BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

523 related articles for article (PubMed ID: 11551186)

  • 1. The tetrahymena ribozyme cleaves a 5'-methylene phosphonate monoester approximately 10(2)-fold faster than a normal phosphate diester: implications for enzyme catalysis of phosphoryl transfer reactions.
    Liao X; Anjaneyulu PS; Curley JF; Hsu M; Boehringer M; Caruthers MH; Piccirilli JA
    Biochemistry; 2001 Sep; 40(37):10911-26. PubMed ID: 11551186
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Ribozyme-catalyzed and nonenzymatic reactions of phosphate diesters: rate effects upon substitution of sulfur for a nonbridging phosphoryl oxygen atom.
    Herschlag D; Piccirilli JA; Cech TR
    Biochemistry; 1991 May; 30(20):4844-54. PubMed ID: 2036355
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Contributions of 2'-hydroxyl groups of the RNA substrate to binding and catalysis by the Tetrahymena ribozyme. An energetic picture of an active site composed of RNA.
    Herschlag D; Eckstein F; Cech TR
    Biochemistry; 1993 Aug; 32(32):8299-311. PubMed ID: 7688572
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Leaving group stabilization by metal ion coordination and hydrogen bond donation is an evolutionarily conserved feature of group I introns.
    Kuo LY; Piccirilli JA
    Biochim Biophys Acta; 2001 Dec; 1522(3):158-66. PubMed ID: 11779630
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The role of the cleavage site 2'-hydroxyl in the Tetrahymena group I ribozyme reaction.
    Yoshida A; Shan So; Herschlag D; Piccirilli JA
    Chem Biol; 2000 Feb; 7(2):85-96. PubMed ID: 10662698
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The importance of being ribose at the cleavage site in the Tetrahymena ribozyme reaction.
    Herschlag D; Eckstein F; Cech TR
    Biochemistry; 1993 Aug; 32(32):8312-21. PubMed ID: 7688573
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Use of binding energy by an RNA enzyme for catalysis by positioning and substrate destabilization.
    Narlikar GJ; Gopalakrishnan V; McConnell TS; Usman N; Herschlag D
    Proc Natl Acad Sci U S A; 1995 Apr; 92(9):3668-72. PubMed ID: 7731962
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Characterization of a local folding event of the Tetrahymena group I ribozyme: effects of oligonucleotide substrate length, pH, and temperature on the two substrate binding steps.
    Narlikar GJ; Bartley LE; Khosla M; Herschlag D
    Biochemistry; 1999 Oct; 38(43):14192-204. PubMed ID: 10571993
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Promiscuous catalysis by the tetrahymena group I ribozyme.
    Forconi M; Herschlag D
    J Am Chem Soc; 2005 May; 127(17):6160-1. PubMed ID: 15853307
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Probing the role of metal ions in RNA catalysis: kinetic and thermodynamic characterization of a metal ion interaction with the 2'-moiety of the guanosine nucleophile in the Tetrahymena group I ribozyme.
    Shan SO; Herschlag D
    Biochemistry; 1999 Aug; 38(34):10958-75. PubMed ID: 10460151
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Conversion of a group II intron into a new multiple-turnover ribozyme that selectively cleaves oligonucleotides: elucidation of reaction mechanism and structure/function relationships.
    Michels WJ; Pyle AM
    Biochemistry; 1995 Mar; 34(9):2965-77. PubMed ID: 7893710
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Guanosine binding to the Tetrahymena ribozyme: thermodynamic coupling with oligonucleotide binding.
    McConnell TS; Cech TR; Herschlag D
    Proc Natl Acad Sci U S A; 1993 Sep; 90(18):8362-6. PubMed ID: 8378306
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Catalysis of RNA cleavage by a ribozyme derived from the group I intron of Anabaena pre-tRNA(Leu).
    Zaug AJ; Dávila-Aponte JA; Cech TR
    Biochemistry; 1994 Dec; 33(49):14935-47. PubMed ID: 7527660
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The P5abc peripheral element facilitates preorganization of the tetrahymena group I ribozyme for catalysis.
    Engelhardt MA; Doherty EA; Knitt DS; Doudna JA; Herschlag D
    Biochemistry; 2000 Mar; 39(10):2639-51. PubMed ID: 10704214
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Catalysis of RNA cleavage by the Tetrahymena thermophila ribozyme. 1. Kinetic description of the reaction of an RNA substrate complementary to the active site.
    Herschlag D; Cech TR
    Biochemistry; 1990 Nov; 29(44):10159-71. PubMed ID: 2271645
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Evidence for processivity and two-step binding of the RNA substrate from studies of J1/2 mutants of the Tetrahymena ribozyme.
    Herschlag D
    Biochemistry; 1992 Feb; 31(5):1386-99. PubMed ID: 1736996
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Probing the role of a secondary structure element at the 5'- and 3'-splice sites in group I intron self-splicing: the tetrahymena L-16 ScaI ribozyme reveals a new role of the G.U pair in self-splicing.
    Karbstein K; Lee J; Herschlag D
    Biochemistry; 2007 Apr; 46(16):4861-75. PubMed ID: 17385892
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Comparison of pH dependencies of the Tetrahymena ribozyme reactions with RNA 2'-substituted and phosphorothioate substrates reveals a rate-limiting conformational step.
    Herschlag D; Khosla M
    Biochemistry; 1994 May; 33(17):5291-7. PubMed ID: 8172903
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Mechanistic investigations of a ribozyme derived from the Tetrahymena group I intron: insights into catalysis and the second step of self-splicing.
    Mei R; Herschlag D
    Biochemistry; 1996 May; 35(18):5796-809. PubMed ID: 8639540
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Defining the catalytic metal ion interactions in the Tetrahymena ribozyme reaction.
    Shan S; Kravchuk AV; Piccirilli JA; Herschlag D
    Biochemistry; 2001 May; 40(17):5161-71. PubMed ID: 11318638
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 27.