These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
60 related articles for article (PubMed ID: 11869040)
1. Expression of herpes simplex virus type 2 protein ICP10 PK rescues neurons from apoptosis due to serum deprivation or genetic defects. Perkins D; Yu Y; Bambrick LL; Yarowsky PJ; Aurelian L Exp Neurol; 2002 Mar; 174(1):118-22. PubMed ID: 11869040 [TBL] [Abstract][Full Text] [Related]
2. The herpes simplex virus type 2 R1 protein kinase (ICP10 PK) blocks apoptosis in hippocampal neurons, involving activation of the MEK/MAPK survival pathway. Perkins D; Pereira EF; Gober M; Yarowsky PJ; Aurelian L J Virol; 2002 Feb; 76(3):1435-49. PubMed ID: 11773417 [TBL] [Abstract][Full Text] [Related]
3. Growth-compromised HSV-2 vector Delta RR protects from N-methyl-D-aspartate-induced neuronal degeneration through redundant activation of the MEK/ERK and PI3-K/Akt survival pathways, either one of which overrides apoptotic cascades. Laing JM; Golembewski EK; Wales SQ; Liu J; Jafri MS; Yarowsky PJ; Aurelian L J Neurosci Res; 2008 Feb; 86(2):378-91. PubMed ID: 17893911 [TBL] [Abstract][Full Text] [Related]
4. The protein kinase activity of the large subunit of herpes simplex virus type 2 ribonucleotide reductase (ICP10) fused to the extracellular domain of the epidermal growth factor receptor is ligand-inducible. Smith CC; Luo JH; Aurelian L Virology; 1996 Mar; 217(2):425-34. PubMed ID: 8610433 [TBL] [Abstract][Full Text] [Related]
5. The transmembrane domain of the large subunit of HSV-2 ribonucleotide reductase (ICP10) is required for protein kinase activity and transformation-related signaling pathways that result in ras activation. Smith CC; Luo JH; Hunter JC; Ordonez JV; Aurelian L Virology; 1994 May; 200(2):598-612. PubMed ID: 8178446 [TBL] [Abstract][Full Text] [Related]
6. The novel protein kinase of the RR1 subunit of herpes simplex virus has autophosphorylation and transphosphorylation activity that differs in its ATP requirements for HSV-1 and HSV-2. Peng T; Hunter JR; Nelson JW Virology; 1996 Feb; 216(1):184-96. PubMed ID: 8614985 [TBL] [Abstract][Full Text] [Related]
7. The herpes simplex virus type 2 R1 protein kinase (ICP10 PK) functions as a dominant regulator of apoptosis in hippocampal neurons involving activation of the ERK survival pathway and upregulation of the antiapoptotic protein Bag-1. Perkins D; Pereira EF; Aurelian L J Virol; 2003 Jan; 77(2):1292-305. PubMed ID: 12502846 [TBL] [Abstract][Full Text] [Related]
8. A mutant type 2 herpes simplex virus deleted for the protein kinase domain of the ICP10 gene is a potent oncolytic virus. Fu X; Tao L; Cai R; Prigge J; Zhang X Mol Ther; 2006 May; 13(5):882-90. PubMed ID: 16569513 [TBL] [Abstract][Full Text] [Related]
9. The large subunit of herpes simplex virus type 2 ribonucleotide reductase (ICP10) is associated with the virion tegument and has PK activity. Smith CC; Aurelian L Virology; 1997 Aug; 234(2):235-42. PubMed ID: 9268154 [TBL] [Abstract][Full Text] [Related]
10. An HSV-2-based oncolytic virus deleted in the PK domain of the ICP10 gene is a potent inducer of apoptotic death in tumor cells. Fu X; Tao L; Zhang X Gene Ther; 2007 Aug; 14(16):1218-25. PubMed ID: 17538637 [TBL] [Abstract][Full Text] [Related]
11. Expression of the large subunit of herpes simplex virus type 2 ribonucleotide reductase (ICP10) is required for virus growth and neoplastic transformation. Smith CC; Kulka M; Wymer JP; Chung TD; Aurelian L J Gen Virol; 1992 Jun; 73 ( Pt 6)():1417-28. PubMed ID: 1318943 [TBL] [Abstract][Full Text] [Related]
12. The herpes simplex virus type 2 gene ICP10PK protects from apoptosis caused by nerve growth factor deprivation through inhibition of caspase-3 activation and XIAP up-regulation. Wales SQ; Li B; Laing JM; Aurelian L J Neurochem; 2007 Oct; 103(1):365-79. PubMed ID: 17877640 [TBL] [Abstract][Full Text] [Related]
13. A novel human gene similar to the protein kinase (PK) coding domain of the large subunit of herpes simplex virus type 2 ribonucleotide reductase (ICP10) codes for a serine-threonine PK and is expressed in melanoma cells. Smith CC; Yu YX; Kulka M; Aurelian L J Biol Chem; 2000 Aug; 275(33):25690-9. PubMed ID: 10833516 [TBL] [Abstract][Full Text] [Related]
14. Ras-GAP binding and phosphorylation by herpes simplex virus type 2 RR1 PK (ICP10) and activation of the Ras/MEK/MAPK mitogenic pathway are required for timely onset of virus growth. Smith CC; Nelson J; Aurelian L; Gober M; Goswami BB J Virol; 2000 Nov; 74(22):10417-29. PubMed ID: 11044086 [TBL] [Abstract][Full Text] [Related]
15. The growth compromised HSV-2 mutant DeltaRR prevents kainic acid-induced apoptosis and loss of function in organotypic hippocampal cultures. Gober MD; Laing JM; Thompson SM; Aurelian L Brain Res; 2006 Nov; 1119(1):26-39. PubMed ID: 17020750 [TBL] [Abstract][Full Text] [Related]
16. Stress up-regulates neuronal expression of the herpes simplex virus type 2 large subunit of ribonucleotide reductase (R1; ICP10) by activating activator protein 1. Gober MD; Wales SQ; Hunter JC; Sharma BK; Aurelian L J Neurovirol; 2005 Aug; 11(4):329-36. PubMed ID: 16162476 [TBL] [Abstract][Full Text] [Related]
17. Vaccine potential of a herpes simplex virus type 2 mutant deleted in the PK domain of the large subunit of ribonucleotide reductase (ICP10). Aurelian L; Kokuba H; Smith CC Vaccine; 1999 Apr; 17(15-16):1951-63. PubMed ID: 10217594 [TBL] [Abstract][Full Text] [Related]
18. Selenazoles (selenium compounds) facilitate survival of cultured rat pheochromocytoma PC12 cells after serum-deprivation and stimulate their neuronal differentiation via activation of Akt and mitogen-activated protein kinase, respectively. Nishina A; Sekiguchi A; Fukumoto RH; Koketsu M; Furukawa S Biochem Biophys Res Commun; 2007 Jan; 352(2):360-5. PubMed ID: 17126295 [TBL] [Abstract][Full Text] [Related]
19. The PK domain of the large subunit of herpes simplex virus type 2 ribonucleotide reductase (ICP10) is required for immediate-early gene expression and virus growth. Smith CC; Peng T; Kulka M; Aurelian L J Virol; 1998 Nov; 72(11):9131-41. PubMed ID: 9765459 [TBL] [Abstract][Full Text] [Related]
20. SHP-1 negatively regulates neuronal survival by functioning as a TrkA phosphatase. Marsh HN; Dubreuil CI; Quevedo C; Lee A; Majdan M; Walsh GS; Hausdorff S; Said FA; Zoueva O; Kozlowski M; Siminovitch K; Neel BG; Miller FD; Kaplan DR J Cell Biol; 2003 Dec; 163(5):999-1010. PubMed ID: 14662744 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]