BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

154 related articles for article (PubMed ID: 11829470)

  • 1. 3D model of human arylamine N-acetyltransferase 2: structural basis of the slow acetylator phenotype of the R64Q variant and analysis of the active-site loop.
    Rodrigues-Lima F; Dupret JM
    Biochem Biophys Res Commun; 2002 Feb; 291(1):116-23. PubMed ID: 11829470
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Arylamine N-acetyltransferases: structural and functional implications of polymorphisms.
    Sim E; Lack N; Wang CJ; Long H; Westwood I; Fullam E; Kawamura A
    Toxicology; 2008 Dec; 254(3):170-83. PubMed ID: 18852012
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Probing the mechanism of hamster arylamine N-acetyltransferase 2 acetylation by active site modification, site-directed mutagenesis, and pre-steady state and steady state kinetic studies.
    Wang H; Vath GM; Gleason KJ; Hanna PE; Wagner CR
    Biochemistry; 2004 Jun; 43(25):8234-46. PubMed ID: 15209520
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Metabolic activation of N-hydroxyarylamines and N-hydroxyarylamides by 16 recombinant human NAT2 allozymes: effects of 7 specific NAT2 nucleic acid substitutions.
    Hein DW; Doll MA; Rustan TD; Ferguson RJ
    Cancer Res; 1995 Aug; 55(16):3531-6. PubMed ID: 7627960
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Monomorphic and polymorphic human arylamine N-acetyltransferases: a comparison of liver isozymes and expressed products of two cloned genes.
    Grant DM; Blum M; Beer M; Meyer UA
    Mol Pharmacol; 1991 Feb; 39(2):184-91. PubMed ID: 1996083
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Polymorphism p.Val231Ile alters substrate selectivity of drug-metabolizing arylamine N-acetyltransferase 2 (NAT2) isoenzyme of rhesus macaque and human.
    Tsirka T; Boukouvala S; Agianian B; Fakis G
    Gene; 2014 Feb; 536(1):65-73. PubMed ID: 24333853
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Metabolic activation of N-hydroxy-2-aminofluorene and N-hydroxy-2-acetylaminofluorene by monomorphic N-acetyltransferase (NAT1) and polymorphic N-acetyltransferase (NAT2) in colon cytosols of Syrian hamsters congenic at the NAT2 locus.
    Hein DW; Doll MA; Gray K; Rustan TD; Ferguson RJ
    Cancer Res; 1993 Feb; 53(3):509-14. PubMed ID: 8425184
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Arylamine N-acetyltransferases: characterization of the substrate specificities and molecular interactions of environmental arylamines with human NAT1 and NAT2.
    Liu L; Von Vett A; Zhang N; Walters KJ; Wagner CR; Hanna PE
    Chem Res Toxicol; 2007 Sep; 20(9):1300-8. PubMed ID: 17672512
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Catalytic mechanism of hamster arylamine N-acetyltransferase 2.
    Wang H; Liu L; Hanna PE; Wagner CR
    Biochemistry; 2005 Aug; 44(33):11295-306. PubMed ID: 16101314
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Homology modelling and structural analysis of human arylamine N-acetyltransferase NAT1: evidence for the conservation of a cysteine protease catalytic domain and an active-site loop.
    Rodrigues-Lima F; Deloménie C; Goodfellow GH; Grant DM; Dupret JM
    Biochem J; 2001 Jun; 356(Pt 2):327-34. PubMed ID: 11368758
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Cloning, sequencing, and recombinant expression of NAT1, NAT2, and NAT3 derived from the C3H/HeJ (rapid) and A/HeJ (slow) acetylator inbred mouse: functional characterization of the activation and deactivation of aromatic amine carcinogens.
    Fretland AJ; Doll MA; Gray K; Feng Y; Hein DW
    Toxicol Appl Pharmacol; 1997 Feb; 142(2):360-6. PubMed ID: 9070359
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Identification of amino acids imparting acceptor substrate selectivity to human arylamine acetyltransferases NAT1 and NAT2.
    Goodfellow GH; Dupret JM; Grant DM
    Biochem J; 2000 May; 348 Pt 1(Pt 1):159-66. PubMed ID: 10794727
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Divergence of cofactor recognition across evolution: coenzyme A binding in a prokaryotic arylamine N-acetyltransferase.
    Fullam E; Westwood IM; Anderton MC; Lowe ED; Sim E; Noble ME
    J Mol Biol; 2008 Jan; 375(1):178-91. PubMed ID: 18005984
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Construction of Syrian hamster lines congenic at the polymorphic acetyltransferase locus (NAT2): acetylator genotype-dependent N- and O-acetylation of arylamine carcinogens.
    Hein DW; Doll MA; Rustan TD; Gray K; Ferguson RJ; Feng Y
    Toxicol Appl Pharmacol; 1994 Jan; 124(1):16-24. PubMed ID: 8291057
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Insights into the o-acetylation reaction of hydroxylated heterocyclic amines by human arylamine N-acetyltransferases: a computational study.
    Lau EY; Felton JS; Lightstone FC
    Chem Res Toxicol; 2006 Sep; 19(9):1182-90. PubMed ID: 16978022
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The conserved glycine/alanine residue of the active-site loop containing the putative acetylCoA-binding motif is essential for the overall structural integrity of Mesorhizobium loti arylamine N-acetyltransferase 1.
    Atmane N; Dairou J; Flatters D; Martins M; Pluvinage B; Derreumaux P; Dupret JM; Rodrigues-Lima F
    Biochem Biophys Res Commun; 2007 Sep; 361(1):256-62. PubMed ID: 17658468
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Polymorphic expression of acetyl coenzyme A-dependent arylamine N-acetyltransferase and acetyl coenzyme A-dependent O-acetyltransferase-mediated activation of N-hydroxyarylamines by human bladder cytosol.
    Kirlin WG; Trinidad A; Yerokun T; Ogolla F; Ferguson RJ; Andrews AF; Brady PK; Hein DW
    Cancer Res; 1989 May; 49(9):2448-54. PubMed ID: 2784998
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Structure of arylamine N-acetyltransferase reveals a catalytic triad.
    Sinclair JC; Sandy J; Delgoda R; Sim E; Noble ME
    Nat Struct Biol; 2000 Jul; 7(7):560-4. PubMed ID: 10876241
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Arylamine N-acetyltransferase aggregation and constitutive ubiquitylation.
    Liu F; Zhang N; Zhou X; Hanna PE; Wagner CR; Koepp DM; Walters KJ
    J Mol Biol; 2006 Aug; 361(3):482-92. PubMed ID: 16857211
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The Bacillus anthracis arylamine N-acetyltransferase ((BACAN)NAT1) that inactivates sulfamethoxazole, reveals unusual structural features compared with the other NAT isoenzymes.
    Pluvinage B; Li de la Sierra-Gallay I; Kubiak X; Xu X; Dairou J; Dupret JM; Rodrigues-Lima F
    FEBS Lett; 2011 Dec; 585(24):3947-52. PubMed ID: 22062153
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.