164 related articles for article (PubMed ID: 11501794)
1. Conformational analysis and pharmacophore design for selected 1-(2-pyrimidinyl)piperazine derivatives with sedative-hypnotic activity.
Bronowska A; Leś A; Mazgajska M; Chilmończyk Z
Acta Pol Pharm; 2001; 58(2):79-86. PubMed ID: 11501794
[TBL] [Abstract][Full Text] [Related]
2. Structure-activity relationship in a series of new 1-(2-pyrimidinyl)piperazine derivatives with hypnotic activity.
Chilmonczyk Z; Bogdal M; Mazgajska M; Cybulski J; Lewandowska U
Pol J Pharmacol; 1996; 48(4):431-40. PubMed ID: 9112684
[TBL] [Abstract][Full Text] [Related]
3. 2D conformationally sampled pharmacophore: a ligand-based pharmacophore to differentiate delta opioid agonists from antagonists.
Bernard D; Coop A; MacKerell AD
J Am Chem Soc; 2003 Mar; 125(10):3101-7. PubMed ID: 12617677
[TBL] [Abstract][Full Text] [Related]
4. Pharmacological properties and SAR of new 1,4-disubstituted piperazine derivatives with hypnotic-sedative activity.
Chilmonczyk Z; Mazgajska M; Iskra-Jopa J; Chojnacka-Wójcik E; Tatarczyńska E; Kłodziriska A; Nowak JZ
J Pharm Pharmacol; 2002 May; 54(5):689-98. PubMed ID: 12005364
[TBL] [Abstract][Full Text] [Related]
5. Genomic and functional conservation of sedative-hypnotic targets in the zebrafish.
Renier C; Faraco JH; Bourgin P; Motley T; Bonaventure P; Rosa F; Mignot E
Pharmacogenet Genomics; 2007 Apr; 17(4):237-53. PubMed ID: 17496723
[TBL] [Abstract][Full Text] [Related]
6. New arylpiperazine 5-HT(1A) receptor ligands containing the pyrimido[2,1-f]purine fragment: synthesis, in vitro, and in vivo pharmacological evaluation.
Jurczyk S; Kołaczkowski M; Maryniak E; Zajdel P; Pawłowski M; Tatarczyńska E; Kłodzińska A; Chojnacka-Wójcik E; Bojarski AJ; Charakchieva-Minol S; Duszyńska B; Nowak G; Maciag D
J Med Chem; 2004 May; 47(10):2659-66. PubMed ID: 15115407
[TBL] [Abstract][Full Text] [Related]
7. Design, synthesis and biological activity of acyl substituted 3-amino-5-methyl-1,4,5,7-tetrahydropyrazolo[3,4-b]pyridin-6-ones as potential hypnotic drugs.
Falcó JL; Lloveras M; Buira I; Teixidó J; Borrell JI; Méndez E; Terencio J; Palomer A; Guglietta A
Eur J Med Chem; 2005 Nov; 40(11):1179-87. PubMed ID: 16095764
[TBL] [Abstract][Full Text] [Related]
8. 1-Aryl-4-(4-succinimidobutyl)piperazines and their conformationally constrained analogues: synthesis, binding to serotonin (5-HT1A, 5-HT2A, 5-HT7), alpha1-adrenergic, and dopaminergic D2 receptors, and in vivo 5-HT1A functional characteristics.
Bojarski AJ; Paluchowska MH; Duszyńska B; Kłodzińska A; Tatarczyńska E; Chojnacka-Wójcik E
Bioorg Med Chem; 2005 Mar; 13(6):2293-303. PubMed ID: 15727878
[TBL] [Abstract][Full Text] [Related]
9. Generation of predictive pharmacophore models for CCR5 antagonists: study with piperidine- and piperazine-based compounds as a new class of HIV-1 entry inhibitors.
Debnath AK
J Med Chem; 2003 Oct; 46(21):4501-15. PubMed ID: 14521412
[TBL] [Abstract][Full Text] [Related]
10. Sedative and hypnotic activities of pyrimidine nucleoside derivatives.
Kimura T; Teraoka S; Kuze J; Watanabe K; Kondo S; Ho IK; Yamamoto I
Nucleic Acids Symp Ser; 1993; (29):51-2. PubMed ID: 8247791
[TBL] [Abstract][Full Text] [Related]
11. Anxiolytic activity of a novel potent serotonin 5-HT2C receptor antagonist FR260010: a comparison with diazepam and buspirone.
Harada K; Aota M; Inoue T; Matsuda R; Mihara T; Yamaji T; Ishibashi K; Matsuoka N
Eur J Pharmacol; 2006 Dec; 553(1-3):171-84. PubMed ID: 17074317
[TBL] [Abstract][Full Text] [Related]
12. GABAA receptor pharmacology of fluorinated derivatives of the novel sedative-hypnotic pyrazolopyrimidine indiplon.
Wegner F; Deuther-Conrad W; Scheunemann M; Brust P; Fischer S; Hiller A; Diekers M; Strecker K; Wohlfarth K; Allgaier C; Steinbach J; Hoepping A
Eur J Pharmacol; 2008 Feb; 580(1-2):1-11. PubMed ID: 18035350
[TBL] [Abstract][Full Text] [Related]
13. Design, synthesis, and pharmacological evaluation of new neuroactive pyrazolo[3,4-b]pyrrolo[3,4-d]pyridine derivatives with in vivo hypnotic and analgesic profile.
Menegatti R; Silva GM; Zapata-Sudo G; Raimundo JM; Sudo RT; Barreiro EJ; Fraga CA
Bioorg Med Chem; 2006 Feb; 14(3):632-40. PubMed ID: 16198114
[TBL] [Abstract][Full Text] [Related]
14. Novel N-substituted indol-3-ylglyoxylamides probing the LDi and L1/L2 lipophilic regions of the benzodiazepine receptor site in search for subtype-selective ligands.
Primofiore G; Taliani S; Da Settimo F; Marini AM; La Motta C; Simorini F; Patrizi MP; Sergianni V; Novellino E; Greco G; Cosimelli B; Calderone V; Montali M; Besnard F; Martini C
J Med Chem; 2007 Apr; 50(7):1627-34. PubMed ID: 17335185
[TBL] [Abstract][Full Text] [Related]
15. Structure-activity relationships of simplified resiniferatoxin analogues with potent VR1 agonism elucidates an active conformation of RTX for VR1 binding.
Lee J; Kim SY; Park S; Lim JO; Kim JM; Kang M; Lee J; Kang SU; Choi HK; Jin MK; Welter JD; Szabo T; Tran R; Pearce LV; Toth A; Blumberg PM
Bioorg Med Chem; 2004 Mar; 12(5):1055-69. PubMed ID: 14980619
[TBL] [Abstract][Full Text] [Related]
16. Synthesis and evaluation of 2,6-piperidinedione derivatives as potentially novel compounds with analgesic and other CNS activities.
El Batran SA; Osman AE; Ismail MM; El Sayed AM
Inflammopharmacology; 2006 Mar; 14(1-2):62-71. PubMed ID: 16835715
[TBL] [Abstract][Full Text] [Related]
17. Molecule-pharmacophore superpositioning and pattern matching in computational drug design.
Wolber G; Seidel T; Bendix F; Langer T
Drug Discov Today; 2008 Jan; 13(1-2):23-9. PubMed ID: 18190860
[TBL] [Abstract][Full Text] [Related]
18. Sedative-hypnotic profile of novel isatin ketals.
Zapata-Sudo G; Pontes LB; Gabriel D; Mendes TC; Ribeiro NM; Pinto AC; Trachez MM; Sudo RT
Pharmacol Biochem Behav; 2007 Apr; 86(4):678-85. PubMed ID: 17382995
[TBL] [Abstract][Full Text] [Related]
19. Interaction of cis-(6-benzhydrylpiperidin-3-yl)benzylamine analogues with monoamine transporters: structure-activity relationship study of structurally constrained 3,6-disubstituted piperidine analogues of (2,2-diphenylethyl)-[1-(4-fluorobenzyl)piperidin-4-ylmethyl]amine.
Kolhatkar RB; Ghorai SK; George C; Reith ME; Dutta AK
J Med Chem; 2003 May; 46(11):2205-15. PubMed ID: 12747792
[TBL] [Abstract][Full Text] [Related]
20. A self-organizing algorithm for molecular alignment and pharmacophore development.
Bandyopadhyay D; Agrafiotis DK
J Comput Chem; 2008 Apr; 29(6):965-82. PubMed ID: 17999384
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
