BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

275 related articles for article (PubMed ID: 11747434)

  • 1. Conformation of the substrate and pterin cofactor bound to human tryptophan hydroxylase. Important role of Phe313 in substrate specificity.
    McKinney J; Teigen K; Frøystein NA; Salaün C; Knappskog PM; Haavik J; Martínez A
    Biochemistry; 2001 Dec; 40(51):15591-601. PubMed ID: 11747434
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The structural basis of the recognition of phenylalanine and pterin cofactors by phenylalanine hydroxylase: implications for the catalytic mechanism.
    Teigen K; Frøystein NA; Martínez A
    J Mol Biol; 1999 Dec; 294(3):807-23. PubMed ID: 10610798
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Crystal structure of tyrosine hydroxylase with bound cofactor analogue and iron at 2.3 A resolution: self-hydroxylation of Phe300 and the pterin-binding site.
    Goodwill KE; Sabatier C; Stevens RC
    Biochemistry; 1998 Sep; 37(39):13437-45. PubMed ID: 9753429
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Tetrahydrobiopterin binding to aromatic amino acid hydroxylases. Ligand recognition and specificity.
    Teigen K; Dao KK; McKinney JA; Gorren AC; Mayer B; Frøystein NA; Haavik J; Martínez A
    J Med Chem; 2004 Nov; 47(24):5962-71. PubMed ID: 15537351
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Identification of substrate orienting and phosphorylation sites within tryptophan hydroxylase using homology-based molecular modeling.
    Jiang GC; Yohrling GJ; Schmitt JD; Vrana KE
    J Mol Biol; 2000 Sep; 302(4):1005-17. PubMed ID: 10993738
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Crystal structure of tryptophan hydroxylase with bound amino acid substrate.
    Windahl MS; Petersen CR; Christensen HE; Harris P
    Biochemistry; 2008 Nov; 47(46):12087-94. PubMed ID: 18937498
    [TBL] [Abstract][Full Text] [Related]  

  • 7. High resolution crystal structures of the catalytic domain of human phenylalanine hydroxylase in its catalytically active Fe(II) form and binary complex with tetrahydrobiopterin.
    Andersen OA; Flatmark T; Hough E
    J Mol Biol; 2001 Nov; 314(2):279-91. PubMed ID: 11718561
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Crystal structure and site-specific mutagenesis of pterin-bound human phenylalanine hydroxylase.
    Erlandsen H; Bjørgo E; Flatmark T; Stevens RC
    Biochemistry; 2000 Mar; 39(9):2208-17. PubMed ID: 10694386
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Three-dimensional structure of human tryptophan hydroxylase and its implications for the biosynthesis of the neurotransmitters serotonin and melatonin.
    Wang L; Erlandsen H; Haavik J; Knappskog PM; Stevens RC
    Biochemistry; 2002 Oct; 41(42):12569-74. PubMed ID: 12379098
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Role of tryptophan hydroxylase phe313 in determining substrate specificity.
    Daubner SC; Moran GR; Fitzpatrick PF
    Biochem Biophys Res Commun; 2002 Apr; 292(3):639-41. PubMed ID: 11922614
    [TBL] [Abstract][Full Text] [Related]  

  • 11. A structural approach into human tryptophan hydroxylase and its implications for the regulation of serotonin biosynthesis.
    Martínez A; Knappskog PM; Haavik J
    Curr Med Chem; 2001 Jul; 8(9):1077-91. PubMed ID: 11472242
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Conformation and interaction of phenylalanine with the divalent cation at the active site of human recombinant tyrosine hydroxylase as determined by proton NMR.
    Martínez A; Abeygunawardana C; Haavik J; Flatmark T; Mildvan AS
    Biochemistry; 1993 Jun; 32(25):6381-90. PubMed ID: 8100148
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Crystal structure of the ternary complex of the catalytic domain of human phenylalanine hydroxylase with tetrahydrobiopterin and 3-(2-thienyl)-L-alanine, and its implications for the mechanism of catalysis and substrate activation.
    Andersen OA; Flatmark T; Hough E
    J Mol Biol; 2002 Jul; 320(5):1095-108. PubMed ID: 12126628
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Studies on the regulatory properties of the pterin cofactor and dopamine bound at the active site of human phenylalanine hydroxylase.
    Solstad T; Stokka AJ; Andersen OA; Flatmark T
    Eur J Biochem; 2003 Mar; 270(5):981-90. PubMed ID: 12603331
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Probing cofactor specificity in phenylalanine hydroxylase by molecular dynamics simulations.
    Teigen K; Martinez A
    J Biomol Struct Dyn; 2003 Jun; 20(6):733-40. PubMed ID: 12744702
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The effect of substrate, dihydrobiopterin, and dopamine on the EPR spectroscopic properties and the midpoint potential of the catalytic iron in recombinant human phenylalanine hydroxylase.
    Hagedoorn PL; Schmidt PP; Andersson KK; Hagen WR; Flatmark T; Martínez A
    J Biol Chem; 2001 Jun; 276(25):22850-6. PubMed ID: 11301319
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Isoform-Specific Substrate Inhibition Mechanism of Human Tryptophan Hydroxylase.
    Tidemand KD; Peters GH; Harris P; Stensgaard E; Christensen HEM
    Biochemistry; 2017 Nov; 56(46):6155-6164. PubMed ID: 29035515
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Modeled ligand-protein complexes elucidate the origin of substrate specificity and provide insight into catalytic mechanisms of phenylalanine hydroxylase and tyrosine hydroxylase.
    Maass A; Scholz J; Moser A
    Eur J Biochem; 2003 Mar; 270(6):1065-75. PubMed ID: 12631267
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Determinants of the substrate specificity of human cytochrome P-450 CYP2D6: design and construction of a mutant with testosterone hydroxylase activity.
    Smith G; Modi S; Pillai I; Lian LY; Sutcliffe MJ; Pritchard MP; Friedberg T; Roberts GC; Wolf CR
    Biochem J; 1998 May; 331 ( Pt 3)(Pt 3):783-92. PubMed ID: 9560305
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The regulatory domain of human tryptophan hydroxylase 1 forms a stable dimer.
    Zhang S; Hinck CS; Fitzpatrick PF
    Biochem Biophys Res Commun; 2016 Aug; 476(4):457-461. PubMed ID: 27255998
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.