These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

108 related articles for article (PubMed ID: 11905990)

  • 1. Neurotoxic mechanisms triggered by Alzheimer's disease-linked mutant M146L presenilin 1: involvement of NO synthase via a novel pertussis toxin target.
    Hashimoto Y; Ito Y; Arakawa E; Kita Y; Terashita K; Niikura T; Nishimoto I
    J Neurochem; 2002 Feb; 80(3):426-37. PubMed ID: 11905990
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Neurotoxic mechanisms by Alzheimer's disease-linked N141I mutant presenilin 2.
    Hashimoto Y; Niikura T; Ito Y; Kita Y; Terashita K; Nishimoto I
    J Pharmacol Exp Ther; 2002 Mar; 300(3):736-45. PubMed ID: 11861776
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Amino- and carboxyl-terminal mutants of presenilin 1 cause neuronal cell death through distinct toxic mechanisms: Study of 27 different presenilin 1 mutants.
    Hashimoto Y; Tsukamoto E; Niikura T; Yamagishi Y; Ishizaka M; Aiso S; Takashima A; Nishimoto I
    J Neurosci Res; 2004 Feb; 75(3):417-28. PubMed ID: 14743455
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Cytotoxic mechanisms by M239V presenilin 2, a little-analyzed Alzheimer's disease-causative mutant.
    Abe Y; Hashimoto Y; Tomita Y; Terashita K; Aiso S; Tajima H; Niikura T; Matsuoka M; Nishimoto I
    J Neurosci Res; 2004 Aug; 77(4):583-95. PubMed ID: 15264228
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Neurons overexpressing mutant presenilin-1 are more sensitive to apoptosis induced by endoplasmic reticulum-Golgi stress.
    Terro F; Czech C; Esclaire F; Elyaman W; Yardin C; Baclet MC; Touchet N; Tremp G; Pradier L; Hugon J
    J Neurosci Res; 2002 Aug; 69(4):530-9. PubMed ID: 12210846
    [TBL] [Abstract][Full Text] [Related]  

  • 6. V642I APP-inducible neuronal cells: a model system for investigating Alzheimer's disorders.
    Niikura T; Murayama N; Hashimoto Y; Ito Y; Yamagishi Y; Matsuoka M; Takeuchi Y; Aiso S; Nishimoto I
    Biochem Biophys Res Commun; 2000 Aug; 274(2):445-54. PubMed ID: 10913358
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Neuropathology of mice carrying mutant APP(swe) and/or PS1(M146L) transgenes: alterations in the p75(NTR) cholinergic basal forebrain septohippocampal pathway.
    Jaffar S; Counts SE; Ma SY; Dadko E; Gordon MN; Morgan D; Mufson EJ
    Exp Neurol; 2001 Aug; 170(2):227-43. PubMed ID: 11476589
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Presenilin-1-deficient neurons are nitric oxide-dependently killed by hydrogen peroxide in vitro.
    Nakajima M; Shirasawa T
    Neuroscience; 2004; 125(3):563-8. PubMed ID: 15099670
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Proteasome inhibitors prevent the degradation of familial Alzheimer's disease-linked presenilin 1 and potentiate A beta 42 recovery from human cells.
    Marambaud P; Ancolio K; Lopez-Perez E; Checler F
    Mol Med; 1998 Mar; 4(3):147-57. PubMed ID: 9562973
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Implications of presenilin 1 mutations in Alzheimer's disease.
    Komano H; Sudoh S; Kawamura Y; Wang R; Yanagisawa K
    Mech Ageing Dev; 1999 Mar; 107(3):281-98. PubMed ID: 10360683
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Processing of wild-type and mutant familial Alzheimer's disease-associated presenilin-1 in cultured neurons.
    Weihl CC; Ghadge GD; Miller RJ; Roos RP
    J Neurochem; 1999 Jul; 73(1):31-40. PubMed ID: 10386952
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Expression of a familial Alzheimer's disease-linked presenilin-1 variant enhances perforant pathway lesion-induced neuronal loss in the entorhinal cortex.
    Lazarov O; Peterson LD; Peterson DA; Sisodia SS
    J Neurosci; 2006 Jan; 26(2):429-34. PubMed ID: 16407539
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Effect of PS1 deficiency and an APP gamma-secretase inhibitor on Notch1 signaling in primary mammalian neurons.
    Jack C; Berezovska O; Wolfe MS; Hyman BT
    Brain Res Mol Brain Res; 2001 Mar; 87(2):166-74. PubMed ID: 11245918
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo.
    Borchelt DR; Thinakaran G; Eckman CB; Lee MK; Davenport F; Ratovitsky T; Prada CM; Kim G; Seekins S; Yager D; Slunt HH; Wang R; Seeger M; Levey AI; Gandy SE; Copeland NG; Jenkins NA; Price DL; Younkin SG; Sisodia SS
    Neuron; 1996 Nov; 17(5):1005-13. PubMed ID: 8938131
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Antibody-regulated neurotoxic function of cell-surface beta-amyloid precursor protein.
    Sudo H; Jiang H; Yasukawa T; Hashimoto Y; Niikura T; Kawasumi M; Matsuda S; Takeuchi Y; Aiso S; Matsuoka M; Murayama Y; Nishimoto I
    Mol Cell Neurosci; 2000 Dec; 16(6):708-23. PubMed ID: 11124892
    [TBL] [Abstract][Full Text] [Related]  

  • 16. FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex.
    Xia W; Ostaszewski BL; Kimberly WT; Rahmati T; Moore CL; Wolfe MS; Selkoe DJ
    Neurobiol Dis; 2000 Dec; 7(6 Pt B):673-81. PubMed ID: 11114265
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Presenilin 1 mutations linked to familial Alzheimer's disease increase the intracellular levels of amyloid beta-protein 1-42 and its N-terminally truncated variant(s) which are generated at distinct sites.
    Sudoh S; Kawamura Y; Sato S; Wang R; Saido TC; Oyama F; Sakaki Y; Komano H; Yanagisawa K
    J Neurochem; 1998 Oct; 71(4):1535-43. PubMed ID: 9751187
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Developmental expression of wild-type and mutant presenilin-1 in hippocampal neurons from transgenic mice: evidence for novel species-specific properties of human presenilin-1.
    Lévesque L; Annaert W; Craessaerts K; Mathews PM; Seeger M; Nixon RA; Van Leuven F; Gandy S; Westaway D; St George-Hyslop P; De Strooper B; Fraser PE
    Mol Med; 1999 Aug; 5(8):542-54. PubMed ID: 10501657
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Presenilin-1 mutations associated with familial Alzheimer's disease do not disrupt protein transport from the endoplasmic reticulum to the Golgi apparatus.
    Tan Y; Hong J; Doan T; McConlogue L; Maltese WA
    Biochim Biophys Acta; 1998 Jul; 1407(1):69-78. PubMed ID: 9639678
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Multiple mechanisms underlie neurotoxicity by different types of Alzheimer's disease mutations of amyloid precursor protein.
    Hashimoto Y; Niikura T; Ito Y; Nishimoto I
    J Biol Chem; 2000 Nov; 275(44):34541-51. PubMed ID: 10934205
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.