BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

203 related articles for article (PubMed ID: 11716702)

  • 1. Identification and activities of human carboxylesterases for the activation of CPT-11, a clinically approved anticancer drug.
    Senter PD; Beam KS; Mixan B; Wahl AF
    Bioconjug Chem; 2001; 12(6):1074-80. PubMed ID: 11716702
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Comparison of activation of CPT-11 by rabbit and human carboxylesterases for use in enzyme/prodrug therapy.
    Danks MK; Morton CL; Krull EJ; Cheshire PJ; Richmond LB; Naeve CW; Pawlik CA; Houghton PJ; Potter PM
    Clin Cancer Res; 1999 Apr; 5(4):917-24. PubMed ID: 10213229
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Characterization of CPT-11 hydrolysis by human liver carboxylesterase isoforms hCE-1 and hCE-2.
    Humerickhouse R; Lohrbach K; Li L; Bosron WF; Dolan ME
    Cancer Res; 2000 Mar; 60(5):1189-92. PubMed ID: 10728672
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Intracellular conversion of irinotecan to its active form, SN-38, by native carboxylesterase in human non-small cell lung cancer.
    Ohtsuka K; Inoue S; Kameyama M; Kanetoshi A; Fujimoto T; Takaoka K; Araya Y; Shida A
    Lung Cancer; 2003 Aug; 41(2):187-98. PubMed ID: 12871782
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Isolation and partial characterization of a cDNA encoding a rabbit liver carboxylesterase that activates the prodrug irinotecan (CPT-11).
    Potter PM; Pawlik CA; Morton CL; Naeve CW; Danks MK
    Cancer Res; 1998 Jun; 58(12):2646-51. PubMed ID: 9635592
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Overexpression of a rabbit liver carboxylesterase sensitizes human tumor cells to CPT-11.
    Danks MK; Morton CL; Pawlik CA; Potter PM
    Cancer Res; 1998 Jan; 58(1):20-2. PubMed ID: 9426050
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Mouse liver and kidney carboxylesterase (M-LK) rapidly hydrolyzes antitumor prodrug irinotecan and the N-terminal three quarter sequence determines substrate selectivity.
    Xie M; Yang D; Wu M; Xue B; Yan B
    Drug Metab Dispos; 2003 Jan; 31(1):21-7. PubMed ID: 12485949
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Structural constraints affect the metabolism of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) by carboxylesterases.
    Wadkins RM; Morton CL; Weeks JK; Oliver L; Wierdl M; Danks MK; Potter PM
    Mol Pharmacol; 2001 Aug; 60(2):355-62. PubMed ID: 11455023
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structural insights into CPT-11 activation by mammalian carboxylesterases.
    Bencharit S; Morton CL; Howard-Williams EL; Danks MK; Potter PM; Redinbo MR
    Nat Struct Biol; 2002 May; 9(5):337-42. PubMed ID: 11967565
    [TBL] [Abstract][Full Text] [Related]  

  • 10. An improved human carboxylesterase for enzyme/prodrug therapy with CPT-11.
    Wierdl M; Tsurkan L; Hyatt JL; Edwards CC; Hatfield MJ; Morton CL; Houghton PJ; Danks MK; Redinbo MR; Potter PM
    Cancer Gene Ther; 2008 Mar; 15(3):183-92. PubMed ID: 18188187
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Irinotecan activation by human carboxylesterases in colorectal adenocarcinoma cells.
    Wu MH; Yan B; Humerickhouse R; Dolan ME
    Clin Cancer Res; 2002 Aug; 8(8):2696-700. PubMed ID: 12171903
    [TBL] [Abstract][Full Text] [Related]  

  • 12. In vivo human carboxylesterase cDNA gene transfer to activate the prodrug CPT-11 for local treatment of solid tumors.
    Kojima A; Hackett NR; Ohwada A; Crystal RG
    J Clin Invest; 1998 Apr; 101(8):1789-96. PubMed ID: 9541511
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Conversion of the CPT-11 metabolite APC to SN-38 by rabbit liver carboxylesterase.
    Guichard SM; Morton CL; Krull EJ; Stewart CF; Danks MK; Potter PM
    Clin Cancer Res; 1998 Dec; 4(12):3089-94. PubMed ID: 9865925
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Organ-specific carboxylesterase profiling identifies the small intestine and kidney as major contributors of activation of the anticancer prodrug CPT-11.
    Hatfield MJ; Tsurkan L; Garrett M; Shaver TM; Hyatt JL; Edwards CC; Hicks LD; Potter PM
    Biochem Pharmacol; 2011 Jan; 81(1):24-31. PubMed ID: 20833148
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Secreted and tumour targeted human carboxylesterase for activation of irinotecan.
    Oosterhoff D; Pinedo HM; van der Meulen IH; de Graaf M; Sone T; Kruyt FA; van Beusechem VW; Haisma HJ; Gerritsen WR
    Br J Cancer; 2002 Sep; 87(6):659-64. PubMed ID: 12237777
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Bioactivation of the anticancer agent CPT-11 to SN-38 by human hepatic microsomal carboxylesterases and the in vitro assessment of potential drug interactions.
    Slatter JG; Su P; Sams JP; Schaaf LJ; Wienkers LC
    Drug Metab Dispos; 1997 Oct; 25(10):1157-64. PubMed ID: 9321519
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Activation of a camptothecin prodrug by specific carboxylesterases as predicted by quantitative structure-activity relationship and molecular docking studies.
    Yoon KJ; Krull EJ; Morton CL; Bornmann WG; Lee RE; Potter PM; Danks MK
    Mol Cancer Ther; 2003 Nov; 2(11):1171-81. PubMed ID: 14617791
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Conversion of irinotecan (CPT-11) to its active metabolite, 7-ethyl-10-hydroxycamptothecin (SN-38), by human liver carboxylesterase.
    Rivory LP; Bowles MR; Robert J; Pond SM
    Biochem Pharmacol; 1996 Oct; 52(7):1103-11. PubMed ID: 8831730
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Hydrolysis of irinotecan and its oxidative metabolites, 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin and 7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin, by human carboxylesterases CES1A1, CES2, and a newly expressed carboxylesterase isoenzyme, CES3.
    Sanghani SP; Quinney SK; Fredenburg TB; Davis WI; Murry DJ; Bosron WF
    Drug Metab Dispos; 2004 May; 32(5):505-11. PubMed ID: 15100172
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Characterization of inhibitors of specific carboxylesterases: development of carboxylesterase inhibitors for translational application.
    Yoon KJ; Hyatt JL; Morton CL; Lee RE; Potter PM; Danks MK
    Mol Cancer Ther; 2004 Aug; 3(8):903-9. PubMed ID: 15299073
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.