BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

171 related articles for article (PubMed ID: 11530021)

  • 1. Effects of five-tryptophan mutations on structure, stability and function of Escherichia coli dihydrofolate reductase.
    Ohmae E; Sasaki Y; Gekko K
    J Biochem; 2001 Sep; 130(3):439-47. PubMed ID: 11530021
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Vacuum-Ultraviolet Circular Dichroism Spectra of Escherichia coli Dihydrofolate Reductase and Its Mutants: Contributions of Phenylalanine and Tyrosine Side Chains and Exciton Coupling of Two Tryptophan Side Chains.
    Ohmae E; Tanaka S; Miyashita Y; Katayanagi K; Matsuo K
    J Phys Chem B; 2015 Oct; 119(41):13002-8. PubMed ID: 26407224
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Multistate equilibrium unfolding of Escherichia coli dihydrofolate reductase: thermodynamic and spectroscopic description of the native, intermediate, and unfolded ensembles.
    Ionescu RM; Smith VF; O'Neill JC; Matthews CR
    Biochemistry; 2000 Aug; 39(31):9540-50. PubMed ID: 10924151
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Effects of mutation at methionine-42 of Escherichia coli dihydrofolate reductase on stability and function: implication of hydrophobic interactions.
    Ohmae E; Fukumizu Y; Iwakura M; Gekko K
    J Biochem; 2005 May; 137(5):643-52. PubMed ID: 15944418
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Acid and thermal unfolding of Escherichia coli dihydrofolate reductase.
    Ohmae E; Kurumiya T; Makino S; Gekko K
    J Biochem; 1996 Nov; 120(5):946-53. PubMed ID: 8982861
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The coordination of the isomerization of a conserved non-prolyl cis peptide bond with the rate-limiting steps in the folding of dihydrofolate reductase.
    Svensson AK; O'Neill JC; Matthews CR
    J Mol Biol; 2003 Feb; 326(2):569-83. PubMed ID: 12559923
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Pivotal role of Gly 121 in dihydrofolate reductase from Escherichia coli: the altered structure of a mutant enzyme may form the basis of its diminished catalytic performance.
    Swanwick RS; Shrimpton PJ; Allemann RK
    Biochemistry; 2004 Apr; 43(14):4119-27. PubMed ID: 15065854
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Stopped-flow NMR spectroscopy: real-time unfolding studies of 6-19F-tryptophan-labeled Escherichia coli dihydrofolate reductase.
    Hoeltzli SD; Frieden C
    Proc Natl Acad Sci U S A; 1995 Sep; 92(20):9318-22. PubMed ID: 7568125
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Solvent environments significantly affect the enzymatic function of Escherichia coli dihydrofolate reductase: comparison of wild-type protein and active-site mutant D27E.
    Ohmae E; Miyashita Y; Tate S; Gekko K; Kitazawa S; Kitahara R; Kuwajima K
    Biochim Biophys Acta; 2013 Dec; 1834(12):2782-94. PubMed ID: 24140567
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Refolding of [6-19F]tryptophan-labeled Escherichia coli dihydrofolate reductase in the presence of ligand: a stopped-flow NMR spectroscopy study.
    Hoeltzli SD; Frieden C
    Biochemistry; 1998 Jan; 37(1):387-98. PubMed ID: 9425060
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Effects of point mutations at the flexible loop alanine-145 of Escherichia coli dihydrofolate reductase on its stability and function.
    Ohmae E; Ishimura K; Iwakura M; Gekko K
    J Biochem; 1998 May; 123(5):839-46. PubMed ID: 9562614
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Nonadditive effects of double mutations at the flexible loops, glycine-67 and glycine-121, of Escherichia coli dihydrofolate reductase on its stability and function.
    Ohmae E; Iriyama K; Ichihara S; Gekko K
    J Biochem; 1998 Jan; 123(1):33-41. PubMed ID: 9504406
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Real-time refolding studies of 6-19F-tryptophan labeled Escherichia coli dihydrofolate reductase using stopped-flow NMR spectroscopy.
    Hoeltzli SD; Frieden C
    Biochemistry; 1996 Dec; 35(51):16843-51. PubMed ID: 8988023
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Effects of point mutations in a hinge region on the stability, folding, and enzymatic activity of Escherichia coli dihydrofolate reductase.
    Ahrweiler PM; Frieden C
    Biochemistry; 1991 Aug; 30(31):7801-9. PubMed ID: 1868058
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Effects of point mutations at the flexible loop glycine-67 of Escherichia coli dihydrofolate reductase on its stability and function.
    Ohmae E; Iriyama K; Ichihara S; Gekko K
    J Biochem; 1996 Apr; 119(4):703-10. PubMed ID: 8743572
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Effects of single-tryptophan mutations on R67 dihydrofolate reductase.
    West FW; Seo HS; Bradrick TD; Howell EE
    Biochemistry; 2000 Apr; 39(13):3678-89. PubMed ID: 10736167
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Investigation of the functional role of tryptophan-22 in Escherichia coli dihydrofolate reductase by site-directed mutagenesis.
    Warren MS; Brown KA; Farnum MF; Howell EE; Kraut J
    Biochemistry; 1991 Nov; 30(46):11092-103. PubMed ID: 1932031
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Detection of a stable intermediate in the thermal unfolding of a cysteine-free form of dihydrofolate reductase from Escherichia coli.
    Luo J; Iwakura M; Matthews CR
    Biochemistry; 1995 Aug; 34(33):10669-75. PubMed ID: 7654721
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Contributions of tryptophan side chains to the circular dichroism of globular proteins: exciton couplets and coupled oscillators.
    Grishina IB; Woody RW
    Faraday Discuss; 1994; (99):245-62. PubMed ID: 7549540
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Effects of point mutation in a flexible loop on the stability and enzymatic function of Escherichia coli dihydrofolate reductase.
    Gekko K; Yamagami K; Kunori Y; Ichihara S; Kodama M; Iwakura M
    J Biochem; 1993 Jan; 113(1):74-80. PubMed ID: 8454578
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.