BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

669 related articles for article (PubMed ID: 11504942)

  • 1. HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation.
    Yu F; White SB; Zhao Q; Lee FS
    Proc Natl Acad Sci U S A; 2001 Aug; 98(17):9630-5. PubMed ID: 11504942
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Dynamic, site-specific interaction of hypoxia-inducible factor-1alpha with the von Hippel-Lindau tumor suppressor protein.
    Yu F; White SB; Zhao Q; Lee FS
    Cancer Res; 2001 May; 61(10):4136-42. PubMed ID: 11358837
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein.
    Tanimoto K; Makino Y; Pereira T; Poellinger L
    EMBO J; 2000 Aug; 19(16):4298-309. PubMed ID: 10944113
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.
    Jaakkola P; Mole DR; Tian YM; Wilson MI; Gielbert J; Gaskell SJ; von Kriegsheim A; Hebestreit HF; Mukherji M; Schofield CJ; Maxwell PH; Pugh CW; Ratcliffe PJ
    Science; 2001 Apr; 292(5516):468-72. PubMed ID: 11292861
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function.
    Krieg M; Haas R; Brauch H; Acker T; Flamme I; Plate KH
    Oncogene; 2000 Nov; 19(48):5435-43. PubMed ID: 11114720
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis.
    Maxwell PH; Wiesener MS; Chang GW; Clifford SC; Vaux EC; Cockman ME; Wykoff CC; Pugh CW; Maher ER; Ratcliffe PJ
    Nature; 1999 May; 399(6733):271-5. PubMed ID: 10353251
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Activation of hypoxia-induced transcription in normoxia.
    Hägg M; Wennström S
    Exp Cell Res; 2005 May; 306(1):180-91. PubMed ID: 15878343
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The pVHL-associated SCF ubiquitin ligase complex: molecular genetic analysis of elongin B and C, Rbx1 and HIF-1alpha in renal cell carcinoma.
    Clifford SC; Astuti D; Hooper L; Maxwell PH; Ratcliffe PJ; Maher ER
    Oncogene; 2001 Aug; 20(36):5067-74. PubMed ID: 11526493
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-alpha-prolyl-4-hydroxylases.
    Marxsen JH; Stengel P; Doege K; Heikkinen P; Jokilehto T; Wagner T; Jelkmann W; Jaakkola P; Metzen E
    Biochem J; 2004 Aug; 381(Pt 3):761-7. PubMed ID: 15104534
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Effects of ras and von Hippel-Lindau (VHL) gene mutations on hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, and vascular endothelial growth factor expression and their regulation by the phosphatidylinositol 3'-kinase/Akt signaling pathway.
    Blancher C; Moore JW; Robertson N; Harris AL
    Cancer Res; 2001 Oct; 61(19):7349-55. PubMed ID: 11585776
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Identification of residues critical for regulation of protein stability and the transactivation function of the hypoxia-inducible factor-1alpha by the von Hippel-Lindau tumor suppressor gene product.
    Pereira T; Zheng X; Ruas JL; Tanimoto K; Poellinger L
    J Biol Chem; 2003 Feb; 278(9):6816-23. PubMed ID: 12468553
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Cobalt inhibits the interaction between hypoxia-inducible factor-alpha and von Hippel-Lindau protein by direct binding to hypoxia-inducible factor-alpha.
    Yuan Y; Hilliard G; Ferguson T; Millhorn DE
    J Biol Chem; 2003 May; 278(18):15911-6. PubMed ID: 12606543
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Constitutive activation of hypoxia-inducible genes related to overexpression of hypoxia-inducible factor-1alpha in clear cell renal carcinomas.
    Wiesener MS; Münchenhagen PM; Berger I; Morgan NV; Roigas J; Schwiertz A; Jürgensen JS; Gruber G; Maxwell PH; Löning SA; Frei U; Maher ER; Gröne HJ; Eckardt KU
    Cancer Res; 2001 Jul; 61(13):5215-22. PubMed ID: 11431362
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Regulation of HIF by the von Hippel-Lindau tumour suppressor: implications for cellular oxygen sensing.
    Mole DR; Maxwell PH; Pugh CW; Ratcliffe PJ
    IUBMB Life; 2001 Jul; 52(1-2):43-7. PubMed ID: 11795592
    [TBL] [Abstract][Full Text] [Related]  

  • 15. FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity.
    Mahon PC; Hirota K; Semenza GL
    Genes Dev; 2001 Oct; 15(20):2675-86. PubMed ID: 11641274
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Hypoxia up-regulates prolyl hydroxylase activity: a feedback mechanism that limits HIF-1 responses during reoxygenation.
    D'Angelo G; Duplan E; Boyer N; Vigne P; Frelin C
    J Biol Chem; 2003 Oct; 278(40):38183-7. PubMed ID: 12876291
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation.
    Masson N; Willam C; Maxwell PH; Pugh CW; Ratcliffe PJ
    EMBO J; 2001 Sep; 20(18):5197-206. PubMed ID: 11566883
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Expression of HIF-1 and ubiquitin in conventional renal cell carcinoma: relationship to mutations of the von Hippel-Lindau tumor suppressor gene.
    Hughson MD; He Z; Liu S; Coleman J; Shingleton WB
    Cancer Genet Cytogenet; 2003 Jun; 143(2):145-53. PubMed ID: 12781449
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The VHL protein recruits a novel KRAB-A domain protein to repress HIF-1alpha transcriptional activity.
    Li Z; Wang D; Na X; Schoen SR; Messing EM; Wu G
    EMBO J; 2003 Apr; 22(8):1857-67. PubMed ID: 12682018
    [TBL] [Abstract][Full Text] [Related]  

  • 20. OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha.
    Baek JH; Mahon PC; Oh J; Kelly B; Krishnamachary B; Pearson M; Chan DA; Giaccia AJ; Semenza GL
    Mol Cell; 2005 Feb; 17(4):503-12. PubMed ID: 15721254
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 34.