311 related articles for article (PubMed ID: 11867728)
21. Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2.
Kimberly WT; LaVoie MJ; Ostaszewski BL; Ye W; Wolfe MS; Selkoe DJ
Proc Natl Acad Sci U S A; 2003 May; 100(11):6382-7. PubMed ID: 12740439
[TBL] [Abstract][Full Text] [Related]
22. Toward the structure of presenilin/γ-secretase and presenilin homologs.
Wolfe MS
Biochim Biophys Acta; 2013 Dec; 1828(12):2886-97. PubMed ID: 24099007
[TBL] [Abstract][Full Text] [Related]
23. Gamma-secretase subunit composition and distribution in the presenilin wild-type and mutant mouse brain.
Siman R; Salidas S
Neuroscience; 2004; 129(3):615-28. PubMed ID: 15541883
[TBL] [Abstract][Full Text] [Related]
24. Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.
Bentahir M; Nyabi O; Verhamme J; Tolia A; Horré K; Wiltfang J; Esselmann H; De Strooper B
J Neurochem; 2006 Feb; 96(3):732-42. PubMed ID: 16405513
[TBL] [Abstract][Full Text] [Related]
25. The gamma-secretase complex: machinery for intramembrane proteolysis.
Iwatsubo T
Curr Opin Neurobiol; 2004 Jun; 14(3):379-83. PubMed ID: 15194119
[TBL] [Abstract][Full Text] [Related]
26. Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases.
Haass C; Steiner H
Trends Cell Biol; 2002 Dec; 12(12):556-62. PubMed ID: 12495843
[TBL] [Abstract][Full Text] [Related]
27. Relationship between presenilinase and gamma-secretase.
Xia W
Drug News Perspect; 2003 Mar; 16(2):69-74. PubMed ID: 12792666
[TBL] [Abstract][Full Text] [Related]
28. PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin.
Steiner H; Winkler E; Edbauer D; Prokop S; Basset G; Yamasaki A; Kostka M; Haass C
J Biol Chem; 2002 Oct; 277(42):39062-5. PubMed ID: 12198112
[TBL] [Abstract][Full Text] [Related]
29. In vitro gamma-secretase cleavage of the Alzheimer's amyloid precursor protein correlates to a subset of presenilin complexes and is inhibited by zinc.
Hoke DE; Tan JL; Ilaya NT; Culvenor JG; Smith SJ; White AR; Masters CL; Evin GM
FEBS J; 2005 Nov; 272(21):5544-57. PubMed ID: 16262694
[TBL] [Abstract][Full Text] [Related]
30. Amyloid precursor protein associates with a nicastrin-dependent docking site on the presenilin 1-gamma-secretase complex in cells demonstrated by fluorescence lifetime imaging.
Berezovska O; Ramdya P; Skoch J; Wolfe MS; Bacskai BJ; Hyman BT
J Neurosci; 2003 Jun; 23(11):4560-6. PubMed ID: 12805296
[TBL] [Abstract][Full Text] [Related]
31. Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor.
Hu Y; Ye Y; Fortini ME
Dev Cell; 2002 Jan; 2(1):69-78. PubMed ID: 11782315
[TBL] [Abstract][Full Text] [Related]
32. Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin.
Zhao G; Liu Z; Ilagan MX; Kopan R
J Neurosci; 2010 Feb; 30(5):1648-56. PubMed ID: 20130175
[TBL] [Abstract][Full Text] [Related]
33. Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin.
LaVoie MJ; Fraering PC; Ostaszewski BL; Ye W; Kimberly WT; Wolfe MS; Selkoe DJ
J Biol Chem; 2003 Sep; 278(39):37213-22. PubMed ID: 12857757
[TBL] [Abstract][Full Text] [Related]
34. In vitro characterization of the presenilin-dependent gamma-secretase complex using a novel affinity ligand.
Beher D; Fricker M; Nadin A; Clarke EE; Wrigley JD; Li YM; Culvenor JG; Masters CL; Harrison T; Shearman MS
Biochemistry; 2003 Jul; 42(27):8133-42. PubMed ID: 12846562
[TBL] [Abstract][Full Text] [Related]
35. Two domains within the first putative transmembrane domain of presenilin 1 differentially influence presenilinase and gamma-secretase activity.
Brunkan AL; Martinez M; Wang J; Walker ES; Beher D; Shearman MS; Goate AM
J Neurochem; 2005 Sep; 94(5):1315-28. PubMed ID: 16001967
[TBL] [Abstract][Full Text] [Related]
36. Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria.
Hansson CA; Frykman S; Farmery MR; Tjernberg LO; Nilsberth C; Pursglove SE; Ito A; Winblad B; Cowburn RF; Thyberg J; Ankarcrona M
J Biol Chem; 2004 Dec; 279(49):51654-60. PubMed ID: 15456764
[TBL] [Abstract][Full Text] [Related]
37. Aph-2/Nicastrin: an essential component of gamma-secretase and regulator of Notch signaling and Presenilin localization.
Kopan R; Goate A
Neuron; 2002 Jan; 33(3):321-4. PubMed ID: 11832221
[TBL] [Abstract][Full Text] [Related]
38. Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1.
Shirotani K; Edbauer D; Kostka M; Steiner H; Haass C
J Neurochem; 2004 Jun; 89(6):1520-7. PubMed ID: 15189355
[TBL] [Abstract][Full Text] [Related]
39. Active gamma-secretase complexes contain only one of each component.
Sato T; Diehl TS; Narayanan S; Funamoto S; Ihara Y; De Strooper B; Steiner H; Haass C; Wolfe MS
J Biol Chem; 2007 Nov; 282(47):33985-93. PubMed ID: 17911105
[TBL] [Abstract][Full Text] [Related]
40. TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity.
Chen F; Hasegawa H; Schmitt-Ulms G; Kawarai T; Bohm C; Katayama T; Gu Y; Sanjo N; Glista M; Rogaeva E; Wakutani Y; Pardossi-Piquard R; Ruan X; Tandon A; Checler F; Marambaud P; Hansen K; Westaway D; St George-Hyslop P; Fraser P
Nature; 2006 Apr; 440(7088):1208-12. PubMed ID: 16641999
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]