509 related articles for article (PubMed ID: 11583623)
1. A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death.
Suzuki Y; Imai Y; Nakayama H; Takahashi K; Takio K; Takahashi R
Mol Cell; 2001 Sep; 8(3):613-21. PubMed ID: 11583623
[TBL] [Abstract][Full Text] [Related]
2. The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif.
Martins LM; Iaccarino I; Tenev T; Gschmeissner S; Totty NF; Lemoine NR; Savopoulos J; Gray CW; Creasy CL; Dingwall C; Downward J
J Biol Chem; 2002 Jan; 277(1):439-44. PubMed ID: 11602612
[TBL] [Abstract][Full Text] [Related]
3. HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins.
Verhagen AM; Silke J; Ekert PG; Pakusch M; Kaufmann H; Connolly LM; Day CL; Tikoo A; Burke R; Wrobel C; Moritz RL; Simpson RJ; Vaux DL
J Biol Chem; 2002 Jan; 277(1):445-54. PubMed ID: 11604410
[TBL] [Abstract][Full Text] [Related]
4. Mitochondrial protease Omi/HtrA2 enhances caspase activation through multiple pathways.
Suzuki Y; Takahashi-Niki K; Akagi T; Hashikawa T; Takahashi R
Cell Death Differ; 2004 Feb; 11(2):208-16. PubMed ID: 14605674
[TBL] [Abstract][Full Text] [Related]
5. Binding specificity and regulation of the serine protease and PDZ domains of HtrA2/Omi.
Martins LM; Turk BE; Cowling V; Borg A; Jarrell ET; Cantley LC; Downward J
J Biol Chem; 2003 Dec; 278(49):49417-27. PubMed ID: 14512424
[TBL] [Abstract][Full Text] [Related]
6. Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction.
Hegde R; Srinivasula SM; Zhang Z; Wassell R; Mukattash R; Cilenti L; DuBois G; Lazebnik Y; Zervos AS; Fernandes-Alnemri T; Alnemri ES
J Biol Chem; 2002 Jan; 277(1):432-8. PubMed ID: 11606597
[TBL] [Abstract][Full Text] [Related]
7. Smac3, a novel Smac/DIABLO splicing variant, attenuates the stability and apoptosis-inhibiting activity of X-linked inhibitor of apoptosis protein.
Fu J; Jin Y; Arend LJ
J Biol Chem; 2003 Dec; 278(52):52660-72. PubMed ID: 14523016
[TBL] [Abstract][Full Text] [Related]
8. Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP.
Vucic D; Franklin MC; Wallweber HJ; Das K; Eckelman BP; Shin H; Elliott LO; Kadkhodayan S; Deshayes K; Salvesen GS; Fairbrother WJ
Biochem J; 2005 Jan; 385(Pt 1):11-20. PubMed ID: 15485396
[TBL] [Abstract][Full Text] [Related]
9. Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2.
Srinivasula SM; Gupta S; Datta P; Zhang Z; Hegde R; Cheong N; Fernandes-Alnemri T; Alnemri ES
J Biol Chem; 2003 Aug; 278(34):31469-72. PubMed ID: 12835328
[TBL] [Abstract][Full Text] [Related]
10. Variations in the protein level of Omi/HtrA2 in the heart of aged rats may contribute to the increased susceptibility of cardiomyocytes to ischemia/reperfusion injury and cell death : Omi/HtrA2 and aged heart injury.
Wang K; Zhang J; Liu J; Tian J; Wu Y; Wang X; Quan L; Xu H; Wang W; Liu H
Age (Dordr); 2013 Jun; 35(3):733-46. PubMed ID: 22535253
[TBL] [Abstract][Full Text] [Related]
11. Requirement of both the second and third BIR domains for the relief of X-linked inhibitor of apoptosis protein (XIAP)-mediated caspase inhibition by Smac.
Huang Y; Rich RL; Myszka DG; Wu H
J Biol Chem; 2003 Dec; 278(49):49517-22. PubMed ID: 14512414
[TBL] [Abstract][Full Text] [Related]
12. Omi/HtrA2 promotes cell death by binding and degrading the anti-apoptotic protein ped/pea-15.
Trencia A; Fiory F; Maitan MA; Vito P; Barbagallo AP; Perfetti A; Miele C; Ungaro P; Oriente F; Cilenti L; Zervos AS; Formisano P; Beguinot F
J Biol Chem; 2004 Nov; 279(45):46566-72. PubMed ID: 15328349
[TBL] [Abstract][Full Text] [Related]
13. Omi/HtrA2 catalytic cleavage of inhibitor of apoptosis (IAP) irreversibly inactivates IAPs and facilitates caspase activity in apoptosis.
Yang QH; Church-Hajduk R; Ren J; Newton ML; Du C
Genes Dev; 2003 Jun; 17(12):1487-96. PubMed ID: 12815069
[TBL] [Abstract][Full Text] [Related]
14. The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity.
van Loo G; van Gurp M; Depuydt B; Srinivasula SM; Rodriguez I; Alnemri ES; Gevaert K; Vandekerckhove J; Declercq W; Vandenabeele P
Cell Death Differ; 2002 Jan; 9(1):20-6. PubMed ID: 11803371
[TBL] [Abstract][Full Text] [Related]
15. Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice.
Martins LM; Morrison A; Klupsch K; Fedele V; Moisoi N; Teismann P; Abuin A; Grau E; Geppert M; Livi GP; Creasy CL; Martin A; Hargreaves I; Heales SJ; Okada H; Brandner S; Schulz JB; Mak T; Downward J
Mol Cell Biol; 2004 Nov; 24(22):9848-62. PubMed ID: 15509788
[TBL] [Abstract][Full Text] [Related]
16. Autocatalytic processing of HtrA2/Omi is essential for induction of caspase-dependent cell death through antagonizing XIAP.
Seong YM; Choi JY; Park HJ; Kim KJ; Ahn SG; Seong GH; Kim IK; Kang S; Rhim H
J Biol Chem; 2004 Sep; 279(36):37588-96. PubMed ID: 15201285
[TBL] [Abstract][Full Text] [Related]
17. Motoneuron resistance to apoptotic cell death in vivo correlates with the ratio between X-linked inhibitor of apoptosis proteins (XIAPs) and its inhibitor, XIAP-associated factor 1.
Perrelet D; Perrin FE; Liston P; Korneluk RG; MacKenzie A; Ferrer-Alcon M; Kato AC
J Neurosci; 2004 Apr; 24(15):3777-85. PubMed ID: 15084658
[TBL] [Abstract][Full Text] [Related]
18. Akt attenuation of the serine protease activity of HtrA2/Omi through phosphorylation of serine 212.
Yang L; Sun M; Sun XM; Cheng GZ; Nicosia SV; Cheng JQ
J Biol Chem; 2007 Apr; 282(15):10981-7. PubMed ID: 17311912
[TBL] [Abstract][Full Text] [Related]
19. Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway.
Srinivasula SM; Datta P; Fan XJ; Fernandes-Alnemri T; Huang Z; Alnemri ES
J Biol Chem; 2000 Nov; 275(46):36152-7. PubMed ID: 10950947
[TBL] [Abstract][Full Text] [Related]
20. Proteasome-mediated degradation of Smac during apoptosis: XIAP promotes Smac ubiquitination in vitro.
MacFarlane M; Merrison W; Bratton SB; Cohen GM
J Biol Chem; 2002 Sep; 277(39):36611-6. PubMed ID: 12121969
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]