188 related articles for article (PubMed ID: 11518718)
1. Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis.
Saxena MT; Schroeter EH; Mumm JS; Kopan R
J Biol Chem; 2001 Oct; 276(43):40268-73. PubMed ID: 11518718
[TBL] [Abstract][Full Text] [Related]
2. Notch oncoproteins depend on gamma-secretase/presenilin activity for processing and function.
Das I; Craig C; Funahashi Y; Jung KM; Kim TW; Byers R; Weng AP; Kutok JL; Aster JC; Kitajewski J
J Biol Chem; 2004 Jul; 279(29):30771-80. PubMed ID: 15123653
[TBL] [Abstract][Full Text] [Related]
3. Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling.
Berezovska O; Jack C; McLean P; Aster JC; Hicks C; Xia W; Wolfe MS; Kimberly WT; Weinmaster G; Selkoe DJ; Hyman BT
J Neurochem; 2000 Aug; 75(2):583-93. PubMed ID: 10899933
[TBL] [Abstract][Full Text] [Related]
4. The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments.
LaVoie MJ; Selkoe DJ
J Biol Chem; 2003 Sep; 278(36):34427-37. PubMed ID: 12826675
[TBL] [Abstract][Full Text] [Related]
5. A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1.
Mumm JS; Schroeter EH; Saxena MT; Griesemer A; Tian X; Pan DJ; Ray WJ; Kopan R
Mol Cell; 2000 Feb; 5(2):197-206. PubMed ID: 10882062
[TBL] [Abstract][Full Text] [Related]
6. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.
De Strooper B; Annaert W; Cupers P; Saftig P; Craessaerts K; Mumm JS; Schroeter EH; Schrijvers V; Wolfe MS; Ray WJ; Goate A; Kopan R
Nature; 1999 Apr; 398(6727):518-22. PubMed ID: 10206645
[TBL] [Abstract][Full Text] [Related]
7. Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression.
Lleó A; Berezovska O; Ramdya P; Fukumoto H; Raju S; Shah T; Hyman BT
J Biol Chem; 2003 Nov; 278(48):47370-5. PubMed ID: 12960155
[TBL] [Abstract][Full Text] [Related]
8. Evidence that C promoter-binding factor 1 binding is required for Notch-1-mediated repression of activator protein-1.
Chu J; Bresnick EH
J Biol Chem; 2004 Mar; 279(13):12337-45. PubMed ID: 14645224
[TBL] [Abstract][Full Text] [Related]
9. Functional implications of the presenilin dimerization: reconstitution of gamma-secretase activity by assembly of a catalytic site at the dimer interface of two catalytically inactive presenilins.
Cervantes S; Saura CA; Pomares E; Gonzàlez-Duarte R; Marfany G
J Biol Chem; 2004 Aug; 279(35):36519-29. PubMed ID: 15220354
[TBL] [Abstract][Full Text] [Related]
10. Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1.
Zhang Z; Nadeau P; Song W; Donoviel D; Yuan M; Bernstein A; Yankner BA
Nat Cell Biol; 2000 Jul; 2(7):463-5. PubMed ID: 10878814
[No Abstract] [Full Text] [Related]
11. Regulated intramembrane proteolysis of the p75 neurotrophin receptor modulates its association with the TrkA receptor.
Jung KM; Tan S; Landman N; Petrova K; Murray S; Lewis R; Kim PK; Kim DS; Ryu SH; Chao MV; Kim TW
J Biol Chem; 2003 Oct; 278(43):42161-9. PubMed ID: 12913006
[TBL] [Abstract][Full Text] [Related]
12. Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s).
Kimberly WT; Esler WP; Ye W; Ostaszewski BL; Gao J; Diehl T; Selkoe DJ; Wolfe MS
Biochemistry; 2003 Jan; 42(1):137-44. PubMed ID: 12515548
[TBL] [Abstract][Full Text] [Related]
13. aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation.
Francis R; McGrath G; Zhang J; Ruddy DA; Sym M; Apfeld J; Nicoll M; Maxwell M; Hai B; Ellis MC; Parks AL; Xu W; Li J; Gurney M; Myers RL; Himes CS; Hiebsch R; Ruble C; Nye JS; Curtis D
Dev Cell; 2002 Jul; 3(1):85-97. PubMed ID: 12110170
[TBL] [Abstract][Full Text] [Related]
14. The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner.
Kimberly WT; Zheng JB; Guénette SY; Selkoe DJ
J Biol Chem; 2001 Oct; 276(43):40288-92. PubMed ID: 11544248
[TBL] [Abstract][Full Text] [Related]
15. Notch1 and amyloid precursor protein are competitive substrates for presenilin1-dependent gamma-secretase cleavage.
Berezovska O; Jack C; Deng A; Gastineau N; Rebeck GW; Hyman BT
J Biol Chem; 2001 Aug; 276(32):30018-23. PubMed ID: 11408475
[TBL] [Abstract][Full Text] [Related]
16. Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.
Okochi M; Steiner H; Fukumori A; Tanii H; Tomita T; Tanaka T; Iwatsubo T; Kudo T; Takeda M; Haass C
EMBO J; 2002 Oct; 21(20):5408-16. PubMed ID: 12374741
[TBL] [Abstract][Full Text] [Related]
17. Mutations at the P1' position of Notch1 decrease intracellular domain stability rather than cleavage by gamma-secretase.
Blat Y; Meredith JE; Wang Q; Bradley JD; Thompson LA; Olson RE; Stern AM; Seiffert D
Biochem Biophys Res Commun; 2002 Dec; 299(4):569-73. PubMed ID: 12459176
[TBL] [Abstract][Full Text] [Related]
18. Notch receptor cleavage depends on but is not directly executed by presenilins.
Taniguchi Y; Karlström H; Lundkvist J; Mizutani T; Otaka A; Vestling M; Bernstein A; Donoviel D; Lendahl U; Honjo T
Proc Natl Acad Sci U S A; 2002 Mar; 99(6):4014-9. PubMed ID: 11891288
[TBL] [Abstract][Full Text] [Related]
19. Rapid Notch1 nuclear translocation after ligand binding depends on presenilin-associated gamma-secretase activity.
Berezovska O; Jack C; McLean P; Aster JC; Hicks C; Xia W; Wolfe MS; Weinmaster G; Selkoe DJ; Hyman BT
Ann N Y Acad Sci; 2000; 920():223-6. PubMed ID: 11193154
[TBL] [Abstract][Full Text] [Related]
20. Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch.
Chen F; Gu Y; Hasegawa H; Ruan X; Arawaka S; Fraser P; Westaway D; Mount H; St George-Hyslop P
J Biol Chem; 2002 Sep; 277(39):36521-6. PubMed ID: 12119298
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
