BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

371 related articles for article (PubMed ID: 11774003)

  • 1. The biosynthetic gene cluster for the anticancer drug bleomycin from Streptomyces verticillus ATCC15003 as a model for hybrid peptide-polyketide natural product biosynthesis.
    Shen B; Du L; Sanchez C; Edwards DJ; Chen M; Murrell JM
    J Ind Microbiol Biotechnol; 2001 Dec; 27(6):378-85. PubMed ID: 11774003
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Cloning and characterization of the bleomycin biosynthetic gene cluster from Streptomyces verticillus ATCC15003.
    Shen B; Du L; Sanchez C; Edwards DJ; Chen M; Murrell JM
    J Nat Prod; 2002 Mar; 65(3):422-31. PubMed ID: 11908996
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The biosynthetic gene cluster for the antitumor drug bleomycin from Streptomyces verticillus ATCC15003 supporting functional interactions between nonribosomal peptide synthetases and a polyketide synthase.
    Du L; Sánchez C; Chen M; Edwards DJ; Shen B
    Chem Biol; 2000 Aug; 7(8):623-42. PubMed ID: 11048953
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Leinamycin biosynthesis revealing unprecedented architectural complexity for a hybrid polyketide synthase and nonribosomal peptide synthetase.
    Tang GL; Cheng YQ; Shen B
    Chem Biol; 2004 Jan; 11(1):33-45. PubMed ID: 15112993
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Cloning and characterization of a phosphopantetheinyl transferase from Streptomyces verticillus ATCC15003, the producer of the hybrid peptide-polyketide antitumor drug bleomycin.
    Sánchez C; Du L; Edwards DJ; Toney MD; Shen B
    Chem Biol; 2001 Jul; 8(7):725-38. PubMed ID: 11451672
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Biosynthesis of hybrid peptide-polyketide natural products.
    Du L; Shen B
    Curr Opin Drug Discov Devel; 2001 Mar; 4(2):215-28. PubMed ID: 11378961
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Hybrid peptide-polyketide natural products: biosynthesis and prospects toward engineering novel molecules.
    Du L; Sánchez C; Shen B
    Metab Eng; 2001 Jan; 3(1):78-95. PubMed ID: 11162234
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The tallysomycin biosynthetic gene cluster from Streptoalloteichus hindustanus E465-94 ATCC 31158 unveiling new insights into the biosynthesis of the bleomycin family of antitumor antibiotics.
    Tao M; Wang L; Wendt-Pienkowski E; George NP; Galm U; Zhang G; Coughlin JM; Shen B
    Mol Biosyst; 2007 Jan; 3(1):60-74. PubMed ID: 17216057
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Identification and localization of the gene cluster encoding biosynthesis of the antitumor macrolactam leinamycin in Streptomyces atroolivaceus S-140.
    Cheng YQ; Tang GL; Shen B
    J Bacteriol; 2002 Dec; 184(24):7013-24. PubMed ID: 12446651
    [TBL] [Abstract][Full Text] [Related]  

  • 10. A hybrid NRPS-PKS gene cluster related to the bleomycin family of antitumor antibiotics in Alteromonas macleodii strains.
    Mizuno CM; Kimes NE; López-Pérez M; Ausó E; Rodriguez-Valera F; Ghai R
    PLoS One; 2013; 8(9):e76021. PubMed ID: 24069455
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Characterization of biosynthetic gene cluster for the production of virginiamycin M, a streptogramin type A antibiotic, in Streptomyces virginiae.
    Pulsawat N; Kitani S; Nihira T
    Gene; 2007 May; 393(1-2):31-42. PubMed ID: 17350183
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The biosynthetic gene cluster of zorbamycin, a member of the bleomycin family of antitumor antibiotics, from Streptomyces flavoviridis ATCC 21892.
    Galm U; Wendt-Pienkowski E; Wang L; George NP; Oh TJ; Yi F; Tao M; Coughlin JM; Shen B
    Mol Biosyst; 2009 Jan; 5(1):77-90. PubMed ID: 19081934
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The phosphopantetheinyl transferase KirP activates the ACP and PCP domains of the kirromycin NRPS/PKS of Streptomyces collinus Tü 365.
    Pavlidou M; Pross EK; Musiol EM; Kulik A; Wohlleben W; Weber T
    FEMS Microbiol Lett; 2011 Jun; 319(1):26-33. PubMed ID: 21401713
    [TBL] [Abstract][Full Text] [Related]  

  • 14. A single Sfp-type phosphopantetheinyl transferase plays a major role in the biosynthesis of PKS and NRPS derived metabolites in Streptomyces ambofaciens ATCC23877.
    Bunet R; Riclea R; Laureti L; Hôtel L; Paris C; Girardet JM; Spiteller D; Dickschat JS; Leblond P; Aigle B
    PLoS One; 2014; 9(1):e87607. PubMed ID: 24498152
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Genome-wide survey of polyketide synthase and nonribosomal peptide synthetase gene clusters in Streptomyces turgidiscabies NBRC 16081.
    Komaki H; Ichikawa N; Oguchi A; Hanamaki T; Fujita N
    J Gen Appl Microbiol; 2012; 58(5):363-72. PubMed ID: 23149681
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Nonlinear Biosynthetic Assembly of Alpiniamide by a Hybrid
    Sigrist R; Luhavaya H; McKinnie SMK; Ferreira da Silva A; Jurberg ID; Moore BS; Gonzaga de Oliveira L
    ACS Chem Biol; 2020 Apr; 15(4):1067-1077. PubMed ID: 32195572
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Characterization of Miharamycin Biosynthesis Reveals a Hybrid NRPS-PKS to Synthesize High-Carbon Sugar from a Complex Nucleoside.
    Wang F; Zhang WH; Zhao J; Kang WJ; Wang S; Yu B; Pan HX; Tang GL
    J Am Chem Soc; 2020 Apr; 142(13):5996-6000. PubMed ID: 32167762
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Chain initiation in the leinamycin-producing hybrid nonribosomal peptide/polyketide synthetase from Streptomyces atroolivaceus S-140. Discrete, monofunctional adenylation enzyme and peptidyl carrier protein that directly load D-alanine.
    Tang GL; Cheng YQ; Shen B
    J Biol Chem; 2007 Jul; 282(28):20273-82. PubMed ID: 17502372
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Novel features in a combined polyketide synthase/non-ribosomal peptide synthetase: the myxalamid biosynthetic gene cluster of the myxobacterium Stigmatella aurantiaca Sga15.
    Silakowski B; Nordsiek G; Kunze B; Blöcker H; Müller R
    Chem Biol; 2001 Jan; 8(1):59-69. PubMed ID: 11182319
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Multiple hybrid polyketide synthase/non-ribosomal peptide synthetase gene clusters in the myxobacterium Stigmatella aurantiaca.
    Silakowski B; Kunze B; Müller R
    Gene; 2001 Sep; 275(2):233-40. PubMed ID: 11587850
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 19.