BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

173 related articles for article (PubMed ID: 11935210)

  • 1. Triclosan inhibits enoyl-reductase of type I fatty acid synthase in vitro and is cytotoxic to MCF-7 and SKBr-3 breast cancer cells.
    Liu B; Wang Y; Fillgrove KL; Anderson VE
    Cancer Chemother Pharmacol; 2002 Mar; 49(3):187-93. PubMed ID: 11935210
    [TBL] [Abstract][Full Text] [Related]  

  • 2. [Inhibition of triclosan to fatty acid synthase from goose uropygial glands and human breast cancer cells in vitro].
    Wang YQ; Lai BS; Anderson VE
    Ai Zheng; 2003 Mar; 22(3):270-3. PubMed ID: 12654184
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Novel signaling molecules implicated in tumor-associated fatty acid synthase-dependent breast cancer cell proliferation and survival: Role of exogenous dietary fatty acids, p53-p21WAF1/CIP1, ERK1/2 MAPK, p27KIP1, BRCA1, and NF-kappaB.
    Menendez JA; Mehmi I; Atlas E; Colomer R; Lupu R
    Int J Oncol; 2004 Mar; 24(3):591-608. PubMed ID: 14767544
    [TBL] [Abstract][Full Text] [Related]  

  • 4. RNA interference-mediated silencing of the p53 tumor-suppressor protein drastically increases apoptosis after inhibition of endogenous fatty acid metabolism in breast cancer cells.
    Menendez JA; Lupu R
    Int J Mol Med; 2005 Jan; 15(1):33-40. PubMed ID: 15583825
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts.
    Pizer ES; Thupari J; Han WF; Pinn ML; Chrest FJ; Frehywot GL; Townsend CA; Kuhajda FP
    Cancer Res; 2000 Jan; 60(2):213-8. PubMed ID: 10667561
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Kinetic determinants of the interaction of enoyl-ACP reductase from Plasmodium falciparum with its substrates and inhibitors.
    Kapoor M; Dar MJ; Surolia A; Surolia N
    Biochem Biophys Res Commun; 2001 Dec; 289(4):832-7. PubMed ID: 11735121
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Inhibition of Fatty Acid Synthase (FASN) synergistically enhances the efficacy of 5-fluorouracil in breast carcinoma cells.
    Vazquez-Martin A; Ropero S; Brunet J; Colomer R; Menendez JA
    Oncol Rep; 2007 Oct; 18(4):973-80. PubMed ID: 17786362
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Overexpression and hyperactivity of breast cancer-associated fatty acid synthase (oncogenic antigen-519) is insensitive to normal arachidonic fatty acid-induced suppression in lipogenic tissues but it is selectively inhibited by tumoricidal alpha-linolenic and gamma-linolenic fatty acids: a novel mechanism by which dietary fat can alter mammary tumorigenesis.
    Menendez JA; Ropero S; Mehmi I; Atlas E; Colomer R; Lupu R
    Int J Oncol; 2004 Jun; 24(6):1369-83. PubMed ID: 15138577
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Fatty acid synthase inhibition in human breast cancer cells leads to malonyl-CoA-induced inhibition of fatty acid oxidation and cytotoxicity.
    Thupari JN; Pinn ML; Kuhajda FP
    Biochem Biophys Res Commun; 2001 Jul; 285(2):217-23. PubMed ID: 11444828
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The estrogenic activity of synthetic progestins used in oral contraceptives enhances fatty acid synthase-dependent breast cancer cell proliferation and survival.
    Menendez JA; Oza BP; Colomer R; Lupu R
    Int J Oncol; 2005 Jun; 26(6):1507-15. PubMed ID: 15870863
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Characterization of the beta-carbon processing reactions of the mammalian cytosolic fatty acid synthase: role of the central core.
    Witkowski A; Joshi AK; Smith S
    Biochemistry; 2004 Aug; 43(32):10458-66. PubMed ID: 15301544
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structural basis for triclosan and NAD binding to enoyl-ACP reductase of Plasmodium falciparum.
    Suguna K; Surolia A; Surolia N
    Biochem Biophys Res Commun; 2001 Apr; 283(1):224-8. PubMed ID: 11322792
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Characterization of the inactivation of rat fatty acid synthase by C75: inhibition of partial reactions and protection by substrates.
    Rendina AR; Cheng D
    Biochem J; 2005 Jun; 388(Pt 3):895-903. PubMed ID: 15715522
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Inhibition of fatty acid synthase-dependent neoplastic lipogenesis as the mechanism of gamma-linolenic acid-induced toxicity to tumor cells: an extension to Nwankwo's hypothesis.
    Menendez JA; Colomer R; Lupu R
    Med Hypotheses; 2005; 64(2):337-41. PubMed ID: 15607568
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Enoyl-ACP reductase (FabI) of Haemophilus influenzae: steady-state kinetic mechanism and inhibition by triclosan and hexachlorophene.
    Marcinkeviciene J; Jiang W; Kopcho LM; Locke G; Luo Y; Copeland RA
    Arch Biochem Biophys; 2001 Jun; 390(1):101-8. PubMed ID: 11368521
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Structural basis and mechanism of enoyl reductase inhibition by triclosan.
    Stewart MJ; Parikh S; Xiao G; Tonge PJ; Kisker C
    J Mol Biol; 1999 Jul; 290(4):859-65. PubMed ID: 10398587
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Inhibition of fatty acid synthesis induces programmed cell death in human breast cancer cells.
    Pizer ES; Jackisch C; Wood FD; Pasternack GR; Davidson NE; Kuhajda FP
    Cancer Res; 1996 Jun; 56(12):2745-7. PubMed ID: 8665507
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Structure-activity studies of the inhibition of FabI, the enoyl reductase from Escherichia coli, by triclosan: kinetic analysis of mutant FabIs.
    Sivaraman S; Zwahlen J; Bell AF; Hedstrom L; Tonge PJ
    Biochemistry; 2003 Apr; 42(15):4406-13. PubMed ID: 12693936
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Effects of triclosan on growth, viability and fatty acid synthesis of the oyster protozoan parasite Perkinsus marinus.
    Lund ED; Soudant P; Chu FL; Harvey E; Bolton S; Flowers A
    Dis Aquat Organ; 2005 Nov; 67(3):217-24. PubMed ID: 16408837
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Paradigm shifts in malaria parasite biochemistry and anti-malarial chemotherapy.
    Surolia N; RamachandraRao SP; Surolia A
    Bioessays; 2002 Feb; 24(2):192-6. PubMed ID: 11835284
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.