122 related articles for article (PubMed ID: 11886818)
21. Selection of S18326 as a new potent and selective boronic acid direct thrombin inhibitor.
Rupin A; Mennecier P; Lila C; de Nanteuil G; Verbeuren TJ
Thromb Haemost; 1997 Oct; 78(4):1221-7. PubMed ID: 9364988
[TBL] [Abstract][Full Text] [Related]
22. Microscale Parallel Synthesis of Acylated Aminotriazoles Enabling the Development of Factor XIIa and Thrombin Inhibitors.
Platte S; Korff M; Imberg L; Balicioglu I; Erbacher C; Will JM; Daniliuc CG; Karst U; Kalinin DV
ChemMedChem; 2021 Dec; 16(24):3672-3690. PubMed ID: 34278727
[TBL] [Abstract][Full Text] [Related]
23. From natural products to achiral drug prototypes: potent thrombin inhibitors based on P2/P3 dihydropyrid-2-one core motifs.
Hanessian S; Therrien E; Zhang J; Otterlo Wv; Xue Y; Gustafsson D; Nilsson I; Fjellström O
Bioorg Med Chem Lett; 2009 Sep; 19(18):5429-32. PubMed ID: 19674897
[TBL] [Abstract][Full Text] [Related]
24. Retro-binding thrombin active site inhibitors: identification of an orally active inhibitor of thrombin catalytic activity.
Iwanowicz EJ; Kimball SD; Lin J; Lau W; Han WC; Wang TC; Roberts DG; Schumacher WA; Ogletree ML; Seiler SM
Bioorg Med Chem Lett; 2002 Nov; 12(21):3183-6. PubMed ID: 12372529
[TBL] [Abstract][Full Text] [Related]
25. Oxyguanidines. Part 2: Discovery of a novel orally active thrombin inhibitor through structure-based drug design and parallel synthesis.
Lu T; Markotan T; Coppo F; Tomczuk B; Crysler C; Eisennagel S; Spurlino J; Gremminger L; Soll RM; Giardino EC; Bone R
Bioorg Med Chem Lett; 2004 Jul; 14(14):3727-31. PubMed ID: 15203151
[TBL] [Abstract][Full Text] [Related]
26. Molecular design and characterization of an alpha-thrombin inhibitor containing a novel P1 moiety.
Malikayil JA; Burkhart JP; Schreuder HA; Broersma RJ; Tardif C; Kutcher LW; Mehdi S; Schatzman GL; Neises B; Peet NP
Biochemistry; 1997 Feb; 36(5):1034-40. PubMed ID: 9033393
[TBL] [Abstract][Full Text] [Related]
27. Poststatin, a new inhibitor of prolyl endopeptidase. VII. N-cycloalkylamide analogues.
Tsuda M; Muraoka Y; Nagai M; Aoyagi T; Takeuchi T
J Antibiot (Tokyo); 1996 Sep; 49(9):909-20. PubMed ID: 8931725
[TBL] [Abstract][Full Text] [Related]
28. Peptides and pseudopeptides incorporating D-Phe-Pro-Arg and Arg-Gly-Asp lead sequences as potential antithrombotic agents.
Ilas J; Hudecz F; Süli-Vargha H; Kikelj D
J Pept Sci; 2008 Aug; 14(8):946-53. PubMed ID: 18383437
[TBL] [Abstract][Full Text] [Related]
29. 1,2-Disubstituted indole, azaindole and benzimidazole derivatives possessing amine moiety: a novel series of thrombin inhibitors.
Takeuchi K; Bastian JA; Gifford-Moore DS; Harper RW; Miller SC; Mullaney JT; Sall DJ; Smith GF; Zhang M; Fisher MJ
Bioorg Med Chem Lett; 2000 Oct; 10(20):2347-51. PubMed ID: 11055353
[TBL] [Abstract][Full Text] [Related]
30. In vitro and in vivo activities of oligodeoxynucleotide-based thrombin inhibitors containing neutral formacetal linkages.
He GX; Williams JP; Postich MJ; Swaminathan S; Shea RG; Terhorst T; Law VS; Mao CT; Sueoka C; Coutré S; Bischofberger N
J Med Chem; 1998 Oct; 41(22):4224-31. PubMed ID: 9784097
[TBL] [Abstract][Full Text] [Related]
31. Crystallization and preliminary crystallographic characterization of three peptidic inhibitors in complex with α-thrombin.
Carvalho Figueiredo A; Clement CC; Philipp M; Barbosa Pereira PJ
Acta Crystallogr Sect F Struct Biol Cryst Commun; 2011 Jan; 67(Pt 1):54-8. PubMed ID: 21206024
[TBL] [Abstract][Full Text] [Related]
32. Compounds binding to the S2-S3 pockets of thrombin.
Nilsson M; Hämäläinen M; Ivarsson M; Gottfries J; Xue Y; Hansson S; Isaksson R; Fex T
J Med Chem; 2009 May; 52(9):2708-15. PubMed ID: 19371038
[TBL] [Abstract][Full Text] [Related]
33. Inhibition of human neutrophil elastase. 4. Design, synthesis, X-ray crystallographic analysis, and structure-activity relationships for a series of P2-modified, orally active peptidyl pentafluoroethyl ketones.
Cregge RJ; Durham SL; Farr RA; Gallion SL; Hare CM; Hoffman RV; Janusz MJ; Kim HO; Koehl JR; Mehdi S; Metz WA; Peet NP; Pelton JT; Schreuder HA; Sunder S; Tardif C
J Med Chem; 1998 Jul; 41(14):2461-80. PubMed ID: 9651152
[TBL] [Abstract][Full Text] [Related]
34. Synthesis and in vitro biological evaluation of aryl boronic acids as potential inhibitors of factor XIa.
Lazarova TI; Jin L; Rynkiewicz M; Gorga JC; Bibbins F; Meyers HV; Babine R; Strickler J
Bioorg Med Chem Lett; 2006 Oct; 16(19):5022-7. PubMed ID: 16876411
[TBL] [Abstract][Full Text] [Related]
35. A cyclopent-2-enecarbonyl group mimics proline at the P2 position of prolyl oligopeptidase inhibitors.
Jarho EM; Venäläinen JI; Huuskonen J; Christiaans JA; Garcia-Horsman JA; Forsberg MM; Järvinen T; Gynther J; Männistö PT; Wallén EA
J Med Chem; 2004 Nov; 47(23):5605-7. PubMed ID: 15509157
[TBL] [Abstract][Full Text] [Related]
36. Novel potent hepatitis C virus NS3 serine protease inhibitors derived from proline-based macrocycles.
Chen KX; Njoroge FG; Arasappan A; Venkatraman S; Vibulbhan B; Yang W; Parekh TN; Pichardo J; Prongay A; Cheng KC; Butkiewicz N; Yao N; Madison V; Girijavallabhan V
J Med Chem; 2006 Feb; 49(3):995-1005. PubMed ID: 16451065
[TBL] [Abstract][Full Text] [Related]
37. Design of P1' and P3' residues of trivalent thrombin inhibitors and their crystal structures.
Slon-Usakiewicz JJ; Sivaraman J; Li Y; Cygler M; Konishi Y
Biochemistry; 2000 Mar; 39(9):2384-91. PubMed ID: 10694407
[TBL] [Abstract][Full Text] [Related]
38. D-Phe-Pro-Arg type thrombin inhibitors: unexpected selectivity by modification of the P1 moiety.
Lange UE; Baucke D; Hornberger W; Mack H; Seitz W; Höffken HW
Bioorg Med Chem Lett; 2003 Jun; 13(12):2029-33. PubMed ID: 12781189
[TBL] [Abstract][Full Text] [Related]
39. Design and synthesis of novel biologically active thrombin receptor non-peptide mimetics based on the pharmacophoric cluster Phe/Arg/NH2 of the Ser42-Phe-Leu-Leu-Arg46 motif sequence: platelet aggregation and relaxant activities.
Alexopoulos K; Fatseas P; Melissari E; Vlahakos D; Roumelioti P; Mavromoustakos T; Mihailescu S; Paredes-Carbajal MC; Mascher D; Matsoukas J
J Med Chem; 2004 Jun; 47(13):3338-52. PubMed ID: 15189031
[TBL] [Abstract][Full Text] [Related]
40. Amino acids and peptides. XVIII. Synthetic peptides related to N-terminal portion of fibrin alpha-chain and their inhibitory effect on fibrinogen/thrombin clotting.
Kawasaki K; Miyano M; Hirase K; Iwamoto M
Chem Pharm Bull (Tokyo); 1993 May; 41(5):975-7. PubMed ID: 8339344
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]
