BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

242 related articles for article (PubMed ID: 11872800)

  • 1. Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB.
    Stocker H; Andjelkovic M; Oldham S; Laffargue M; Wymann MP; Hemmings BA; Hafen E
    Science; 2002 Mar; 295(5562):2088-91. PubMed ID: 11872800
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC.
    Haas-Kogan D; Shalev N; Wong M; Mills G; Yount G; Stokoe D
    Curr Biol; 1998 Oct; 8(21):1195-8. PubMed ID: 9799739
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Evidence that SHIP-1 contributes to phosphatidylinositol 3,4,5-trisphosphate metabolism in T lymphocytes and can regulate novel phosphoinositide 3-kinase effectors.
    Freeburn RW; Wright KL; Burgess SJ; Astoul E; Cantrell DA; Ward SG
    J Immunol; 2002 Nov; 169(10):5441-50. PubMed ID: 12421919
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Regulation of phosphoinositide metabolism, Akt phosphorylation, and glucose transport by PTEN (phosphatase and tensin homolog deleted on chromosome 10) in 3T3-L1 adipocytes.
    Ono H; Katagiri H; Funaki M; Anai M; Inukai K; Fukushima Y; Sakoda H; Ogihara T; Onishi Y; Fujishiro M; Kikuchi M; Oka Y; Asano T
    Mol Endocrinol; 2001 Aug; 15(8):1411-22. PubMed ID: 11463863
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The conserved PI3'K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila.
    Scanga SE; Ruel L; Binari RC; Snow B; Stambolic V; Bouchard D; Peters M; Calvieri B; Mak TW; Woodgett JR; Manoukian AS
    Oncogene; 2000 Aug; 19(35):3971-7. PubMed ID: 10962553
    [TBL] [Abstract][Full Text] [Related]  

  • 6. DJ-1, a novel regulator of the tumor suppressor PTEN.
    Kim RH; Peters M; Jang Y; Shi W; Pintilie M; Fletcher GC; DeLuca C; Liepa J; Zhou L; Snow B; Binari RC; Manoukian AS; Bray MR; Liu FF; Tsao MS; Mak TW
    Cancer Cell; 2005 Mar; 7(3):263-73. PubMed ID: 15766664
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Nuclear PTEN-mediated growth suppression is independent of Akt down-regulation.
    Liu JL; Sheng X; Hortobagyi ZK; Mao Z; Gallick GE; Yung WK
    Mol Cell Biol; 2005 Jul; 25(14):6211-24. PubMed ID: 15988030
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Inhibition of ILK in PTEN-mutant human glioblastomas inhibits PKB/Akt activation, induces apoptosis, and delays tumor growth.
    Edwards LA; Thiessen B; Dragowska WH; Daynard T; Bally MB; Dedhar S
    Oncogene; 2005 May; 24(22):3596-605. PubMed ID: 15782140
    [TBL] [Abstract][Full Text] [Related]  

  • 9. PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway.
    Sun H; Lesche R; Li DM; Liliental J; Zhang H; Gao J; Gavrilova N; Mueller B; Liu X; Wu H
    Proc Natl Acad Sci U S A; 1999 May; 96(11):6199-204. PubMed ID: 10339565
    [TBL] [Abstract][Full Text] [Related]  

  • 10. 5' phospholipid phosphatase SHIP-2 causes protein kinase B inactivation and cell cycle arrest in glioblastoma cells.
    Taylor V; Wong M; Brandts C; Reilly L; Dean NM; Cowsert LM; Moodie S; Stokoe D
    Mol Cell Biol; 2000 Sep; 20(18):6860-71. PubMed ID: 10958682
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Signaling from Akt to FRAP/TOR targets both 4E-BP and S6K in Drosophila melanogaster.
    Miron M; Lasko P; Sonenberg N
    Mol Cell Biol; 2003 Dec; 23(24):9117-26. PubMed ID: 14645523
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation.
    Shan X; Czar MJ; Bunnell SC; Liu P; Liu Y; Schwartzberg PL; Wange RL
    Mol Cell Biol; 2000 Sep; 20(18):6945-57. PubMed ID: 10958690
    [TBL] [Abstract][Full Text] [Related]  

  • 13. PTEN augments staurosporine-induced apoptosis in PTEN-null Ishikawa cells by downregulating PI3K/Akt signaling pathway.
    Wan X; Yokoyama Y; Shinohara A; Takahashi Y; Tamaya T
    Cell Death Differ; 2002 Apr; 9(4):414-20. PubMed ID: 11965494
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Akt regulates COX-2 mRNA and protein expression in mutated-PTEN human endometrial cancer cells.
    St-Germain ME; Gagnon V; Mathieu I; Parent S; Asselin E
    Int J Oncol; 2004 May; 24(5):1311-24. PubMed ID: 15067356
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Drosophila PTEN regulates cell growth and proliferation through PI3K-dependent and -independent pathways.
    Gao X; Neufeld TP; Pan D
    Dev Biol; 2000 May; 221(2):404-18. PubMed ID: 10790335
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Simultaneous suppression of Erk and Akt/PKB activation by a Gab1 pleckstrin homology (PH) domain decoy.
    Ren Y; Wu J
    Anticancer Res; 2003; 23(4):3231-6. PubMed ID: 12926057
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Expression of PTEN in PTEN-deficient multiple myeloma cells abolishes tumor growth in vivo.
    Ge NL; Rudikoff S
    Oncogene; 2000 Aug; 19(36):4091-5. PubMed ID: 10962569
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway.
    Ogg S; Ruvkun G
    Mol Cell; 1998 Dec; 2(6):887-93. PubMed ID: 9885576
    [TBL] [Abstract][Full Text] [Related]  

  • 19. PTEN, but not SHIP and SHIP2, suppresses the PI3K/Akt pathway and induces growth inhibition and apoptosis of myeloma cells.
    Choi Y; Zhang J; Murga C; Yu H; Koller E; Monia BP; Gutkind JS; Li W
    Oncogene; 2002 Aug; 21(34):5289-300. PubMed ID: 12149650
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway.
    Ramaswamy S; Nakamura N; Vazquez F; Batt DB; Perera S; Roberts TM; Sellers WR
    Proc Natl Acad Sci U S A; 1999 Mar; 96(5):2110-5. PubMed ID: 10051603
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.