5):357-62. PubMed ID: 9771948
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The transfection of thymidylate synthase antisense suppresses oncogenic properties of a human colon cancer cell line and augments the antitumor effect of fluorouracil.
    Matsuoka K; Tsukuda K; Suda M; Kobayashi K; Ota T; Okita A; Watanabe K; Suzuki E; Murakami M; Doihara H; Shimizu N
    Int J Oncol; 2004 Jan; 24(1):217-22. PubMed ID: 14654960
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Depletion of dimeric all-alpha dUTPase induces DNA strand breaks and impairs cell cycle progression in Trypanosoma brucei.
    Castillo-Acosta VM; Estévez AM; Vidal AE; Ruiz-Perez LM; González-Pacanowska D
    Int J Biochem Cell Biol; 2008; 40(12):2901-13. PubMed ID: 18656547
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.