215 related articles for article (PubMed ID: 11741477)
1. Structure of protein tyrosine phosphatase 1B in complex with inhibitors bearing two phosphotyrosine mimetics.
Jia Z; Ye Q; Dinaut AN; Wang Q; Waddleton D; Payette P; Ramachandran C; Kennedy B; Hum G; Taylor SD
J Med Chem; 2001 Dec; 44(26):4584-94. PubMed ID: 11741477
[TBL] [Abstract][Full Text] [Related]
2. Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics.
Groves MR; Yao ZJ; Roller PP; Burke TR; Barford D
Biochemistry; 1998 Dec; 37(51):17773-83. PubMed ID: 9922143
[TBL] [Abstract][Full Text] [Related]
3. Small molecule peptidomimetics containing a novel phosphotyrosine bioisostere inhibit protein tyrosine phosphatase 1B and augment insulin action.
Bleasdale JE; Ogg D; Palazuk BJ; Jacob CS; Swanson ML; Wang XY; Thompson DP; Conradi RA; Mathews WR; Laborde AL; Stuchly CW; Heijbel A; Bergdahl K; Bannow CA; Smith CW; Svensson C; Liljebris C; Schostarez HJ; May PD; Stevens FC; Larsen SD
Biochemistry; 2001 May; 40(19):5642-54. PubMed ID: 11341829
[TBL] [Abstract][Full Text] [Related]
4. Structure-based design and discovery of protein tyrosine phosphatase inhibitors incorporating novel isothiazolidinone heterocyclic phosphotyrosine mimetics.
Combs AP; Yue EW; Bower M; Ala PJ; Wayland B; Douty B; Takvorian A; Polam P; Wasserman Z; Zhu W; Crawley ML; Pruitt J; Sparks R; Glass B; Modi D; McLaughlin E; Bostrom L; Li M; Galya L; Blom K; Hillman M; Gonneville L; Reid BG; Wei M; Becker-Pasha M; Klabe R; Huber R; Li Y; Hollis G; Burn TC; Wynn R; Liu P; Metcalf B
J Med Chem; 2005 Oct; 48(21):6544-8. PubMed ID: 16220970
[TBL] [Abstract][Full Text] [Related]
5. Selective protein tyrosine phosphatase 1B inhibitors: targeting the second phosphotyrosine binding site with non-carboxylic acid-containing ligands.
Liu G; Xin Z; Liang H; Abad-Zapatero C; Hajduk PJ; Janowick DA; Szczepankiewicz BG; Pei Z; Hutchins CW; Ballaron SJ; Stashko MA; Lubben TH; Berg CE; Rondinone CM; Trevillyan JM; Jirousek MR
J Med Chem; 2003 Jul; 46(16):3437-40. PubMed ID: 12877578
[TBL] [Abstract][Full Text] [Related]
6. The structural basis for the selectivity of benzotriazole inhibitors of PTP1B.
Scapin G; Patel SB; Becker JW; Wang Q; Desponts C; Waddleton D; Skorey K; Cromlish W; Bayly C; Therien M; Gauthier JY; Li CS; Lau CK; Ramachandran C; Kennedy BP; Asante-Appiah E
Biochemistry; 2003 Oct; 42(39):11451-9. PubMed ID: 14516196
[TBL] [Abstract][Full Text] [Related]
7. Investigation of potential bioisosteric replacements for the carboxyl groups of peptidomimetic inhibitors of protein tyrosine phosphatase 1B: identification of a tetrazole-containing inhibitor with cellular activity.
Liljebris C; Larsen SD; Ogg D; Palazuk BJ; Bleasdale JE
J Med Chem; 2002 Apr; 45(9):1785-98. PubMed ID: 11960490
[TBL] [Abstract][Full Text] [Related]
8. Discovery and SAR of novel, potent and selective protein tyrosine phosphatase 1B inhibitors.
Pei Z; Li X; Liu G; Abad-Zapatero C; Lubben T; Zhang T; Ballaron SJ; Hutchins CW; Trevillyan JM; Jirousek MR
Bioorg Med Chem Lett; 2003 Oct; 13(19):3129-32. PubMed ID: 12951078
[TBL] [Abstract][Full Text] [Related]
9. Potent benzimidazole sulfonamide protein tyrosine phosphatase 1B inhibitors containing the heterocyclic (S)-isothiazolidinone phosphotyrosine mimetic.
Combs AP; Zhu W; Crawley ML; Glass B; Polam P; Sparks RB; Modi D; Takvorian A; McLaughlin E; Yue EW; Wasserman Z; Bower M; Wei M; Rupar M; Ala PJ; Reid BM; Ellis D; Gonneville L; Emm T; Taylor N; Yeleswaram S; Li Y; Wynn R; Burn TC; Hollis G; Liu PC; Metcalf B
J Med Chem; 2006 Jun; 49(13):3774-89. PubMed ID: 16789735
[TBL] [Abstract][Full Text] [Related]
10. Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design.
Puius YA; Zhao Y; Sullivan M; Lawrence DS; Almo SC; Zhang ZY
Proc Natl Acad Sci U S A; 1997 Dec; 94(25):13420-5. PubMed ID: 9391040
[TBL] [Abstract][Full Text] [Related]
11. Potent, selective inhibitors of protein tyrosine phosphatase 1B.
Xin Z; Oost TK; Abad-Zapatero C; Hajduk PJ; Pei Z; Szczepankiewicz BG; Hutchins CW; Ballaron SJ; Stashko MA; Lubben T; Trevillyan JM; Jirousek MR; Liu G
Bioorg Med Chem Lett; 2003 Jun; 13(11):1887-90. PubMed ID: 12749891
[TBL] [Abstract][Full Text] [Related]
12. Structure-based optimization of protein tyrosine phosphatase 1B inhibitors: from the active site to the second phosphotyrosine binding site.
Wilson DP; Wan ZK; Xu WX; Kirincich SJ; Follows BC; Joseph-McCarthy D; Foreman K; Moretto A; Wu J; Zhu M; Binnun E; Zhang YL; Tam M; Erbe DV; Tobin J; Xu X; Leung L; Shilling A; Tam SY; Mansour TS; Lee J
J Med Chem; 2007 Sep; 50(19):4681-98. PubMed ID: 17705360
[TBL] [Abstract][Full Text] [Related]
13. 1,2,3,4-Tetrahydroisoquinolinyl sulfamic acids as phosphatase PTP1B inhibitors.
Klopfenstein SR; Evdokimov AG; Colson AO; Fairweather NT; Neuman JJ; Maier MB; Gray JL; Gerwe GS; Stake GE; Howard BW; Farmer JA; Pokross ME; Downs TR; Kasibhatla B; Peters KG
Bioorg Med Chem Lett; 2006 Mar; 16(6):1574-8. PubMed ID: 16386905
[TBL] [Abstract][Full Text] [Related]
14. Protein tyrosine phosphatase 1B inhibition: opportunities and challenges.
Liu G
Curr Med Chem; 2003 Aug; 10(15):1407-21. PubMed ID: 12871138
[TBL] [Abstract][Full Text] [Related]
15. Potent and highly selective inhibitors of the protein tyrosine phosphatase 1B.
Taing M; Keng YF; Shen K; Wu L; Lawrence DS; Zhang ZY
Biochemistry; 1999 Mar; 38(12):3793-803. PubMed ID: 10090769
[TBL] [Abstract][Full Text] [Related]
16. In silico structure-based design of a potent and selective small peptide inhibitor of protein tyrosine phosphatase 1B, a novel therapeutic target for obesity and type 2 diabetes mellitus: a computer modeling approach.
Rao GS; Ramachandran MV; Bajaj JS
J Biomol Struct Dyn; 2006 Feb; 23(4):377-84. PubMed ID: 16363874
[TBL] [Abstract][Full Text] [Related]
17. Identification of a monoacid-based, cell permeable, selective inhibitor of protein tyrosine phosphatase 1B.
Xin Z; Liu G; Abad-Zapatero C; Pei Z; Szczepankiewicz BG; Li X; Zhang T; Hutchins CW; Hajduk PJ; Ballaron SJ; Stashko MA; Lubben TH; Trevillyan JM; Jirousek MR
Bioorg Med Chem Lett; 2003 Nov; 13(22):3947-50. PubMed ID: 14592481
[TBL] [Abstract][Full Text] [Related]
18. Novel benzofuran and benzothiophene biphenyls as inhibitors of protein tyrosine phosphatase 1B with antihyperglycemic properties.
Malamas MS; Sredy J; Moxham C; Katz A; Xu W; McDevitt R; Adebayo FO; Sawicki DR; Seestaller L; Sullivan D; Taylor JR
J Med Chem; 2000 Apr; 43(7):1293-310. PubMed ID: 10753467
[TBL] [Abstract][Full Text] [Related]
19. A re-examination of the difluoromethylenesulfonic acid group as a phosphotyrosine mimic for PTP1B inhibition.
Hussain M; Ahmed V; Hill B; Ahmed Z; Taylor SD
Bioorg Med Chem; 2008 Jul; 16(14):6764-77. PubMed ID: 18555687
[TBL] [Abstract][Full Text] [Related]
20. Structural insights into the design of nonpeptidic isothiazolidinone-containing inhibitors of protein-tyrosine phosphatase 1B.
Ala PJ; Gonneville L; Hillman M; Becker-Pasha M; Yue EW; Douty B; Wayland B; Polam P; Crawley ML; McLaughlin E; Sparks RB; Glass B; Takvorian A; Combs AP; Burn TC; Hollis GF; Wynn R
J Biol Chem; 2006 Dec; 281(49):38013-21. PubMed ID: 17028182
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
