These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

266 related articles for article (PubMed ID: 11823456)

  • 1. Identification of novel point mutations in ERK2 that selectively disrupt binding to MEK1.
    Robinson FL; Whitehurst AW; Raman M; Cobb MH
    J Biol Chem; 2002 Apr; 277(17):14844-52. PubMed ID: 11823456
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Loss of active MEK1-ERK1/2 restores epithelial phenotype and morphogenesis in transdifferentiated MDCK cells.
    Schramek H; Feifel E; Marschitz I; Golochtchapova N; Gstraunthaler G; Montesano R
    Am J Physiol Cell Physiol; 2003 Sep; 285(3):C652-61. PubMed ID: 12900389
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The MEK1 proline-rich insert is required for efficient activation of the mitogen-activated protein kinases ERK1 and ERK2 in mammalian cells.
    Dang A; Frost JA; Cobb MH
    J Biol Chem; 1998 Jul; 273(31):19909-13. PubMed ID: 9677429
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1-ERK complexes.
    Eblen ST; Slack JK; Weber MJ; Catling AD
    Mol Cell Biol; 2002 Sep; 22(17):6023-33. PubMed ID: 12167697
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Docking sites on mitogen-activated protein kinase (MAPK) kinases, MAPK phosphatases and the Elk-1 transcription factor compete for MAPK binding and are crucial for enzymic activity.
    Bardwell AJ; Abdollahi M; Bardwell L
    Biochem J; 2003 Mar; 370(Pt 3):1077-85. PubMed ID: 12529172
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Properties of MEKs, the kinases that phosphorylate and activate the extracellular signal-regulated kinases.
    Zheng CF; Guan KL
    J Biol Chem; 1993 Nov; 268(32):23933-9. PubMed ID: 8226933
    [TBL] [Abstract][Full Text] [Related]  

  • 7. A constitutively active and nuclear form of the MAP kinase ERK2 is sufficient for neurite outgrowth and cell transformation.
    Robinson MJ; Stippec SA; Goldsmith E; White MA; Cobb MH
    Curr Biol; 1998 Oct; 8(21):1141-50. PubMed ID: 9799732
    [TBL] [Abstract][Full Text] [Related]  

  • 8. MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen-activated protein kinase.
    Xu S; Robbins D; Frost J; Dang A; Lange-Carter C; Cobb MH
    Proc Natl Acad Sci U S A; 1995 Jul; 92(15):6808-12. PubMed ID: 7624324
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Constitutively active mutant of the mitogen-activated protein kinase kinase MEK1 induces epithelial dedifferentiation and growth inhibition in madin-darby canine kidney-C7 cells.
    Schramek H; Feifel E; Healy E; Pollack V
    J Biol Chem; 1997 Apr; 272(17):11426-33. PubMed ID: 9111053
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Differential regulation of mitogen-activated protein/ERK kinase (MEK)1 and MEK2 and activation by a Ras-independent mechanism.
    Xu S; Khoo S; Dang A; Witt S; Do V; Zhen E; Schaefer EM; Cobb MH
    Mol Endocrinol; 1997 Oct; 11(11):1618-25. PubMed ID: 9328344
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The N-terminal ERK-binding site of MEK1 is required for efficient feedback phosphorylation by ERK2 in vitro and ERK activation in vivo.
    Xu Be; Wilsbacher JL; Collisson T; Cobb MH
    J Biol Chem; 1999 Nov; 274(48):34029-35. PubMed ID: 10567369
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Hydrophobic as well as charged residues in both MEK1 and ERK2 are important for their proper docking.
    Xu Be ; Stippec S; Robinson FL; Cobb MH
    J Biol Chem; 2001 Jul; 276(28):26509-15. PubMed ID: 11352917
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Selective activation of MEK1 but not MEK2 by A-Raf from epidermal growth factor-stimulated Hela cells.
    Wu X; Noh SJ; Zhou G; Dixon JE; Guan KL
    J Biol Chem; 1996 Feb; 271(6):3265-71. PubMed ID: 8621729
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Activation of extracellular signal-regulated kinases, NF-kappa B, and cyclic adenosine 5'-monophosphate response element-binding protein in lung neutrophils occurs by differing mechanisms after hemorrhage or endotoxemia.
    Abraham E; Arcaroli J; Shenkar R
    J Immunol; 2001 Jan; 166(1):522-30. PubMed ID: 11123332
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The death effector domain protein PEA-15 prevents nuclear entry of ERK2 by inhibiting required interactions.
    Whitehurst AW; Robinson FL; Moore MS; Cobb MH
    J Biol Chem; 2004 Mar; 279(13):12840-7. PubMed ID: 14707138
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A bipartite mechanism for ERK2 recognition by its cognate regulators and substrates.
    Zhang J; Zhou B; Zheng CF; Zhang ZY
    J Biol Chem; 2003 Aug; 278(32):29901-12. PubMed ID: 12754209
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Biochemical and biological functions of the N-terminal, noncatalytic domain of extracellular signal-regulated kinase 2.
    Eblen ST; Catling AD; Assanah MC; Weber MJ
    Mol Cell Biol; 2001 Jan; 21(1):249-59. PubMed ID: 11113199
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2.
    Zheng CF; Guan KL
    J Biol Chem; 1993 May; 268(15):11435-9. PubMed ID: 8388392
    [TBL] [Abstract][Full Text] [Related]  

  • 19. ERK2 shows a restrictive and locally selective mechanism of recognition by its tyrosine phosphatase inactivators not shared by its activator MEK1.
    Tárrega C; Ríos P; Cejudo-Marín R; Blanco-Aparicio C; van den Berk L; Schepens J; Hendriks W; Tabernero L; Pulido R
    J Biol Chem; 2005 Nov; 280(45):37885-94. PubMed ID: 16148006
    [TBL] [Abstract][Full Text] [Related]  

  • 20. MEK1 is required for PDGF-induced ERK activation and DNA synthesis in tracheal myocytes.
    Karpova AY; Abe MK; Li J; Liu PT; Rhee JM; Kuo WL; Hershenson MB
    Am J Physiol; 1997 Mar; 272(3 Pt 1):L558-65. PubMed ID: 9124614
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.