178 related articles for article (PubMed ID: 11854269)
21. MMPs are less efficient than ADAMTS5 in cleaving aggrecan core protein.
Durigova M; Nagase H; Mort JS; Roughley PJ
Matrix Biol; 2011 Mar; 30(2):145-53. PubMed ID: 21055468
[TBL] [Abstract][Full Text] [Related]
22. The role of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) in a model of cartilage degradation.
Tortorella MD; Malfait AM; Deccico C; Arner E
Osteoarthritis Cartilage; 2001 Aug; 9(6):539-52. PubMed ID: 11520168
[TBL] [Abstract][Full Text] [Related]
23. Alpha2-macroglobulin is a novel substrate for ADAMTS-4 and ADAMTS-5 and represents an endogenous inhibitor of these enzymes.
Tortorella MD; Arner EC; Hills R; Easton A; Korte-Sarfaty J; Fok K; Wittwer AJ; Liu RQ; Malfait AM
J Biol Chem; 2004 Apr; 279(17):17554-61. PubMed ID: 14715656
[TBL] [Abstract][Full Text] [Related]
24. Analysis of aggrecan in human knee cartilage and synovial fluid indicates that aggrecanase (ADAMTS) activity is responsible for the catabolic turnover and loss of whole aggrecan whereas other protease activity is required for C-terminal processing in vivo.
Sandy JD; Verscharen C
Biochem J; 2001 Sep; 358(Pt 3):615-26. PubMed ID: 11535123
[TBL] [Abstract][Full Text] [Related]
25. MMP proteolysis of the human extracellular matrix protein aggrecan is mainly a process of normal turnover.
Struglics A; Hansson M
Biochem J; 2012 Sep; 446(2):213-23. PubMed ID: 22670872
[TBL] [Abstract][Full Text] [Related]
26. ADAMTS-4_v1 is a splice variant of ADAMTS-4 that is expressed as a protein in human synovium and cleaves aggrecan at the interglobular domain.
Wainwright SD; Bondeson J; Caterson B; Hughes CE
Arthritis Rheum; 2013 Nov; 65(11):2866-75. PubMed ID: 23897278
[TBL] [Abstract][Full Text] [Related]
27. Thyroid hormone enhances aggrecanase-2/ADAM-TS5 expression and proteoglycan degradation in growth plate cartilage.
Makihira S; Yan W; Murakami H; Furukawa M; Kawai T; Nikawa H; Yoshida E; Hamada T; Okada Y; Kato Y
Endocrinology; 2003 Jun; 144(6):2480-8. PubMed ID: 12746310
[TBL] [Abstract][Full Text] [Related]
28. Interleukin-1alpha treatment of meniscal explants stimulates the production and release of aggrecanase-generated, GAG-substituted aggrecan products and also the release of pre-formed, aggrecanase-generated G1 and m-calpain-generated G1-G2.
Lemke AK; Sandy JD; Voigt H; Dreier R; Lee JH; Grodzinsky AJ; Mentlein R; Fay J; Schünke M; Kurz B
Cell Tissue Res; 2010 Apr; 340(1):179-88. PubMed ID: 20217136
[TBL] [Abstract][Full Text] [Related]
29. Release of hyaluronan and hyaladherins (aggrecan G1 domain and link proteins) from articular cartilage exposed to ADAMTS-4 (aggrecanase 1) or ADAMTS-5 (aggrecanase 2).
Chockalingam PS; Zeng W; Morris EA; Flannery CR
Arthritis Rheum; 2004 Sep; 50(9):2839-48. PubMed ID: 15457452
[TBL] [Abstract][Full Text] [Related]
30. Activation of the proteolytic activity of ADAMTS4 (aggrecanase-1) by C-terminal truncation.
Gao G; Westling J; Thompson VP; Howell TD; Gottschall PE; Sandy JD
J Biol Chem; 2002 Mar; 277(13):11034-41. PubMed ID: 11796708
[TBL] [Abstract][Full Text] [Related]
31. Development of human neutralizing antibody to ADAMTS4 (aggrecanase-1) and ADAMTS5 (aggrecanase-2).
Shiraishi A; Mochizuki S; Miyakoshi A; Kojoh K; Okada Y
Biochem Biophys Res Commun; 2016 Jan; 469(1):62-69. PubMed ID: 26612259
[TBL] [Abstract][Full Text] [Related]
32. Functional differences of the catalytic and non-catalytic domains in human ADAMTS-4 and ADAMTS-5 in aggrecanolytic activity.
Fushimi K; Troeberg L; Nakamura H; Lim NH; Nagase H
J Biol Chem; 2008 Mar; 283(11):6706-16. PubMed ID: 18156631
[TBL] [Abstract][Full Text] [Related]
33. Effects of covalently attached chondroitin sulfate on aggrecan cleavage by ADAMTS-4 and MMP-13.
Miwa HE; Gerken TA; Hering TM
Matrix Biol; 2006 Oct; 25(8):534-45. PubMed ID: 16945513
[TBL] [Abstract][Full Text] [Related]
34. Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4.
Gendron C; Kashiwagi M; Lim NH; Enghild JJ; Thøgersen IB; Hughes C; Caterson B; Nagase H
J Biol Chem; 2007 Jun; 282(25):18294-18306. PubMed ID: 17430884
[TBL] [Abstract][Full Text] [Related]
35. The thrombospondin motif of aggrecanase-1 (ADAMTS-4) is critical for aggrecan substrate recognition and cleavage.
Tortorella M; Pratta M; Liu RQ; Abbaszade I; Ross H; Burn T; Arner E
J Biol Chem; 2000 Aug; 275(33):25791-7. PubMed ID: 10827174
[TBL] [Abstract][Full Text] [Related]
36. Identification of a stromelysin cleavage site within the interglobular domain of human aggrecan. Evidence for proteolysis at this site in vivo in human articular cartilage.
Flannery CR; Lark MW; Sandy JD
J Biol Chem; 1992 Jan; 267(2):1008-14. PubMed ID: 1730630
[TBL] [Abstract][Full Text] [Related]
37. Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins.
Tortorella MD; Burn TC; Pratta MA; Abbaszade I; Hollis JM; Liu R; Rosenfeld SA; Copeland RA; Decicco CP; Wynn R; Rockwell A; Yang F; Duke JL; Solomon K; George H; Bruckner R; Nagase H; Itoh Y; Ellis DM; Ross H; Wiswall BH; Murphy K; Hillman MC; Hollis GF; Newton RC; Magolda RL; Trzaskos JM; Arner EC
Science; 1999 Jun; 284(5420):1664-6. PubMed ID: 10356395
[TBL] [Abstract][Full Text] [Related]
38. ADAMTS4 (aggrecanase-1) cleaves human brain versican V2 at Glu405-Gln406 to generate glial hyaluronate binding protein.
Westling J; Gottschall PE; Thompson VP; Cockburn A; Perides G; Zimmermann DR; Sandy JD
Biochem J; 2004 Feb; 377(Pt 3):787-95. PubMed ID: 14561220
[TBL] [Abstract][Full Text] [Related]
39. TIMP-3 is a potent inhibitor of aggrecanase 1 (ADAM-TS4) and aggrecanase 2 (ADAM-TS5).
Kashiwagi M; Tortorella M; Nagase H; Brew K
J Biol Chem; 2001 Apr; 276(16):12501-4. PubMed ID: 11278243
[TBL] [Abstract][Full Text] [Related]
40. ADAMTS-5 deficiency does not block aggrecanolysis at preferred cleavage sites in the chondroitin sulfate-rich region of aggrecan.
East CJ; Stanton H; Golub SB; Rogerson FM; Fosang AJ
J Biol Chem; 2007 Mar; 282(12):8632-40. PubMed ID: 17255106
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]
