These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

109 related articles for article (PubMed ID: 11814808)

  • 1. [(3)H]-M-MPEP, a potent, subtype-selective radioligand for the metabotropic glutamate receptor subtype 5.
    Gasparini F; Andres H; Flor PJ; Heinrich M; Inderbitzin W; Lingenhöhl K; Müller H; Munk VC; Omilusik K; Stierlin C; Stoehr N; Vranesic I; Kuhn R
    Bioorg Med Chem Lett; 2002 Feb; 12(3):407-9. PubMed ID: 11814808
    [TBL] [Abstract][Full Text] [Related]  

  • 2. A close structural analog of 2-methyl-6-(phenylethynyl)-pyridine acts as a neutral allosteric site ligand on metabotropic glutamate receptor subtype 5 and blocks the effects of multiple allosteric modulators.
    Rodriguez AL; Nong Y; Sekaran NK; Alagille D; Tamagnan GD; Conn PJ
    Mol Pharmacol; 2005 Dec; 68(6):1793-802. PubMed ID: 16155210
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The non-competitive antagonists 2-methyl-6-(phenylethynyl)pyridine and 7-hydroxyiminocyclopropan[b]chromen-1a-carboxylic acid ethyl ester interact with overlapping binding pockets in the transmembrane region of group I metabotropic glutamate receptors.
    Pagano A; Ruegg D; Litschig S; Stoehr N; Stierlin C; Heinrich M; Floersheim P; Prezèau L; Carroll F; Pin JP; Cambria A; Vranesic I; Flor PJ; Gasparini F; Kuhn R
    J Biol Chem; 2000 Oct; 275(43):33750-8. PubMed ID: 10934211
    [TBL] [Abstract][Full Text] [Related]  

  • 4. [3H]Methoxymethyl-3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine binding to metabotropic glutamate receptor subtype 5 in rodent brain: in vitro and in vivo characterization.
    Anderson JJ; Rao SP; Rowe B; Giracello DR; Holtz G; Chapman DF; Tehrani L; Bradbury MJ; Cosford ND; Varney MA
    J Pharmacol Exp Ther; 2002 Dec; 303(3):1044-51. PubMed ID: 12438526
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Methoxyphenylethynyl, methoxypyridylethynyl and phenylethynyl derivatives of pyridine: synthesis, radiolabeling and evaluation of new PET ligands for metabotropic glutamate subtype 5 receptors.
    Yu M; Tueckmantel W; Wang X; Zhu A; Kozikowski AP; Brownell AL
    Nucl Med Biol; 2005 Aug; 32(6):631-40. PubMed ID: 16026710
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic glutamate receptor subtype 5 antagonists; search for cocaine medications.
    Iso Y; Grajkowska E; Wroblewski JT; Davis J; Goeders NE; Johnson KM; Sanker S; Roth BL; Tueckmantel W; Kozikowski AP
    J Med Chem; 2006 Feb; 49(3):1080-100. PubMed ID: 16451073
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses.
    Chen Y; Nong Y; Goudet C; Hemstapat K; de Paulis T; Pin JP; Conn PJ
    Mol Pharmacol; 2007 May; 71(5):1389-98. PubMed ID: 17303702
    [TBL] [Abstract][Full Text] [Related]  

  • 8. [3H]-methoxymethyl-MTEP and [3H]-methoxy-PEPy: potent and selective radioligands for the metabotropic glutamate subtype 5 (mGlu5) receptor.
    Cosford ND; Roppe J; Tehrani L; Schweiger EJ; Seiders TJ; Chaudary A; Rao S; Varney MA
    Bioorg Med Chem Lett; 2003 Feb; 13(3):351-4. PubMed ID: 12565928
    [TBL] [Abstract][Full Text] [Related]  

  • 9. In vivo receptor occupancy of mGlu5 receptor antagonists using the novel radioligand [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine).
    Anderson JJ; Bradbury MJ; Giracello DR; Chapman DF; Holtz G; Roppe J; King C; Cosford ND; Varney MA
    Eur J Pharmacol; 2003 Jul; 473(1):35-40. PubMed ID: 12877935
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Radiosynthesis and preclinical evaluation of 11C-ABP688 as a probe for imaging the metabotropic glutamate receptor subtype 5.
    Ametamey SM; Kessler LJ; Honer M; Wyss MT; Buck A; Hintermann S; Auberson YP; Gasparini F; Schubiger PA
    J Nucl Med; 2006 Apr; 47(4):698-705. PubMed ID: 16595505
    [TBL] [Abstract][Full Text] [Related]  

  • 11. In vitro characterization of [3H]MethoxyPyEP, an mGluR5 selective radioligand.
    Patel S; Krause SM; Hamill T; Chaudhary A; Burns DH; Gibson RA
    Life Sci; 2003 Jun; 73(3):371-9. PubMed ID: 12757844
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Potent mGluR5 antagonists: pyridyl and thiazolyl-ethynyl-3,5-disubstituted-phenyl series.
    Alagille D; DaCosta H; Chen Y; Hemstapat K; Rodriguez A; Baldwin RM; Conn PJ; Tamagnan GD
    Bioorg Med Chem Lett; 2011 Jun; 21(11):3243-7. PubMed ID: 21546249
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Mutational analysis and molecular modeling of the binding pocket of the metabotropic glutamate 5 receptor negative modulator 2-methyl-6-(phenylethynyl)-pyridine.
    Malherbe P; Kratochwil N; Zenner MT; Piussi J; Diener C; Kratzeisen C; Fischer C; Porter RH
    Mol Pharmacol; 2003 Oct; 64(4):823-32. PubMed ID: 14500738
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Evaluation of four pyridine analogs to characterize 6-OHDA-induced modulation of mGluR5 function in rat brain using microPET studies.
    Zhu A; Wang X; Yu M; Wang JQ; Brownell AL
    J Cereb Blood Flow Metab; 2007 Sep; 27(9):1623-31. PubMed ID: 17299451
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Characterisation of the actions of group I metabotropic glutamate receptor subtype selective ligands on excitatory amino acid release and sodium-dependent re-uptake in rat cerebrocortical minislices.
    Fazal A; Parker F; Palmer AM; Croucher MJ
    J Neurochem; 2003 Sep; 86(6):1346-58. PubMed ID: 12950444
    [TBL] [Abstract][Full Text] [Related]  

  • 16. In vitro and in vivo characterization of MPEP, an allosteric modulator of the metabotropic glutamate receptor subtype 5: review article.
    Kuhn R; Pagano A; Stoehr N; Vranesic I; Flor PJ; Lingenhöhl K; Spooren W; Gentsch C; Vassout A; Pilc A; Gasparini F
    Amino Acids; 2002; 23(1-3):207-11. PubMed ID: 12373539
    [TBL] [Abstract][Full Text] [Related]  

  • 17. 2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist.
    Gasparini F; Lingenhöhl K; Stoehr N; Flor PJ; Heinrich M; Vranesic I; Biollaz M; Allgeier H; Heckendorn R; Urwyler S; Varney MA; Johnson EC; Hess SD; Rao SP; Sacaan AI; Santori EM; Veliçelebi G; Kuhn R
    Neuropharmacology; 1999 Oct; 38(10):1493-503. PubMed ID: 10530811
    [TBL] [Abstract][Full Text] [Related]  

  • 18. In vitro binding of a radio-labeled positive allosteric modulator for metabotropic glutamate receptor subtype 5.
    Zysk JR; Spear N; Fieles W; Stein MM; Sygowski LS; King MM; Hoesch V; Hastings R; Brockel B; Do M; Ström P; Gadient R; Chhajlani V; Elmore CS; Maier DL
    Synapse; 2013 Mar; 67(3):135-44. PubMed ID: 23150216
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Antagonism at metabotropic glutamate 5 receptors inhibits nicotine- and cocaine-taking behaviours and prevents nicotine-triggered relapse to nicotine-seeking.
    Tessari M; Pilla M; Andreoli M; Hutcheson DM; Heidbreder CA
    Eur J Pharmacol; 2004 Sep; 499(1-2):121-33. PubMed ID: 15363959
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Radiolabeling and in vitro and in vivo evaluation of [18F]-FE-DABP688 as a PET radioligand for the metabotropic glutamate receptor subtype 5.
    Honer M; Stoffel A; Kessler LJ; Schubiger PA; Ametamey SM
    Nucl Med Biol; 2007 Nov; 34(8):973-80. PubMed ID: 17998101
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.