These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
180 related articles for article (PubMed ID: 11705453)
1. Metabolism of tirapazamine by multiple reductases in the nucleus. Delahoussaye YM; Evans JW; Brown JM Biochem Pharmacol; 2001 Nov; 62(9):1201-9. PubMed ID: 11705453 [TBL] [Abstract][Full Text] [Related]
2. Subcellular Location of Tirapazamine Reduction Dramatically Affects Aerobic but Not Anoxic Cytotoxicity. Guise CP; Abbattista MR; Anderson RF; Li D; Taghipouran R; Tsai A; Lee SJ; Smaill JB; Denny WA; Hay MP; Wilson WR; Hicks KO; Patterson AV Molecules; 2020 Oct; 25(21):. PubMed ID: 33105798 [TBL] [Abstract][Full Text] [Related]
3. Adaptation of human tumor cells to tirapazamine under aerobic conditions: implications of increased antioxidant enzyme activity to mechanism of aerobic cytotoxicity. Elwell JH; Siim BG; Evans JW; Brown JM Biochem Pharmacol; 1997 Jul; 54(2):249-57. PubMed ID: 9271329 [TBL] [Abstract][Full Text] [Related]
4. Enhanced conversion of DNA radical damage to double strand breaks by 1,2,4-benzotriazine 1,4-dioxides linked to a DNA binder compared to tirapazamine. Anderson RF; Harris TA; Hay MP; Denny WA Chem Res Toxicol; 2003 Nov; 16(11):1477-83. PubMed ID: 14615975 [TBL] [Abstract][Full Text] [Related]
5. Cytotoxicity of Tirapazamine (3-Amino-1,2,4-benzotriazine-1,4-dioxide)-Induced DNA Damage in Chicken DT40 Cells. Moriwaki T; Okamoto S; Sasanuma H; Nagasawa H; Takeda S; Masunaga SI; Tano K Chem Res Toxicol; 2017 Feb; 30(2):699-704. PubMed ID: 27943678 [TBL] [Abstract][Full Text] [Related]
6. Reaction of the hypoxia-selective antitumor agent tirapazamine with a C1'-radical in single-stranded and double-stranded DNA: the drug and its metabolites can serve as surrogates for molecular oxygen in radical-mediated DNA damage reactions. Hwang JT; Greenberg MM; Fuchs T; Gates KS Biochemistry; 1999 Oct; 38(43):14248-55. PubMed ID: 10571998 [TBL] [Abstract][Full Text] [Related]
7. DNA damage measured by the comet assay in head and neck cancer patients treated with tirapazamine. Dorie MJ; Kovacs MS; Gabalski EC; Adam M; Le QT; Bloch DA; Pinto HA; Terris DJ; Brown JM Neoplasia; 1999 Nov; 1(5):461-7. PubMed ID: 10933062 [TBL] [Abstract][Full Text] [Related]
8. NADPH:cytochrome c (P450) reductase activates tirapazamine (SR4233) to restore hypoxic and oxic cytotoxicity in an aerobic resistant derivative of the A549 lung cancer cell line. Saunders MP; Patterson AV; Chinje EC; Harris AL; Stratford IJ Br J Cancer; 2000 Feb; 82(3):651-6. PubMed ID: 10682679 [TBL] [Abstract][Full Text] [Related]
9. Non-nuclear localized human NOSII enhances the bioactivation and toxicity of tirapazamine (SR4233) in vitro. Chinje EC; Cowen RL; Feng J; Sharma SP; Wind NS; Harris AL; Stratford IJ Mol Pharmacol; 2003 Jun; 63(6):1248-55. PubMed ID: 12761334 [TBL] [Abstract][Full Text] [Related]
10. Selective potentiation of the hypoxic cytotoxicity of tirapazamine by its 1-N-oxide metabolite SR 4317. Siim BG; Pruijn FB; Sturman JR; Hogg A; Hay MP; Brown JM; Wilson WR Cancer Res; 2004 Jan; 64(2):736-42. PubMed ID: 14744792 [TBL] [Abstract][Full Text] [Related]
11. Exploiting the Inherent Photophysical Properties of the Major Tirapazamine Metabolite in the Development of Profluorescent Substrates for Enzymes That Catalyze the Bioreductive Activation of Hypoxia-Selective Anticancer Prodrugs. Shen X; Laber CH; Sarkar U; Galazzi F; Johnson KM; Mahieu NG; Hillebrand R; Fuchs-Knotts T; Barnes CL; Baker GA; Gates KS J Org Chem; 2018 Mar; 83(6):3126-3131. PubMed ID: 29461834 [TBL] [Abstract][Full Text] [Related]
12. Improved potency of the hypoxic cytotoxin tirapazamine by DNA-targeting. Delahoussaye YM; Hay MP; Pruijn FB; Denny WA; Brown JM Biochem Pharmacol; 2003 Jun; 65(11):1807-15. PubMed ID: 12781332 [TBL] [Abstract][Full Text] [Related]
13. Tirapazamine is metabolized to its DNA-damaging radical by intranuclear enzymes. Evans JW; Yudoh K; Delahoussaye YM; Brown JM Cancer Res; 1998 May; 58(10):2098-101. PubMed ID: 9605751 [TBL] [Abstract][Full Text] [Related]
14. Enzymology of tirapazamine metabolism: a review. Patterson AV; Saunders MP; Chinje EC; Patterson LH; Stratford IJ Anticancer Drug Des; 1998 Sep; 13(6):541-73. PubMed ID: 9755718 [TBL] [Abstract][Full Text] [Related]
15. Enzymology of the reductive bioactivation of SR 4233. A novel benzotriazine di-N-oxide hypoxic cell cytotoxin. Walton MI; Workman P Biochem Pharmacol; 1990 Jun; 39(11):1735-42. PubMed ID: 2344370 [TBL] [Abstract][Full Text] [Related]
16. Photochemical and photobiological studies of tirapazamine (SR 4233) and related quinoxaline 1,4-Di-N-oxide analogues. Inbaraj JJ; Motten AG; Chignell CF Chem Res Toxicol; 2003 Feb; 16(2):164-70. PubMed ID: 12588187 [TBL] [Abstract][Full Text] [Related]
17. Reduction of 3-amino-1,2,4-benzotriazine-1,4-di-N-oxide (tirapazamine, WIN 59075, SR 4233) to a DNA-damaging species: a direct role for NADPH:cytochrome P450 oxidoreductase. Fitzsimmons SA; Lewis AD; Riley RJ; Workman P Carcinogenesis; 1994 Aug; 15(8):1503-10. PubMed ID: 8055626 [TBL] [Abstract][Full Text] [Related]
18. Combination of the bioreductive drug tirapazamine with the chemotherapeutic prodrug cyclophosphamide for P450/P450-reductase-based cancer gene therapy. Jounaidi Y; Waxman DJ Cancer Res; 2000 Jul; 60(14):3761-9. PubMed ID: 10919648 [TBL] [Abstract][Full Text] [Related]
19. DNA strand damage product analysis provides evidence that the tumor cell-specific cytotoxin tirapazamine produces hydroxyl radical and acts as a surrogate for O(2). Chowdhury G; Junnotula V; Daniels JS; Greenberg MM; Gates KS J Am Chem Soc; 2007 Oct; 129(42):12870-7. PubMed ID: 17900117 [TBL] [Abstract][Full Text] [Related]
20. Tirapazamine: a hypoxia-activated topoisomerase II poison. Peters KB; Brown JM Cancer Res; 2002 Sep; 62(18):5248-53. PubMed ID: 12234992 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]