311 related articles for article (PubMed ID: 11867728)
1. Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate.
Esler WP; Kimberly WT; Ostaszewski BL; Ye W; Diehl TS; Selkoe DJ; Wolfe MS
Proc Natl Acad Sci U S A; 2002 Mar; 99(5):2720-5. PubMed ID: 11867728
[TBL] [Abstract][Full Text] [Related]
2. Nicastrin is required for assembly of presenilin/gamma-secretase complexes to mediate Notch signaling and for processing and trafficking of beta-amyloid precursor protein in mammals.
Li T; Ma G; Cai H; Price DL; Wong PC
J Neurosci; 2003 Apr; 23(8):3272-7. PubMed ID: 12716934
[TBL] [Abstract][Full Text] [Related]
3. Presenilin-1, nicastrin, amyloid precursor protein, and gamma-secretase activity are co-localized in the lysosomal membrane.
Pasternak SH; Bagshaw RD; Guiral M; Zhang S; Ackerley CA; Pak BJ; Callahan JW; Mahuran DJ
J Biol Chem; 2003 Jul; 278(29):26687-94. PubMed ID: 12736250
[TBL] [Abstract][Full Text] [Related]
4. Localization of presenilin-nicastrin complexes and gamma-secretase activity to the trans-Golgi network.
Siman R; Velji J
J Neurochem; 2003 Mar; 84(5):1143-53. PubMed ID: 12603837
[TBL] [Abstract][Full Text] [Related]
5. Gamma-secretase--intramembrane protease with a complex.
Wolfe MS
Sci Aging Knowledge Environ; 2003 Mar; 2003(11):PE7. PubMed ID: 12844518
[TBL] [Abstract][Full Text] [Related]
6. Secretase as a target for Alzheimer's disease.
Wolfe MS
Curr Top Med Chem; 2002 Apr; 2(4):371-83. PubMed ID: 11966461
[TBL] [Abstract][Full Text] [Related]
7. Gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage.
Chyung JH; Raper DM; Selkoe DJ
J Biol Chem; 2005 Feb; 280(6):4383-92. PubMed ID: 15569674
[TBL] [Abstract][Full Text] [Related]
8. Beta-amyloid secretases and beta-amloid degrading enzyme expression in lens.
Li G; Percontino L; Sun Q; Qazi AS; Frederikse PH
Mol Vis; 2003 May; 9():179-83. PubMed ID: 12740567
[TBL] [Abstract][Full Text] [Related]
9. Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex.
De Strooper B
Neuron; 2003 Apr; 38(1):9-12. PubMed ID: 12691659
[TBL] [Abstract][Full Text] [Related]
10. Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch.
Lee SF; Shah S; Li H; Yu C; Han W; Yu G
J Biol Chem; 2002 Nov; 277(47):45013-9. PubMed ID: 12297508
[TBL] [Abstract][Full Text] [Related]
11. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.
Wolfe MS; Xia W; Ostaszewski BL; Diehl TS; Kimberly WT; Selkoe DJ
Nature; 1999 Apr; 398(6727):513-7. PubMed ID: 10206644
[TBL] [Abstract][Full Text] [Related]
12. gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation.
Herreman A; Van Gassen G; Bentahir M; Nyabi O; Craessaerts K; Mueller U; Annaert W; De Strooper B
J Cell Sci; 2003 Mar; 116(Pt 6):1127-36. PubMed ID: 12584255
[TBL] [Abstract][Full Text] [Related]
13. Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1.
Li YM; Xu M; Lai MT; Huang Q; Castro JL; DiMuzio-Mower J; Harrison T; Lellis C; Nadin A; Neduvelil JG; Register RB; Sardana MK; Shearman MS; Smith AL; Shi XP; Yin KC; Shafer JA; Gardell SJ
Nature; 2000 Jun; 405(6787):689-94. PubMed ID: 10864326
[TBL] [Abstract][Full Text] [Related]
14. Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype.
Rozmahel R; Mount HT; Chen F; Nguyen V; Huang J; Erdebil S; Liauw J; Yu G; Hasegawa H; Gu Y; Song YQ; Schmidt SD; Nixon RA; Mathews PM; Bergeron C; Fraser P; Westaway D; St George-Hyslop P
Proc Natl Acad Sci U S A; 2002 Oct; 99(22):14452-7. PubMed ID: 12388777
[TBL] [Abstract][Full Text] [Related]
15. Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane.
Kaether C; Lammich S; Edbauer D; Ertl M; Rietdorf J; Capell A; Steiner H; Haass C
J Cell Biol; 2002 Aug; 158(3):551-61. PubMed ID: 12147673
[TBL] [Abstract][Full Text] [Related]
16. gamma-Secretase inhibitors as molecular probes of presenilin function.
Wolfe MS
J Mol Neurosci; 2001 Oct; 17(2):199-204. PubMed ID: 11816793
[TBL] [Abstract][Full Text] [Related]
17. Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.
Esler WP; Kimberly WT; Ostaszewski BL; Diehl TS; Moore CL; Tsai JY; Rahmati T; Xia W; Selkoe DJ; Wolfe MS
Nat Cell Biol; 2000 Jul; 2(7):428-34. PubMed ID: 10878808
[TBL] [Abstract][Full Text] [Related]
18. Presenilin endoproteolysis mediated by an aspartyl protease activity pharmacologically distinct from gamma-secretase.
Campbell WA; Reed ML; Strahle J; Wolfe MS; Xia W
J Neurochem; 2003 Jun; 85(6):1563-74. PubMed ID: 12787075
[TBL] [Abstract][Full Text] [Related]
19. Transition-state analogue gamma-secretase inhibitors stabilize a 900 kDa presenilin/nicastrin complex.
Evin G; Canterford LD; Hoke DE; Sharples RA; Culvenor JG; Masters CL
Biochemistry; 2005 Mar; 44(11):4332-41. PubMed ID: 15766262
[TBL] [Abstract][Full Text] [Related]
20. Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2.
Periz G; Fortini ME
J Neurosci Res; 2004 Aug; 77(3):309-22. PubMed ID: 15248287
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]