BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

130 related articles for article (PubMed ID: 11546782)

  • 1. Homodimerization of human bilirubin-uridine-diphosphoglucuronate glucuronosyltransferase-1 (UGT1A1) and its functional implications.
    Ghosh SS; Sappal BS; Kalpana GV; Lee SW; Chowdhury JR; Chowdhury NR
    J Biol Chem; 2001 Nov; 276(45):42108-15. PubMed ID: 11546782
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Genetic lesions of bilirubin uridine-diphosphoglucuronate glucuronosyltransferase (UGT1A1) causing Crigler-Najjar and Gilbert syndromes: correlation of genotype to phenotype.
    Kadakol A; Ghosh SS; Sappal BS; Sharma G; Chowdhury JR; Chowdhury NR
    Hum Mutat; 2000 Oct; 16(4):297-306. PubMed ID: 11013440
    [TBL] [Abstract][Full Text] [Related]  

  • 3. cDNA cloning and functional analysis of minipig uridine diphosphate-glucuronosyltransferase 1A1.
    Miyake Y; Mayumi K; Jinno H; Tanaka-Kagawa T; Narimatsu S; Hanioka N
    Biol Pharm Bull; 2013; 36(3):452-61. PubMed ID: 23449330
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Role of cysteine residues in the function of human UDP glucuronosyltransferase isoform 1A1 (UGT1A1).
    Ghosh SS; Lu Y; Lee SW; Wang X; Guha C; Roy-Chowdhury J; Roy-Chowdhury N
    Biochem J; 2005 Dec; 392(Pt 3):685-92. PubMed ID: 16171463
    [TBL] [Abstract][Full Text] [Related]  

  • 5. A non-immunogenic adenoviral vector, coexpressing CTLA4Ig and bilirubin-uridine-diphosphoglucuronateglucuronosyltransferase permits long-term, repeatable transgene expression in the Gunn rat model of Crigler-Najjar syndrome.
    Thummala NR; Ghosh SS; Lee SW; Reddy B; Davidson A; Horwitz MS; Chowdhury JR; Chowdhury NR
    Gene Ther; 2002 Aug; 9(15):981-90. PubMed ID: 12101428
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Quantitative Systems Pharmacology Model of hUGT1A1-modRNA Encoding for the UGT1A1 Enzyme to Treat Crigler-Najjar Syndrome Type 1.
    Apgar JF; Tang JP; Singh P; Balasubramanian N; Burke J; Hodges MR; Lasaro MA; Lin L; Millard BL; Moore K; Jun LS; Sobolov S; Wilkins AK; Gao X
    CPT Pharmacometrics Syst Pharmacol; 2018 Jun; 7(6):404-412. PubMed ID: 29637732
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Lentiviral vectors that express UGT1A1 in liver and contain miR-142 target sequences normalize hyperbilirubinemia in Gunn rats.
    Schmitt F; Remy S; Dariel A; Flageul M; Pichard V; Boni S; Usal C; Myara A; Laplanche S; Anegon I; Labrune P; Podevin G; Ferry N; Nguyen TH
    Gastroenterology; 2010 Sep; 139(3):999-1007, 1007.e1-2. PubMed ID: 20546738
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Influence of mutations associated with Gilbert and Crigler-Najjar type II syndromes on the glucuronidation kinetics of bilirubin and other UDP-glucuronosyltransferase 1A substrates.
    Udomuksorn W; Elliot DJ; Lewis BC; Mackenzie PI; Yoovathaworn K; Miners JO
    Pharmacogenet Genomics; 2007 Dec; 17(12):1017-29. PubMed ID: 18004206
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Single hepatic venous injection of liver-specific naked plasmid vector expressing human UGT1A1 leads to long-term correction of hyperbilirubinemia and prevention of chronic bilirubin toxicity in Gunn rats.
    Jia Z; Dankó I
    Hum Gene Ther; 2005 Aug; 16(8):985-95. PubMed ID: 16076256
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Required buried alpha-helical structure in the bilirubin UDP-glucuronosyltransferase, UGT1A1, contains a nonreplaceable phenylalanine.
    Ciotti M; Cho JW; George J; Owens IS
    Biochemistry; 1998 Aug; 37(31):11018-25. PubMed ID: 9692996
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Nonviral gene transfer into liver and muscle for treatment of hyperbilirubinemia in the gunn rat.
    Dankó I; Jia Z; Zhang G
    Hum Gene Ther; 2004 Dec; 15(12):1279-86. PubMed ID: 15684703
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Bacterial Outer Membrane Vesicles from Dextran Sulfate Sodium-Induced Colitis Differentially Regulate Intestinal UDP-Glucuronosyltransferase 1A1 Partially Through Toll-Like Receptor 4/Mitogen-Activated Protein Kinase/Phosphatidylinositol 3-Kinase Pathway.
    Gao XJ; Li T; Wei B; Yan ZX; Hu N; Huang YJ; Han BL; Wai TS; Yang W; Yan R
    Drug Metab Dispos; 2018 Mar; 46(3):292-302. PubMed ID: 29311138
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Activation of glucuronidation through reduction of a disulfide bond in rat UDP-glucuronosyltransferase 1A6.
    Ikushiro S; Emi Y; Iyanagi T
    Biochemistry; 2002 Oct; 41(42):12813-20. PubMed ID: 12379124
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Glucuronidation of etoposide in human liver microsomes is specifically catalyzed by UDP-glucuronosyltransferase 1A1.
    Watanabe Y; Nakajima M; Ohashi N; Kume T; Yokoi T
    Drug Metab Dispos; 2003 May; 31(5):589-95. PubMed ID: 12695347
    [TBL] [Abstract][Full Text] [Related]  

  • 15. N-Glucuronidation of the antiepileptic drug retigabine: results from studies with human volunteers, heterologously expressed human UGTs, human liver, kidney, and liver microsomal membranes of Crigler-Najjar type II.
    Borlak J; Gasparic A; Locher M; Schupke H; Hermann R
    Metabolism; 2006 Jun; 55(6):711-21. PubMed ID: 16713428
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes.
    Iyer L; King CD; Whitington PF; Green MD; Roy SK; Tephly TR; Coffman BL; Ratain MJ
    J Clin Invest; 1998 Feb; 101(4):847-54. PubMed ID: 9466980
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Evidence for phosphorylation requirement for human bilirubin UDP-glucuronosyltransferase (UGT1A1) activity.
    Basu NK; Kole L; Owens IS
    Biochem Biophys Res Commun; 2003 Mar; 303(1):98-104. PubMed ID: 12646172
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Discrimination between Crigler-Najjar type I and II by expression of mutant bilirubin uridine diphosphate-glucuronosyltransferase.
    Seppen J; Bosma PJ; Goldhoorn BG; Bakker CT; Chowdhury JR; Chowdhury NR; Jansen PL; Oude Elferink RP
    J Clin Invest; 1994 Dec; 94(6):2385-91. PubMed ID: 7989595
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Rapid proteasomal degradation of translocation-deficient UDP-glucuronosyltransferase 1A1 proteins in patients with Crigler-Najjar type II.
    Ohnishi A; Emi Y
    Biochem Biophys Res Commun; 2003 Oct; 310(3):735-41. PubMed ID: 14550264
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Correction of the UDP-glucuronosyltransferase gene defect in the gunn rat model of crigler-najjar syndrome type I with a chimeric oligonucleotide.
    Kren BT; Parashar B; Bandyopadhyay P; Chowdhury NR; Chowdhury JR; Steer CJ
    Proc Natl Acad Sci U S A; 1999 Aug; 96(18):10349-54. PubMed ID: 10468611
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.