132 related articles for article (PubMed ID: 11914638)
1. Nucleoside transport inhibitors, dipyridamole and p-nitrobenzylthioinosine, selectively potentiate the antitumor activity of NB1011.
Boyer CR; Karjian PL; Wahl GM; Pegram M; Neuteboom ST
Anticancer Drugs; 2002 Jan; 13(1):29-36. PubMed ID: 11914638
[TBL] [Abstract][Full Text] [Related]
2. Inhibition of cell growth by NB1011 requires high thymidylate synthase levels and correlates with p53, p21, bax, and GADD45 induction.
Neuteboom ST; Karjian PL; Boyer CR; Beryt M; Pegram M; Wahl GM; Shepard HM
Mol Cancer Ther; 2002 Apr; 1(6):377-84. PubMed ID: 12477050
[TBL] [Abstract][Full Text] [Related]
3. A novel approach to thymidylate synthase as a target for cancer chemotherapy.
Li Q; Boyer C; Lee JY; Shepard HM
Mol Pharmacol; 2001 Mar; 59(3):446-52. PubMed ID: 11179438
[TBL] [Abstract][Full Text] [Related]
4. NB1011 induces Ser15 phosphorylation of p53 and activates the G2/M checkpoint.
Dellinger RW; Karjian PL; Neuteboom ST
Anticancer Drugs; 2003 Jul; 14(6):449-55. PubMed ID: 12853888
[TBL] [Abstract][Full Text] [Related]
5. Cellular transformation of the investigational new anticancer drug NB1011, a phosphoramidate of 5-(2-bromovinyl)-2'-deoxyuridine, results in modification of cellular proteins not DNA.
Sergeeva MV; Cathers BE
Biochem Pharmacol; 2003 Mar; 65(5):823-31. PubMed ID: 12628478
[TBL] [Abstract][Full Text] [Related]
6. Enzyme-catalyzed therapeutic agent (ECTA) design: activation of the antitumor ECTA compound NB1011 by thymidylate synthase.
Lackey DB; Groziak MP; Sergeeva M; Beryt M; Boyer C; Stroud RM; Sayre P; Park JW; Johnston P; Slamon D; Shepard HM; Pegram M
Biochem Pharmacol; 2001 Jan; 61(2):179-89. PubMed ID: 11163332
[TBL] [Abstract][Full Text] [Related]
7. Kinetic properties of human thymidylate synthase, an anticancer drug target.
Sergeeva OA; Khambatta HG; Cathers BE; Sergeeva MV
Biochem Biophys Res Commun; 2003 Jul; 307(2):297-300. PubMed ID: 12859954
[TBL] [Abstract][Full Text] [Related]
8. Thymidylate synthase level as the main predictive parameter for sensitivity to 5-fluorouracil, but not for folate-based thymidylate synthase inhibitors, in 13 nonselected colon cancer cell lines.
van Triest B; Pinedo HM; van Hensbergen Y; Smid K; Telleman F; Schoenmakers PS; van der Wilt CL; van Laar JA; Noordhuis P; Jansen G; Peters GJ
Clin Cancer Res; 1999 Mar; 5(3):643-54. PubMed ID: 10100718
[TBL] [Abstract][Full Text] [Related]
9. Mechanisms of acquired chemoresistance to 5-fluorouracil and tomudex: thymidylate synthase dependent and independent networks.
Wang W; McLeod HL; Cassidy J; Collie-Duguid ES
Cancer Chemother Pharmacol; 2007 May; 59(6):839-45. PubMed ID: 17119966
[TBL] [Abstract][Full Text] [Related]
10. Induction of thymidylate synthase associated with multidrug resistance in human breast and colon cancer cell lines.
Chu E; Drake JC; Koeller DM; Zinn S; Jamis-Dow CA; Yeh GC; Allegra CJ
Mol Pharmacol; 1991 Feb; 39(2):136-43. PubMed ID: 1704999
[TBL] [Abstract][Full Text] [Related]
11. 5-fluorouracil-based chemotherapy enhances the antitumor activity of a thymidylate synthase-directed polyepitopic peptide vaccine.
Correale P; Del Vecchio MT; Di Genova G; Savellini GG; La Placa M; Terrosi C; Vestri M; Urso R; Lemonnier F; Aquino A; Bonmassar E; Giorgi G; Francini G; Cusi MG
J Natl Cancer Inst; 2005 Oct; 97(19):1437-45. PubMed ID: 16204693
[TBL] [Abstract][Full Text] [Related]
12. Potentiation of the cytotoxicity of thymidylate synthase (TS) inhibitors by dipyridamole analogues with reduced alpha1-acid glycoprotein binding.
Curtin NJ; Bowman KJ; Turner RN; Huang B; Loughlin PJ; Calvert AH; Golding BT; Griffin RJ; Newell DR
Br J Cancer; 1999 Aug; 80(11):1738-46. PubMed ID: 10468290
[TBL] [Abstract][Full Text] [Related]
13. Nucleoside transport in normal and neoplastic cells.
Belt JA; Marina NM; Phelps DA; Crawford CR
Adv Enzyme Regul; 1993; 33():235-52. PubMed ID: 8356910
[TBL] [Abstract][Full Text] [Related]
14. Antitumor activity of oxaliplatin in combination with 5-fluorouracil and the thymidylate synthase inhibitor AG337 in human colon, breast and ovarian cancers.
Raymond E; Buquet-Fagot C; Djelloul S; Mester J; Cvitkovic E; Allain P; Louvet C; Gespach C
Anticancer Drugs; 1997 Oct; 8(9):876-85. PubMed ID: 9402315
[TBL] [Abstract][Full Text] [Related]
15. Glycine 154 of the equilibrative nucleoside transporter, hENT1, is important for nucleoside transport and for conferring sensitivity to the inhibitors nitrobenzylthioinosine, dipyridamole, and dilazep.
SenGupta DJ; Unadkat JD
Biochem Pharmacol; 2004 Feb; 67(3):453-8. PubMed ID: 15037197
[TBL] [Abstract][Full Text] [Related]
16. Immunological quantitation of thymidylate synthase using the monoclonal antibody TS 106 in 5-fluorouracil-sensitive and -resistant human cancer cell lines.
Johnston PG; Drake JC; Trepel J; Allegra CJ
Cancer Res; 1992 Aug; 52(16):4306-12. PubMed ID: 1643628
[TBL] [Abstract][Full Text] [Related]
17. Functional nucleoside transporters are required for gemcitabine influx and manifestation of toxicity in cancer cell lines.
Mackey JR; Mani RS; Selner M; Mowles D; Young JD; Belt JA; Crawford CR; Cass CE
Cancer Res; 1998 Oct; 58(19):4349-57. PubMed ID: 9766663
[TBL] [Abstract][Full Text] [Related]
18. Enhancement of retention and cytotoxicity of 2-chlorodeoxyadenosine in cultured human leukemic lymphoblasts by nitrobenzylthioinosine, an inhibitor of equilibrative nucleoside transport.
Wright AM; Gati WP; Paterson AR
Leukemia; 2000 Jan; 14(1):52-60. PubMed ID: 10637477
[TBL] [Abstract][Full Text] [Related]
19. Folate depletion increases sensitivity of solid tumor cell lines to 5-fluorouracil and antifolates.
Backus HH; Pinedo HM; Wouters D; Padrón JM; Molders N; van Der Wilt CL; van Groeningen CJ; Jansen G; Peters GJ
Int J Cancer; 2000 Sep; 87(6):771-8. PubMed ID: 10956384
[TBL] [Abstract][Full Text] [Related]
20. A comparison of the abilities of nitrobenzylthioinosine, dilazep, and dipyridamole to protect human hematopoietic cells from 7-deazaadenosine (tubercidin).
Cass CE; King KM; Montaño JT; Janowska-Wieczorek A
Cancer Res; 1992 Nov; 52(21):5879-86. PubMed ID: 1394215
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
