BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

304 related articles for article (PubMed ID: 11741961)

  • 1. Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4.
    Lee HJ; Jung KM; Huang YZ; Bennett LB; Lee JS; Mei L; Kim TW
    J Biol Chem; 2002 Feb; 277(8):6318-23. PubMed ID: 11741961
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Presenilin-dependent gamma-secretase processing regulates multiple ERBB4/HER4 activities.
    Vidal GA; Naresh A; Marrero L; Jones FE
    J Biol Chem; 2005 May; 280(20):19777-83. PubMed ID: 15746097
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Nectin-1alpha, an immunoglobulin-like receptor involved in the formation of synapses, is a substrate for presenilin/gamma-secretase-like cleavage.
    Kim DY; Ingano LA; Kovacs DM
    J Biol Chem; 2002 Dec; 277(51):49976-81. PubMed ID: 12376527
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments.
    LaVoie MJ; Selkoe DJ
    J Biol Chem; 2003 Sep; 278(36):34427-37. PubMed ID: 12826675
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Cleavage of p75 neurotrophin receptor by alpha-secretase and gamma-secretase requires specific receptor domains.
    Zampieri N; Xu CF; Neubert TA; Chao MV
    J Biol Chem; 2005 Apr; 280(15):14563-71. PubMed ID: 15701642
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Regulated intramembrane proteolysis of the p75 neurotrophin receptor modulates its association with the TrkA receptor.
    Jung KM; Tan S; Landman N; Petrova K; Murray S; Lewis R; Kim PK; Kim DS; Ryu SH; Chao MV; Kim TW
    J Biol Chem; 2003 Oct; 278(43):42161-9. PubMed ID: 12913006
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Functional implications of the presenilin dimerization: reconstitution of gamma-secretase activity by assembly of a catalytic site at the dimer interface of two catalytically inactive presenilins.
    Cervantes S; Saura CA; Pomares E; Gonzàlez-Duarte R; Marfany G
    J Biol Chem; 2004 Aug; 279(35):36519-29. PubMed ID: 15220354
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide.
    Lammich S; Okochi M; Takeda M; Kaether C; Capell A; Zimmer AK; Edbauer D; Walter J; Steiner H; Haass C
    J Biol Chem; 2002 Nov; 277(47):44754-9. PubMed ID: 12223485
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The insulin-like growth factor 1 (IGF-1) receptor is a substrate for gamma-secretase-mediated intramembrane proteolysis.
    McElroy B; Powell JC; McCarthy JV
    Biochem Biophys Res Commun; 2007 Jul; 358(4):1136-41. PubMed ID: 17524361
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Presenilin/gamma-secretase-mediated cleavage of the voltage-gated sodium channel beta2-subunit regulates cell adhesion and migration.
    Kim DY; Ingano LA; Carey BW; Pettingell WH; Kovacs DM
    J Biol Chem; 2005 Jun; 280(24):23251-61. PubMed ID: 15833746
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein.
    Laudon H; Mathews PM; Karlström H; Bergman A; Farmery MR; Nixon RA; Winblad B; Gandy SE; Lendahl U; Lundkvist J; Näslund J
    J Neurochem; 2004 Apr; 89(1):44-53. PubMed ID: 15030388
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease.
    Wolfe MS; De Los Angeles J; Miller DD; Xia W; Selkoe DJ
    Biochemistry; 1999 Aug; 38(35):11223-30. PubMed ID: 10471271
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s).
    Kimberly WT; Esler WP; Ye W; Ostaszewski BL; Gao J; Diehl T; Selkoe DJ; Wolfe MS
    Biochemistry; 2003 Jan; 42(1):137-44. PubMed ID: 12515548
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Abeta42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain.
    Weggen S; Eriksen JL; Sagi SA; Pietrzik CU; Golde TE; Koo EH
    J Biol Chem; 2003 Aug; 278(33):30748-54. PubMed ID: 12777371
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Sequential and gamma-secretase-dependent processing of the betacellulin precursor generates a palmitoylated intracellular-domain fragment that inhibits cell growth.
    Stoeck A; Shang L; Dempsey PJ
    J Cell Sci; 2010 Jul; 123(Pt 13):2319-31. PubMed ID: 20530572
    [TBL] [Abstract][Full Text] [Related]  

  • 16. gamma-Secretase: a multifaceted regulator of angiogenesis.
    Boulton ME; Cai J; Grant MB
    J Cell Mol Med; 2008 Jun; 12(3):781-95. PubMed ID: 18266961
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.
    Okochi M; Steiner H; Fukumori A; Tanii H; Tomita T; Tanaka T; Iwatsubo T; Kudo T; Takeda M; Haass C
    EMBO J; 2002 Oct; 21(20):5408-16. PubMed ID: 12374741
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch.
    Chen F; Gu Y; Hasegawa H; Ruan X; Arawaka S; Fraser P; Westaway D; Mount H; St George-Hyslop P
    J Biol Chem; 2002 Sep; 277(39):36521-6. PubMed ID: 12119298
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Linking receptor-mediated endocytosis and cell signaling: evidence for regulated intramembrane proteolysis of megalin in proximal tubule.
    Zou Z; Chung B; Nguyen T; Mentone S; Thomson B; Biemesderfer D
    J Biol Chem; 2004 Aug; 279(33):34302-10. PubMed ID: 15180987
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase.
    Six E; Ndiaye D; Laabi Y; Brou C; Gupta-Rossi N; Israel A; Logeat F
    Proc Natl Acad Sci U S A; 2003 Jun; 100(13):7638-43. PubMed ID: 12794186
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.