103 related articles for article (PubMed ID: 11587708)
1. Evidence for distinct conformations of the two alpha 1 subunits in diazepam-bound GABA(A) receptors.
Williams DB; Akabas MH
Neuropharmacology; 2001 Oct; 41(5):539-45. PubMed ID: 11587708
[TBL] [Abstract][Full Text] [Related]
2. Benzodiazepines induce a conformational change in the region of the gamma-aminobutyric acid type A receptor alpha(1)-subunit M3 membrane-spanning segment.
Williams DB; Akabas MH
Mol Pharmacol; 2000 Nov; 58(5):1129-36. PubMed ID: 11040062
[TBL] [Abstract][Full Text] [Related]
3. Structural evidence that propofol stabilizes different GABA(A) receptor states at potentiating and activating concentrations.
Williams DB; Akabas MH
J Neurosci; 2002 Sep; 22(17):7417-24. PubMed ID: 12196563
[TBL] [Abstract][Full Text] [Related]
4. Gamma-aminobutyric acid increases the water accessibility of M3 membrane-spanning segment residues in gamma-aminobutyric acid type A receptors.
Williams DB; Akabas MH
Biophys J; 1999 Nov; 77(5):2563-74. PubMed ID: 10545357
[TBL] [Abstract][Full Text] [Related]
5. Identification of transduction elements for benzodiazepine modulation of the GABA(A) receptor: three residues are required for allosteric coupling.
Boileau AJ; Czajkowski C
J Neurosci; 1999 Dec; 19(23):10213-20. PubMed ID: 10575018
[TBL] [Abstract][Full Text] [Related]
6. Diazepam enhancement of GABA-gated currents in binary and ternary GABAA receptors: relationship to benzodiazepine binding site density.
Granja R; Gunnersen D; Wong G; Valeyev A; Skolnick P
J Mol Neurosci; 1997 Dec; 9(3):187-95. PubMed ID: 9481620
[TBL] [Abstract][Full Text] [Related]
7. Natural mutation of GABAA receptor alpha 6 subunit alters benzodiazepine affinity but not allosteric GABA effects.
Korpi ER; Seeburg PH
Eur J Pharmacol; 1993 Sep; 247(1):23-7. PubMed ID: 8258357
[TBL] [Abstract][Full Text] [Related]
8. Allosteric uncoupling and up-regulation of benzodiazepine and GABA recognition sites following chronic diazepam treatment of HEK 293 cells stably transfected with alpha1beta2gamma2S subunits of GABA (A) receptors.
Pericić D; Strac DS; Jembrek MJ; Vlainić J
Naunyn Schmiedebergs Arch Pharmacol; 2007 May; 375(3):177-87. PubMed ID: 17377772
[TBL] [Abstract][Full Text] [Related]
9. Gating-induced conformational rearrangement of the γ-aminobutyric acid type A receptor β-α subunit interface in the membrane-spanning domain.
Bali M; Akabas MH
J Biol Chem; 2012 Aug; 287(33):27762-70. PubMed ID: 22730325
[TBL] [Abstract][Full Text] [Related]
10. Molecular dissection of benzodiazepine binding and allosteric coupling using chimeric gamma-aminobutyric acidA receptor subunits.
Boileau AJ; Kucken AM; Evers AR; Czajkowski C
Mol Pharmacol; 1998 Feb; 53(2):295-303. PubMed ID: 9463488
[TBL] [Abstract][Full Text] [Related]
11. Pharmacology of the human gamma-aminobutyric acidA receptor alpha 4 subunit expressed in Xenopus laevis oocytes.
Whittemore ER; Yang W; Drewe JA; Woodward RM
Mol Pharmacol; 1996 Nov; 50(5):1364-75. PubMed ID: 8913369
[TBL] [Abstract][Full Text] [Related]
12. Positive modulation of synaptic and extrasynaptic GABAA receptors by an antagonist of the high affinity benzodiazepine binding site.
Middendorp SJ; Maldifassi MC; Baur R; Sigel E
Neuropharmacology; 2015 Aug; 95():459-67. PubMed ID: 25963418
[TBL] [Abstract][Full Text] [Related]
13. The anxioselective agent 7-(2-chloropyridin-4-yl)pyrazolo-[1,5-a]-pyrimidin-3-yl](pyridin-2-yl)methanone (DOV 51892) is more efficacious than diazepam at enhancing GABA-gated currents at alpha1 subunit-containing GABAA receptors.
Popik P; Kostakis E; Krawczyk M; Nowak G; Szewczyk B; Krieter P; Chen Z; Russek SJ; Gibbs TT; Farb DH; Skolnick P; Lippa AS; Basile AS
J Pharmacol Exp Ther; 2006 Dec; 319(3):1244-52. PubMed ID: 16971504
[TBL] [Abstract][Full Text] [Related]
14. Covalent modification of GABAA receptor isoforms by a diazepam analogue provides evidence for a novel benzodiazepine binding site that prevents modulation by these drugs.
Baur R; Tan KR; Lüscher BP; Gonthier A; Goeldner M; Sigel E
J Neurochem; 2008 Sep; 106(6):2353-63. PubMed ID: 18643789
[TBL] [Abstract][Full Text] [Related]
15. Two tyrosine residues on the alpha subunit are crucial for benzodiazepine binding and allosteric modulation of gamma-aminobutyric acidA receptors.
Amin J; Brooks-Kayal A; Weiss DS
Mol Pharmacol; 1997 May; 51(5):833-41. PubMed ID: 9145922
[TBL] [Abstract][Full Text] [Related]
16. Cysteine substitutions define etomidate binding and gating linkages in the α-M1 domain of γ-aminobutyric acid type A (GABAA) receptors.
Stewart DS; Hotta M; Li GD; Desai R; Chiara DC; Olsen RW; Forman SA
J Biol Chem; 2013 Oct; 288(42):30373-30386. PubMed ID: 24009076
[TBL] [Abstract][Full Text] [Related]
17. Point mutations of the alpha 1 beta 2 gamma 2 gamma-aminobutyric acid(A) receptor affecting modulation of the channel by ligands of the benzodiazepine binding site.
Buhr A; Baur R; Malherbe P; Sigel E
Mol Pharmacol; 1996 Jun; 49(6):1080-4. PubMed ID: 8649346
[TBL] [Abstract][Full Text] [Related]
18. Allosteric modulators induce distinct movements at the GABA-binding site interface of the GABA-A receptor.
Sancar F; Czajkowski C
Neuropharmacology; 2011; 60(2-3):520-8. PubMed ID: 21093460
[TBL] [Abstract][Full Text] [Related]
19. Benzodiazepines affect channel opening of GABA A receptors induced by either agonist binding site.
Baur R; Sigel E
Mol Pharmacol; 2005 Apr; 67(4):1005-8. PubMed ID: 15657366
[TBL] [Abstract][Full Text] [Related]
20. Residues at positions 206 and 209 of the alpha1 subunit of gamma-aminobutyric AcidA receptors influence affinities for benzodiazepine binding site ligands.
Buhr A; Schaerer MT; Baur R; Sigel E
Mol Pharmacol; 1997 Oct; 52(4):676-82. PubMed ID: 9380031
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]